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1

2 +5%
5 +10 -15%
15 +20 -40%

5
9%

15
16%
16%

15


HDL


HDL

LDL
.
LDL

HDL
. .


B-b

HDL
HDL

, , , ,
, , , ,
.


HDL-C


trans








LDL ~ 5%
~ 20%



HDL-C

> 500 mg/dl (

/ 3

> 3
( , , )

CPK > 5X .

(, , ,
, )

CK > 1000 mg/dl, >120 mg/dl

:
/

5-7/100


CK

1-10/1.000


CK>10 ULN

1-2/10.000


CK ( >10
ULN)
(
)

Pasternak RC et al. Circulation 2002;106:1024-8


Evans M, Rees A. Drug Saf 2002;25:649-63

>2


(PRIMO STUDY)

Cardiovascular Drugs Ther 2005; 19(6) 403-414.



1.

2. /
3.

1. -
2. CPK > 5X A
3. > 3
:
, ,
, , ,
.

LDL-C

10%-12%

LDL-C

3%-5%

LDL-C

5%

Policosanol and red yeast rice

LDL-C

20%-30%


CK

LDL-C
>400


+
,
, .




( )