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Inflammation

Wielding the Double Edged Sword in your Apitherapy Practice
25th Annual CM American Apitherapy Society
© Bradford

S. Weeks, M.D. Founder, AAS

Medical Director, Alternative Health Advocates, LLC
www.alternativehealthadvocates.com and www.weeksmd.com and www.weeksclinic.com

Contact: brad@alternativehealthadvocates.com TEL 360-341-2303 FAX 360-341-2313 skype bradfordweeks
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….THE APITHERAPY CONFERENCE IS SOLD OUT!

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GOALS for this Presentation
1) Clarify the dual roles of inflammation 2) Clarify the anti-inflammatory effect of apitherapy 3) Share protocols to enhance healing effects of inflammation 4) Inflame you all with enthusiasm and awe regarding the honey bee and apitherapy!

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“All symptoms are healing gestures”
• Photo of me and Sam Hah

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Benefits of Inflammation
• Dilution of toxins reducing further damage they might do if not diluted • Increases pain thereby limiting motion and preventing further injury • Increased vascular permeability allows arrival of healing cytokines and antibodies at the injury site • Leakage allows blister protection and fibrinogen to coagulate blood • While blood cells create ―noble pus‖(Honey, Mud, Maggots… Root-Bernstein) • IL-6 and IL-8 recruit benign stem cells fro the mesenchyme to come and repair tissue
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Anti-Inflammatory Agents
a) cortisone drugs such as prednisone b) non-steroidal anti-inflammatory drugs (NSAIDs) have been shone to delay the rate of muscle fiber regeneration c) applying ice or cold packs
• - See more at: http://naturalpharmacist.net/index.php?categories=Infla mmation#sthash.jYGbFC8z.dpuf

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Natural Anti-Inflammatory Agents
• LIFESTYLE: Increase Oxygen (hypoxemia stimulates CSCs) via: exercise, deep restorative sleep, yoga, meditation, lowering stress; • DIET: Curcumin, Sulforphane, Vitamin D3, Carotenoids, Propolis, Fermented Soy and organic raw non-GMO seeds: ―Eat the Seed‖

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Side-Effects of Anti-Inflammatory Agents
Immune suppression Retarding healing responses of muscle & tissue Gastro-intestinal bleeding Steroid Psychosis Death

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1918 Spanish Influenza Deaths
―Most intriguing and tragic is the new analysis by medical historians that the vast majority of poor souls who died during the 1918 Spanish influenza died not of infection but of over-dosage of a new drug just released on the market: aspirin. Today, all doctors know the lethality of high-dose aspirin, but when first released, the naïve assumption that ―if some is good, more is better‖ resulted in trusting patients being overdosed with aspiring and bleeding to death. Iatrogenic (i.e. doctor caused) death blamed on an influenza virus.‖
BSW http://weeksmd.com/2014/03/quench-inflammation-driving-cancer/
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Aspirin: What killed everyone in 1918 -1919
Salicylates and Pandemic Influenza Mortality, 1918–1919 Pharmacology, Pathology, and Historic Evidence
Karen M. Starko

The high case-fatality rate—especially among young adults—during the 1918–1919 influenza pandemic is incompletely understood. Although late deaths showed bacterial pneumonia, early deaths exhibited extremely ―wet,‖ sometimes hemorrhagic lungs. The hypothesis presented herein is that

aspirin contributed to the

because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary edema in 33% and 3% of
incidence and severity of viral pathology, bacterial infection, and death, recipients, respectively.
SOURCE http://weeksmd.com/2014/02/safer-anti-inflammatory-agent/ Alternative Health Advocates © 2014 www.alternativehealthadvocates.com

Pro-Inflammatory Agents
• • • • • • Bee venom Prolotherapy Heat Trauma Overdoing it Junk Food (white sugar, high fructose corn syrup, daily, wheat, soda pop)
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Too much of a good thing
• Mae West Photo

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BVT as Anti-Inflammatory Agent for various Illnesses
• Photo of bee

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An Overview of Bee Venom Acupuncture in the Treatment of Arthritis
• Bee venom acupuncture (BVA), as a kind of herbal acupuncture, exerts not only pharmacological actions from the bioactive compounds isolated from bee venom but also a mechanical function from acupuncture stimulation. BVA is growing in popularity, especially in Korea, and is used primarily for pain relief in many kinds of diseases. • The anti-inflammation and analgesic actions of BVA were proved in various kinds of animal arthritic models. • Two randomized controlled trials and three uncontrolled clinical trials showed that BVA was effective in the treatment of arthritis. It is highly likely that the effectiveness of BVA for arthritis is a promising area of future research.
• Evid Based Complement Alternat Med. 2005 Mar;2(1):79-84. Lee JD, Park HJ, Chae Y, Lim S.

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ALS - LOU GEHRIG’S DISEASE
Amyotrophic lateral sclerosis (ALS) is a paralyzing disorder characterized by the progressive degeneration and death of motor neurons and occurs both as a sporadic and familial disease. Mutant SOD1 (mtSOD1) in motor neurons induces vulnerability to the disease through protein misfolding, mitochondrial dysfunction, oxidative damage, cytoskeletal abnormalities, defective axonal transport- and growth factor signaling, excitotoxicity, and

neuro-inflammation.

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Anti-Inflammation: BVT and ALS
ABSTRACT • Bee venom has been used in the practice of Oriental medicine and evidence from the literature indicates that BV plays an antiinflammatory or anti-nociceptive role against inflammatory reactions associated with arthritis and other inflammatory diseases.

Conclusion • From these findings, our research suggests BV could be a potential therapeutic agent for anti-neuroinflammatory effects in an animal model of ALS.
Title: Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models Yang et al. Journal of Neuroinflammation 2010, 7:69 http://www.jneuroinflammation.com/content/7/1/69 Alternative Health Advocates © 2014 www.alternativehealthadvocates.com

Melittin and ALS – Anti-Inflammation
Melittin is a 26 amino acid protein and is one of the components of bee venom which is used in traditional Chinese medicine to inhibit of cancer cell proliferation and is known to have anti-inflammatory and antiarthritic effects. The purpose of the present study was to determine if melittin could suppress motor neuron loss and protein misfolding in the hSOD1G93A mouse, which is commonly used as a model for inherited ALS. The present work demonstrates that melittin reduces neuroinflammatory events
Title: Melittin restores proteasome function in an animal model of ALS AU Eun Jin Yang1*,Yang et al. Journal of Neuroinflammation 2011, 8:69 http://www.jneuroinflammation.com/content/8/1/69 Alternative Health Advocates © 2014 www.alternativehealthadvocates.com

BVT and Heart
Despite its well documented anti-inflammatory property, there are no reports regarding the influence of Bee Venom on the expression of cellular adhesion molecules in the vascular endothelium…anti-inflammatory process induced by BV…. The BV group had decreased levels of total cholesterol (TC) and triglyceride (TG) in their serum, compared to the LPS/fat group….The amount of cytokines reduced consistently in the BV treatment groups compared with those in LPS/fat group. BV significantly reduced the amount of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM1), transforming growth factor-β1 (TGF-β1) and fibronectin in the aorta, compared with the LPS/fat group (p < 0.05). A similar pattern was also observed in the heart. In conclusion, BV has anti-atherogenic properties via its lipid-lowering and anti-inflammatory mechanisms.
Bee venom reduces atherosclerotic lesion formation via anti-inflammatory mechanism. Lee WR et al Am J Chin Med. 2010;38(6):1077-92.

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BVT and Heart Health
OBJECIVE: To elucidate the possible effects of bee venom (BV) on cardiac electrophysiological properties in vivo, the inotropic and chronotropic properties of the isolated hearts in vitro, and the cardiac responsiveness to progressive adrenergic stimulation by isoproterenol.

CONCLUSION: The BV enhanced the cardiac inotropic reserve to beta-receptor agonists. Meanwhile, BV protected the heart against calcium overloadinduced injury.
Cardiac effects of bee venom in rats. Saleh NK1, et al Saudi Med J. 2011 Jun;32(6):563-70.

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BVT and Brain Inflammation
Bee venom (BV), which is extracted from honeybees, is used in traditional Korean medical therapy. Several groups have demonstrated the antiinflammatory effects of BV in osteoarthritis both in vivo and in vitro. Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS). Changes in glutamate release and uptake due to alterations in the activity of glutamate transporters have been reported in many neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. …. Furthermore, BV significantly inhibited the cellular toxicity of glutamate, and pretreatment with BV altered MAP kinase activation (e.g., JNK, ERK, and p38) following exposure to glutamate. These findings suggest that treatment with BV may be helpful in reducing glutamatergic cell toxicity in neurodegenerative diseases.
Effects of bee venom on glutamate-induced toxicity in neuronal and glial cells. Lee SM et al Evid Based Complement Alternat Med. 2012;2012:368196. doi: 10.1155/2012/368196. Epub 2011 Aug 28.

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BVT and Pancreas Inflammation
The major compound of bee venom, melittin, has been used as an anti-inflammatory reagent for decades. However, the potential of melittin to ameliorate acute pancreatitis (AP) is unknown. Our aim was to investigate the effect of melittin on cerulein-induced AP. Pre- and post-treatment with melittin inhibited histological changes in the pancreas and lungs during cerulein-induced AP. …In accordance with the results of in vivo experiments, melittin reduced cerulein-induced cell death, and production of inflammatory cytokines. In conclusion, our results suggest that melittin attenuated AP and AP-associated lung injury through the inhibition of JNK activation.
Melittin inhibits cerulein-induced acute pancreatitis via inhibition of the JNK pathway. Yun SW1, et al Int Immunopharmacol. 2011 Dec;11(12):2062-72. doi: 10.1016/j.intimp.2011.08.020. Epub 2011 Sep 20.

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BVT and Liver Inflammation
Acute hepatic failure remains an extremely poor prognosis and still results in high mortality. Therefore, better treatment is urgently needed. Melittin, a major component of bee venom, is known to inhibit inflammatory reactions induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF)-α in various cell types. … treatment of melittin attenuated the increase of inflammatory cytokines…. Melittin significantly inhibited the expression of caspase and bax protein levels as well as cytochrome c release in vivo. In addition, melittin prevented the activation of the transcription factor nuclear factor-kappa B (NF-κB) induced by GalN/LPS. These results clearly indicate that melittin provided protection against GalN/LPS-induced acute hepatic failure through the inhibition of inflammatory cytokines and apoptosis.
Protective effect of melittin on inflammation and apoptosis in acute liver failure. Park JH1, et al Apoptosis. 2012 Jan;17(1):61-9. doi: 10.1007/s10495-011-0659-0.

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BVT and Liver Fibrosis
Liver fibrosis represents a process of healing and scarring in response to chronic liver injury. Following injury, an acute inflammation response takes place resulting in moderate cell necrosis and extracellular matrix damage. Melittin, the major bioactive component in the venom of honey bee Apis mellifera, is a 26-residue amphipathic peptide with well-known cytolytic, antimicrobial and proinflammatory properties…. Melittin suppresses the expression of proinflammatory cytokines through the nuclear factor (NF)-κB signaling pathway…. Melittin prevents TAA-induced liver fibrosis by inhibiting liver inflammation and fibrosis, the mechanism of which is the interruption of the NF-κB signaling pathway. These results suggest that melittin could be an effective agent for preventing liver fibrosis.
Melittin attenuates liver injury in thioacetamide-treated mice through modulating inflammation and fibrogenesis. Park JH1, et al Exp Biol Med (Maywood). 2011 Nov;236(11):1306-13. doi: 10.1258/ebm.2011.011127. Epub 2011 Oct 3.
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BVT and Prostate Cancer
Bee venom has been used as a traditional medicine to treat arthritis, rheumatism, back pain, cancerous tumors, and skin diseases. However, the effects of bee venom on the prostate cancer and their action mechanisms have not been reported yet. Bee venom (1-10 µg/ml) and melittin (0.5-2.5 µg/ml) inhibited cancer cell growth through induction of apoptotic cell death in LNCaP, DU145, and PC-3 human prostate cancer cells. These effects were mediated by the suppression of constitutively activated NF-κB. …Therefore, these results indicated that bee venom and melittin could inhibit prostate cancer in in vitro and in vivo, and these effects may be related to NF-κB/caspase signal mediated induction of apoptotic cell death.
Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB. Park MH et al Prostate. 2011 Jun 1;71(8):801-12. doi: 10.1002/pros.21296. Epub 2010 Nov 17 Alternative Health Advocates © 2014 www.alternativehealthadvocates.com

Anti-Inflammatory Agents in Corrective Cancer Care

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The Revolution in Oncology
“Chemotherapy and radiation make cancer worse.”
Distinguished Professor Max Wicha, M.D. Director, U. Michigan Comprehensive Cancer Center “When discussing potential targets for the treatment of cancer today, the conversation will generally lean towards targeted therapy of cancer stem cells (CSCs).” Professor Max Diehn, M.D. Stanford U.
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THE FINAL COMMON TARGET PATHWAY is….

INFLAMMATION !
Thymoquinone inhibits the IL-6-induced proliferation of MM cells AND suppresses STAT3 phosphorylation and the expression of its downstream signaling effectors Bcl-2 and Bcl-XL. By inhibiting STAT3, TQ also had a strong effect on many other bad guys in myeloma, such as cyclin D1, the Bcl family, survivin, Mcl-1 and VEGF. CX CL 12 is a powerful cytokine which

acute or chronic inflammatory process and resides in bone marrow – it feels
activates white blood cells during bones instruction and angiogenesis.

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Evolving medical knowledge regarding…

INFLAMMATION
1. 2. 3. 4. 5. Inflammation is not just related to painful joints. Inflammation is the major factor driving the aging process. Inflammation underlies all major degenerative diseases. Cardiovascular inflammation leads to calcification / blockage. Cancer metastasis is an inflammatory process.

6. Cancer recruitment of stem cells is an inflammatory process. 7. Schizophrenia and psychosis is an inflammatory process.

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―These findings begin to create a vision of rational adjunctive antiinflammatory therapy to “quench the fire” in schizophrenia. Inflammation may play a role in other psychiatric disorders, such as 1) bipolar disorder, 2) schizophrenia, 3) autism and 4) post-traumatic stress disorder. SOURCE Michael Berk http://www.biomedcentral.com/1741-7015/11/200

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“EAT THE SEEDS!”

What is a seed?
• Treasure chest (20 fold more nutrients than the plant) • Embryo, ―time capsule‖
• Protected from destruction by bitter shells

• Shell = condensation of polymannose (nutrient dense)
• Seed is on a mission to reproduce
• Persistent and Resilient: The Seed Finds a Way.
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“The seed husk has condensed polymannose (glucose polymers) which not only enhances absorption but also amplifies CD-14 which triggers adult stem cells development. This is similar to sending in the architect, the general contractor and the skilled craftsmen.” (BSW in press)

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Genetics 101
RNA - sends messages to DNA instructing the cells to optimize function and adapt to stressors. Q: Where is RNA concentrated in plants? A: In the seed.

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HAIR COLOR: age 90 after 3 months on Seed Product

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Mother Nature DOES put all her eggs in one basket…. … it’s called a ―seed‖!

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Choose your seeds wisely.
HINT….

―Black cumin seed oil is 281x more potent an antiinflammatory agent compared to aspirin.‖
Dr. Liangli Yu Ph.D. U Maryland, Nutrition & Food Science

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BLACK CUMIN SEED
“For centuries, the black seed (Nigella sativa) herb and oil have been used in Asia, Middle East and Africa to promote health and fight disease.
Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer
cells via a

p53-dependent

mechanism. Gali-Muhtasib, H; et al Source: International Journal of Oncology 2004

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Thymoquinone: potential cure for inflammatory disorders and cancer.
Source: Biochem Pharmacol. 2012 Feb 15 ;83(4):443-51. Epub 2011 Oct 10. PMID: 22005518 Abstract Author(s):Chern Chiuh Woo

The anti-tumor effects of thymoquinone have also been investigated in tumor xenograft mice models for colon, prostate, pancreatic and lung cancer. The combination of thymoquinone and conventional chemotherapeutic drugs could produce greater therapeutic effect as well as of the latter.

reduce the toxicity

In this review, we summarize the anti-oxidant/anti-inflammatory and anticancer effects of thymoquinone with a focus on its molecular targets, and its possible role in the treatment of inflammatory diseases and cancer.
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About Black Raspberry Seed
1) “We found that non-toxic levels of black raspberry significantly inhibited the growth of human cervical cancer cells.” 2) “Black raspberries and their bioactive components represent promising candidates for future phytochemical-based mechanistic pathway-targeted cancer prevention strategies.” 3) “Black raspberries have been shown to inhibit multiple stages of oral, esophageal, and colon cancer.” 4) Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. 5) “Black raspberry extracts (RSE) have been shown to inhibit breast cancer cell growth and stimulate apoptosis.” 6) “The ability of topical BRE to reduce acute UVB-induced

inflammation and to decrease tumor development in a long-term model
provides compelling evidence to explore the clinical efficacy of BRE in the prevention of human skin cancers.”
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Seeds as Nourishing Food
Organic, raw, non-GMO seed-based Nutritional supplements now offer the equivalent of……

8-10 serving of organic FRUIT
2-3 servings of organic, non-GMO cold-pressed HEALTHY OILS

8-10 servings of organic VEGETABLES
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Analysis Oxygen Radical Absorptive Capacity (ORAC)
Antioxidant capacity is a central feature of phyto-compounds, and the kind of compound diversity represented by Soul leads to broad-spectrum antioxidant protection. Antioxidants help protect our bodies against the damaging effects of free radicals. While a necessary part of human metabolism, radicals can become harmful if there are too many of them. Total ORACFN provides a measure of the total antioxidant power of a food/nutrition product against the five predominant reactive species.

Seed Product ORAC VALUE = 4,402 per ounce (orange juice 233 per ounce)
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"I have great faith in a seed. Convince me that you have a seed there, and I am prepared to expect wonders."

Henry David Thoreau The Succession of Forest Trees

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Summary: BVT is a double edged Sword
1) We need both inflammation and anti-inflammation

1) Excessive and chronic of either polarity is not healthy
1) The balance of inflammation depends upon the health and nutritional inventory of the patient. 4) BVT is like “the jockey”; eating seeds is like “the trainer”; 5) Prepare the patient BEFORE starting BVT - No alcohol and Rehydrate - Clean up the diet (add honey propolis pollen) - Supplement: Vitamin C, Vitamin B5, SOUL, Clear TRS - Eat the seeds (organic, raw, non-GMO)
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