,

2
.

NIDDK, National Diabetes Statistics 2007.

www.diabetes.niddk.nih.gov/dm/pubs/statistics

 (IFG):
- : 100-125mg/dl

(IGT):
- 2- OGTT: 140-199 mg/dl

(bA1c): 5.7-6.4% *
(DA, WHO)

* 2

 OGTT

,


(>140 mg/dl)
(IFG)

 HbA1c
..;

HBA1c, ,

Shingon , Dong XL
,
900 (Shingon),
OGTT, HBA1c
(, ,
BMI).

HBA1c
,

HBA1c - OGTT



2

.

(Exp Clin Endocrinol Diabetes 2010 Nov 19)


HbA1c,
,
,
,

,
HbA1c

( ),
.

.


.
2
,


( , ),
.

 (DECODE)
-2
- :
- IGT -2: X 5
- IFG -2: 4,7
- IFG + IGT -2: 12

* GT (- ) -2: 0.7%

CV
- IGT : X 1.7

- IFG : 1,2

-IGT: 7.9%

-2/

Diabetes Care, "Older Subjects With

Diabetes and Prediabetes Are Frequently
Unaware of Having Distal Sensorimotor
Polyneuropathy: The KORA F4 Study"
.Last Updated: May 22, 2013 DIABETES CARE

RESEARCH DESIGN AND METHODS

Glucose tolerance status was determined in 61- to 82year-old participants of the population-based KORA F4
Study (20062008) (n = 1,100).

DSPN ( )
154 (14%) , 140
.
23,9% (95% CI 12,6 38,8),


DSPN. , 10 11 (91%)
DSPN.

DSPN 22,0% (16,2 28,9)], 30 39 (77%) DSPN
.

, 18 25
(72%)
DSPN

CVD
CHD

Stroke
All causes

1.5

Hazard ratio

* *

*
* *

0.5
0
IFG

DM
(7.0)

IGT

DM
()

Known
DM

From DECODE Study Group. AIM 2001;161:397-405

IGT
Austrian study: 238 .

30

25
20

IFG
IGT
.
.. 2

15
10

5
0
Matz K et al.: Diabetes Care 2006; 29: 792-7.


&
(Prediabetes Signals CAD Risk)
By Ed Susman, Contributing Writer, MedPage Today
Published: May 03, 2013 AACE

In the study, about 36% of patients with impaired fasting glucose

had coronary artery disease compared with 42% of patients with

diabetes and 21% of patients with normal blood glucose said Harith
Al-Shuwaykh, MD, a resident in internal medicine at Crittenton
Hospital Medical Center, Wayne State University, Detroit.

Those findings, which were based on a review of 86 patients who

underwent elective percutaneous coronary intervention, were
presented at the annual meeting of the American Association of
Clinical Endocrinologists.

Likewise 37% of patients with impaired fasting glucose had

hyperlipidemia compared with 38% of patients with diabetes and

24% of patients with normal blood glucose.

Eriksson et al. Prevention of Type 2 DM by

diet and physical exercise:
The 6-y Malm study.
Diabetologia 1991, 34:891-898
41 2, 161 IGT

2: 28% ., 26% IGT, 46% 2

IGT: 69% ., 21% IGT, 10% 2

-
10
2


(RR0.69, 95%CI 0.58-0.83)

Jeon CY . Diabetes Care 2008;30:44

DPS, DPP, DPPO *

5-10%
30/

-2 58%
CVD


N = 3.234

N = 266

N = 3.304

N = 9.297

N = 3.234

N = 1.429

N = 9.193

IGT 2

DPP study
TRIPOD study

- 55 %

XENTROS study

- 34 %

DPP study

LIFE study

- 31 %

- 25 %

- 25 %

Troglitazone

Orlistat

- 37 %

HOPE study

STOP-NIDMM study

Lifestyle

- 58 %

Ramipril
Metformin

Acarbose
Losartan


-2

(DPP)*:

31%

(SP-NIDDM):

25%

(XENDOS):

37%

(DREAM):

62%

(CT-NOW) *

72%

(NAVIGATOR):

14%

(NAVIGATOR)

* , *

Fitness, Fatness, and Survival in Adults With

Prediabetes

Paul A. McAuley, Enrique G. Artero, Xuemei Sui, Carl J.

Lavie, M. Joao Almeida, Steven N. Blair
Disclosures Diabetes Care. 2014;37(2):529-536.

(CRF)
(
).

CRF ,
(CVD) 17.044
(89% ) (IFD,
100 mg / dL <126 mg / dL),
, CVD, .


CRF

.

BIOTIKO E

2 , .
,
( USDA )
.
,
( NHANES ) ,
2.400
2 .



35 .
Database, at-Home .

,
,
.
.
,

.

.

 2

$ 1,50

10 ,
20 (mg / dL), 13%

, 162 mg / dL.

14

9 mg / dL
, 6% .

ADA 2013-14

, 7%
& 150

/ ( )

As is the case for all children, children with diabetes or prediabetes should be
encouraged to engage in at least 60 min of physical activity each day. (B)

ADA 2013

:
-

- < 60
- 35

metformin
. (A)

 ADA 2014


In those identified with prediabetes, identify and, if appropriate, treat other
cardiovascular disease (CVD) risk factors. (B)


1.

5-10%
, 30
( 180 min
)
2.

( LDL < 100mg/dl, HDL >4OMG/Dl

>50mg/dl, < 200mg/dl,
<135mm/Hg <80mm/Hg).

1
57 , , 32,5,
1, 54 , 89
2 ,
115mg/dl , chol 219mg/dl,
trg189mg/dl, LDL165mg/dl, HDl35mg/dl,
140/90mm/hg, HBa1c6,5%. ,
. :

;

,



6

0:110mg/dl,
120: 165mg/dl

(-)


-


59 ,
2 28, 2

3 128
119mg/dl . CHOL 251mg/l, TRG
350mg/dl, HDL 29mg/dl, LDL 104mg/dl,
SGOT/SGPT 30/7Omg/dl, GT124mg/dl,
HBa1c 5,9%. :

2
;

,
GLP1
,
- 6

0:120mg/dl,
120: 196mg/dl

GLP1
,
6

 !

,

Perreault L, Pan Q, Mather KJ, Watson KE,

Hamman RF, Kahn SE; Diabetes Prevention
Program Research Group, Lancet. 2012;379:22432251

 A total of 1990 DPPOS participants were studied

(736 from the DPP lifestyle intervention group,

647 from the metformin group, and 607 from the
placebo group). Participants who achieved normal
glucose regulation at least once during the DPP had
a 56% reduced risk for progression to diabetes
during the DPPOS. Furthermore, diabetes risk was
reduced 47% in DPPOS if normal glucose regulation
was attained only once, but 61% if it was reached
twice and 67% if it was reached 3 times. Previous
randomization group in the DPP did not affect risk
reduction in the DPPOS in participants who
attained normal glucose regulation.

,

, .
Diabetes

(DPPOS)


,

.