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Post-streptococcal infection

(group A, beta-hemolytc)

Release of material from


the organism into the circulation
(antigen)

Formation of antibody

Antigen-antibody complex
trapped in the glomeruli

Inflammatory response
Proliferation of endothelial
cells

Increased permeability EDEMA


of basement membrane

Occlusion of the capillaries of


glomeruli
Vasospasm of afferent arterioles

Decreased GFR

Retention of water and sodium


Hypervolemia HYPERTENSION
Circulatory congestion
protenuria

Hypoalbuminemia

Decreased COP

Fluid loss to the interstitial space

Edema

back
oliguria

retention of water and sodium

hypervolemia

hypertension

bac
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