Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph.

D
Department of Pharmaceutics
KLE University College of Pharmacy
BELGAUM-590010, Karnataka, India

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

1

Nanotechnology

Nanotechnology breakthrough research
Neutraceutical and Cosmetic Industry.

Nanotechnology, a field of science and
technology that aims to control matter at the
atomic and molecular level.

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

in

2

Neutraceuticals

Neutraceutical, a term combining the words
"nutrition" and "pharmaceutical", is a food or
food product that provides health and medical
benefits, including the prevention and treatment
of disease.

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

3

capsules of soft-gels. 4 . Ranchi. 14/12/2011 Birla Institute of Technology. Nutraceuticals are substances that are extracted from foods and are used either to fortify other food products in order to enhance their nutritional properties as dietary supplements in the form of pills. Mesra.Nutraceuticals and Pharmaceuticals   Nutraceuticals and pharmaceuticals are related in that both are types of compound that demonstrate bioactive properties.

5 . Mesra.Nutraceuticals 14/12/2011 Birla Institute of Technology. Ranchi.

Ranchi. Mesra.  Nutraceuticals are the intersection of nutrition and pharmaceutical and is an umbrella term that can also include functional foods and dietary supplements.  Eg. Omega-3 fatty acids that are both biocompatible and bioavailable. 6 .Nutraceuticals  Nutraceuticals are food extracts that have been demonstrated to produce a physiological benefit or provide some protection against chronic disease. 14/12/2011 Birla Institute of Technology.

Nutraceuticals Market 14/12/2011 Birla Institute of Technology. 7 . Ranchi. Mesra.

 Quantitative particle size. but many of the same analytical studies are conducted. formulation stability. solubility. 8 .Nano-Particle  Nutraceutical compounds do not yet fall under the same regulatory guidelines and control known to the pharmaceutical industry. 14/12/2011 Birla Institute of Technology. Ranchi. Mesra. and quality control. particle shape. and zeta potential analysis provides information that has either a direct effect or correlation to issues such as bioavailability.

9 . Ranchi.Particle Characterization 14/12/2011 Birla Institute of Technology. Mesra.

10 . Ranchi. Mesra.Particle Characterization 14/12/2011 Birla Institute of Technology.

Nano-Techniques  Nutraceutical researchers working to improve the bioavailability.  Measuring particle size in the nanometer  The SZ-100 dynamic light scattering nanoparticle size analyzer provides size information for nano scale suspensions and emulsions through a simple. Ranchi. and stability of various formulations measure particle size. 11 . particle shape. biocompatibility. Mesra. 14/12/2011 Birla Institute of Technology. and zeta potential. robust user interface.

12 .Neutraceuticals         Essential fatty acids such as omega-3 oils Probiotics Prebiotics Plant stanols and sterols Botanicals Superfruit extracts and antioxidants Carotenoid antioxidants Soy protein isoflavones 14/12/2011 Birla Institute of Technology. Mesra. Ranchi.

Ranchi. it can sometime prove difficult to formulate with other ingredients  Eg. and marine plankton and fatty fish. 13 .Essential fatty acids such as omega-3 oils  Omega-3 fats are found in flaxseed oil.  The main sources of omega-6 fats are vegetable oils such as corn oil and soy oil that contain a high proportion of linoleic acid. walnut oil. Mesra.  The dense composition of the oil. Nanoemulsion 14/12/2011 Birla Institute of Technology.

Ranchi.  When you eat probiotics.  Eg.  Common strains include Lactobacillis Bifidobacterium families of bacteria. Nanoliposomes and Nanoniosomes 14/12/2011 Birla Institute of Technology.Probiotics  Probiotics are beneficial bacteria that can be found in various foods. you will add these healthy bacteria to your intestinal tract. and 14 . Mesra.

 Prebiotics keep beneficial bacteria healthy. Nanoencapsulation 14/12/2011 Birla Institute of Technology. Mesra. 15 . Ranchi.Prebiotics  Prebiotics are non-digestible foods that make their way through our digestive system and help good bacteria grow and flourish.  Eg.

seeds. nuts.Plant stanols and sterols  Plant sterols and stanols are naturally occurring substances found in plants. 16 . Enhance aqueous solubility 14/12/2011 Birla Institute of Technology.  They are present in small quantities in many fruits.  Eg. Ranchi. cereals and legumes. Mesra. vegetables. vegetable oils.

17 . Ranchi. live plants & seeds  All plant derived substances which occur in nature 14/12/2011 Birla Institute of Technology.Botanicals  Range of substances which is covered by ‘Botanicals’. Mesra.  Extracts from non-gmo.

Nanosuspension. Capros® 14/12/2011 Birla Institute of Technology. oranges. blackcurrants. Ranchi. Mesra.Superfruit extracts and antioxidants  Fruit which combines exceptional nutrient richness and antioxidant quality with appealing taste that can stimulate and retain loyalty for consumer products. 18 . strawberries. tomatoes.  Eg. blackberries are not commonly mentioned as superfruits.  Some popular fruits like Apples.

Ranchi.  Eye Formula combines distinctive flavonoids. and antioxidants known to nourish and protect the delicate cellular tissue of eyes. naturally 14/12/2011 Birla Institute of Technology. some bacteria. and some types of fungus. 19 . Mesra. carotenoids.Carotenoid antioxidants  Carotenoids are tetraterpenoid organic pigments that are naturally occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae.

20 . Mesra. or topical administration. parenteral.Soy protein isoflavones  Soy protein and isoflavones (phytoestrogens) have gained considerable attention for their potential role in improving risk factors for cardiovascular disease. Ranchi.  Soy protien isoflavones for enteral. 14/12/2011 Birla Institute of Technology.

21 . 14/12/2011 Birla Institute of Technology. lipstick etc.  Some examples of cosmetic products consisting of or including particulates include facial powders. Mesra. Ranchi.Cosmetic  Many cosmetic products include particulate material or emulsions. moisturizers.

Facial Powders

Face powders may include talc, kaolin, iron oxide, zinc
oxide, titanium dioxide.

In addition to appearance enhancement, face powders
can also provide sunscreen protection with the inclusion
of strong light scattering components such as zinc
oxide.

The particle size distribution of these components
effects appearance, stability, and sunscreen protection.

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

22

Facial Powders

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

23

Moisturizers

Moisturizers are applied to the skin to improve hydration,
protect from drying, and improve appearances.

Most moisturizers are oil in water emulsions with
additives to improve stability or provide additional
benefits such as sun screening properties.

Formulating oil in water emulsions often requires
knowledge of both the size distribution of the dispersed
phase (oil) and the charge on the surface of the droplets
(the zeta potential).

14/12/2011

Birla Institute of Technology,
Mesra, Ranchi.

24

Mesra. 25 . Ranchi.Nanoemulsion 14/12/2011 Birla Institute of Technology.

Smaller particles create satin and silky effects while larger particle sizes create high luster effects such as sparkle. 14/12/2011 Birla Institute of Technology. Pearlescent pigments also add a shine to the appearance of the lipstick. Many pigments used in lipstick are particulate including effect pigments that add silk or pearlescent attributes. Mesra. Ranchi. 26 .Lipstick     The selection of pigments used for lipstick plays an important role in the final appearance.

27 . Mesra. Ranchi.Lipstick 14/12/2011 Birla Institute of Technology.

gel or cream February 9.Patents for Nanotechnolog in Cosmetics Company Application Title Key Language/Abstract (relevant claim in bold Date of Filed Published Application/ Patent Number ColgatePalmolive Deodorant with small particle zinc oxide This invention comprises a one phase cosmetic composition which can be made as a stick. 2005 2005220728 14/12/2011 Birla Institute of Technology. 28 . Mesra. Ranchi. 2001 6358499 L’Oreal Cosmetic composition comprising a polyglycerolated silicone elastomer Nanoparticles are between 5 nm and 600 nm in size March 22.

Ranchi.Nanotechnology Based Cosmetic Product  Moisturisers  Hair care products  Make up and suncreen 14/12/2011 Birla Institute of Technology. 29 . Mesra.

30 . Use of nanotechnology for delivery 14/12/2011 Birla Institute of Technology. Ranchi. Mesra.Main Uses of Nanotechnology 1. Use of nanoparticles as UV filters 2.

31 . Ranchi.Use of nanoparticles as UV filters  Titanium dioxide (Tio2) and zinc oxide (Zno) are the main compounds used in these applications.  Organic alternative to these have also been developed 14/12/2011 Birla Institute of Technology. Mesra.

Ranchi. bioavailability. Mesra. 32 .Use of nanotechnology for delivery  Nanoliposomes and Nanoniosomes are used in the cosmetic industry as delivery vehicles.  Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been found to be better performers than liposomes  NLCs have been identified as a potential next generation cosmetic delivery agent that can provide enhanced skin hydration. stability of the agent and controlled occlusion 14/12/2011 Birla Institute of Technology.

Mesra. Ranchi.Nanotechnology R&D in Cosmetics            Vesicular Delivery Systems (Nanoliposome & Nanoniosome) Nanoemulsions Solid Lipid Nanoparticles Nanostructured Lipid Carriers Dendrimers & Hyperbranched polymers Nanocrystals & Nanopowder Nanoencapsulation and controlled release Cubosomes Nanotechnology for UV protection Nanomechanical and Nanotribological study of hair Fullerenes 14/12/2011 Birla Institute of Technology. 33 .

34 . Ranchi. Mesra.Vesicular Delivery Systems  Nanoliposomes  Nanoniosomes 14/12/2011 Birla Institute of Technology.

Nanoliposomes  Liposomes are vesicular structures with an aqueous core surrounded by a hydrophobic lipid bilayer. 35 . therefore minimising the potential for adverse effects. created by the extrusion of phospholipids. Mesra.  The first liposomal cosmetic product to appear on the market was the anti-ageing cream ‘Capture’ launched by Dior in 1986. 14/12/2011 Birla Institute of Technology. Ranchi.  Phospholipids are GRAS (generally recognised as safe) ingredients.

Nanoliposomes 14/12/2011 Birla Institute of Technology. Ranchi. Mesra. 36 .

Ranchi.  The first product ‘Niosome’ was introduced in 1987 by L’Oréal company.Nanoniosomes  Niosomes are non-ionic surfactant based vesicles that have a similar structure to that of phospholipid vesicles like liposomes. 37 . 14/12/2011 Birla Institute of Technology. Mesra.   They are formed by the self-assembly of non-ionic surfactants in aqueous media.  They can be used to encapsulate aqueous solutes and act as drug and cosmetic carriers.

Mesra.Nanoniosomes 14/12/2011 Birla Institute of Technology. Ranchi. 38 .

Nanoemulsions  Nanoemulsions are dispersions of nanoscale droplets of one liquid within another.g. water-like fluids or gels.  L’Oreal own several patents on nanoemulsion based technologies. 39 .  Several companies supply ready to use emulsifiers for creating stable nanoemulsions for cosmetic applications. Mesra.  These emulsions are metastable systems whose structure can be manipulated based on the method of preparation to give different types of product e. Ranchi. 14/12/2011 Birla Institute of Technology.

40 . Ranchi.Nanoemulsion 14/12/2011 Birla Institute of Technology. Mesra.

41 . Mesra.  Their production is a relatively simple process where the liquid lipid (oil) in a nanoemulsion is exchanged by solid lipids. 14/12/2011 Birla Institute of Technology.  They are oily droplets of lipids which are solid at body temperature and stabilised by surfactants.Solid Lipid Nanoparticles  Solid lipid nanoparticles (SLNs) are nanometre sized particles with a solid lipid matrix.  This process does not require organic solvents. Ranchi.

Solid Lipid Nanoparticles 14/12/2011 Birla Institute of Technology. 42 . Ranchi. Mesra.

 Compared to SLNs.  The high loading capacity and long term stability offered by the NLCs make them superior to SLNs in many cosmetic applications.Nanostructured Lipid Carriers  Lipid particles have been developed by mixing solid lipids with liquid lipids (Nanostructured Lipid CarriersNLCs). 43 . Ranchi. NLCs have a distorted structure which makes the matrix structure imperfect and creates spaces to accommodate active compounds. Mesra. 14/12/2011 Birla Institute of Technology.

Ranchi. 44 .Nanostructured Lipid Carriers 14/12/2011 Birla Institute of Technology. Mesra.

monodisperse. Mesra. micellar nanostructures. with an architecture like a tree branching out from a central point.  Dendrimers are unimolecular. Ranchi.Dendrimers  Dendrimers considered for use in the cosmetic industry. with a welldefined. 14/12/2011 Birla Institute of Technology. 45 . regularly branched symmetrical structure and a high density of functional end groups at their periphery.  They are prepared in a step-wise fashion. around 20 nm in size.

Dendrimers 14/12/2011 Birla Institute of Technology. Mesra. Ranchi. 46 .

Hyperbranched Polymers  Hyperbranched polymers are effectively disorganised. 47 . 14/12/2011 Birla Institute of Technology.  The large number of external groups suitable for multifunctionalisation which is a requirement for its use as a cosmetic agent carrier. Ranchi. Mesra. making them much more cost-effective than dendrimers. unsymmetrical dendrimers that are prepared in a single synthetic polymerisation step.

Ranchi. Mesra. 48 .Hyperbranched Polymers 14/12/2011 Birla Institute of Technology.

  They are aggregates comprising several hundred to tens of thousands of atoms that combine into a "cluster". Mesra.  Typical sizes of these aggregates are between 10-400 nm and they exhibit physical and chemical properties somewhere between that of bulk solids and molecules. 14/12/2011 Birla Institute of Technology. 49 .Nanocrystals  Nanocrystals have been used in the cosmetic industry for the delivery of poorly soluble actives.  The crystals must be stabilised to prevent larger aggregates from forming. Ranchi.

Mesra.Nanocrystals 14/12/2011 Birla Institute of Technology. 50 . Ranchi.

Ranchi. 14/12/2011 Birla Institute of Technology.  Nanopowder have been of extreme interest in the Cosmetic field.Nanopowder  Nanopowder are solid particles that measure on the nanoscale. side effects are lessened due to better use of cosmetics.  Because of a combination of these. Mesra. 51 . usually comprised of three to five molecules together.  Smaller particles mean better absorption by the body therefore less drug is needed.

52 .Nanopowder 14/12/2011 Birla Institute of Technology. Ranchi. Mesra.

14/12/2011 Birla Institute of Technology.Nanoencapsulation and controlled release  Such nanosized particles which have a shell and an interior space that can be used to load drugs are called nanocapsules. Ranchi.  Polymers have been widely used to create nanocapsules which are then functionalised for various applications. Mesra.  Different types of nanocapsules are required depending on the nature of the material (hydrophobic or hydrophilic) to be incorporated. 53 .

Nanoencapsulation and controlled release 14/12/2011 Birla Institute of Technology. 54 . Mesra. Ranchi.

very viscous material that has a unique structure at the nanometer scale.Cubosomes  Cubosomes are nanostructured particles of bicontinuous cubic liquid crystalline phase. 14/12/2011 Birla Institute of Technology. 55 .  They are an attractive choice for cosmetic applications as well as for drug delivery.  Bicontinuous cubic liquid crystalline phase is an optically clear.  They have high heat stability and are capable of carrying hydrophilic and hydrophobic molecules. Mesra. Ranchi.

Cubosomes 14/12/2011 Birla Institute of Technology. 56 . Ranchi. Mesra.

Avon. Nivea and Unilever. The Body Shop. 14/12/2011 Birla Institute of Technology.  Products using nanoparticles of ZnO or TiO2 are transparent so have increased aesthetic appeal. are less smelly. L’Oréal. 57 . Mesra.  Many sunscreens and moisturisers available now use these nanoparticles.Nanotechnology for UV protection  Zinc oxide (ZnO) and titanium dioxide (TiO2) particles have been widely used for many years as UV filters in sunscreens. less greasy and more absorbable by the skin. including products from Boots. Ranchi.

58 .ZnO and TiO2 Nanoparticles 14/12/2011 Birla Institute of Technology. Ranchi. Mesra.

Asian and African hair) as these can respond differently to activities like shampooing.  Understanding the differences between hair types allows cosmetic companies to create products to suit individual hair types (e. ethnic differences between Caucasian. Mesra.g.Nanomechanical and Nanotribological study of hair  Nanotechnology has been used to study the mechanical characteristics of hair. styling or colouring. Ranchi. 14/12/2011 Birla Institute of Technology. 59 .   The hair care industry is also interested in the effect of water on the nanomechanical properties of hair.

ellipsoid. Ranchi. 60 . or tube. Mesra.  Cylindrical ones are called carbon nanotubes or buckytubes. 14/12/2011 Birla Institute of Technology.  Spherical fullerenes are also called buckyballs. in the form of a hollow sphere. and they resemble the balls used in association football.Fullerenes  A fullerene is any molecule composed entirely of carbon.

Mesra. 61 .Fullerenes 14/12/2011 Birla Institute of Technology. Ranchi.

62 .in 14/12/2011 Birla Institute of Technology. Ranchi. Mesra.Contact No: 00919742431000 E-mail: bknanjwade@yahoo.co.