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Arginine Cardio: Evidence-based reduction of blood pressure (1)

L-Arginine is the precursor of Nitric Oxide


L-Citrulline potentiates the bioavailability of L-arginine
Arginine Cardio is the L-Arginine supplement that has the highest L-citrulline
Content
Nitric Oxide causes vasodilation and thereby reduces blood pressure.

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Arginine Cardio: Evidence-based reduction of blood pressure (2)


L-Arginine is not being marketed by pharmaceutical industry
with a multi million dollar budget for promotion.
Clinical trials with L-arginine to lower blood pressure have been performed
by independent academic research institutions, with small research budgets.
Therefore, patient numbers in clinical trials with L-arginine
are comparatively small.
However, there is a recent meta-analysis summarizing clinical trials
with L-arginine.

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Arginine Cardio: Evidence-based reduction of blood pressure (3)

11 randomized, double-blind, placebo-controlled trials involving 387 participants


with oral L-arginine intervention ranging from 4 to 24 g/d

[] Compared with placebo, L-arginine intervention significantly lowered


systolic blood pressure by 5.39 mm Hg (95% CI 8.54 to 2.25, P = .001) and
diastolic BP by 2.66 mm Hg (95% CI 3.77 to 1.54, P = .001).

Dong et al.; American Heart Journal 2011


Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

L-Arginine better

Placebo better
Dong et al.; American Heart Journal 2011

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

L-Arginine better

Placebo better
Dong et al.; American Heart Journal 2011

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Dong et al.; American Heart Journal 2011


Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Arginine Cardio: Evidence-based reversal of atherosclerosis (1)


Nitric Oxide has been known to protect from atherosclerosis ever since
the Nobel Prize for Medicine was awarded for this finding in 1998.
L-Arginine is the precursor of Nitric Oxide.
Animal experiments have unequivocally proven in different models and in
various laboratories around the world that L-arginine can reverse atheroslcerosis.
Whilst no big, multinational studies could be performed with L-arginine due to
lack of funding from public sources, multiple studies have shown reversal of
endothelial dysfunction, the early clinical sign of atherosclerosis, by L-arginine.
We have a collection of case reports that show reversal of atherosclerotic plaque
in humans during a few months of L-arginine intake.
Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Study A: Prevention of Plaque Build-Up


Design:

Cholesterol + L-Arginine
Cholesterol
Control
0

weeks

Results:

A. carotis

60

Cholesterol

Carotid intimal plaque area


[% of total intima]

55
50
45
40
35
30
25
20
10
5
0

Cholesterol; treated with L-arginine

15

(0)
CONTROL

CHOLESTEROL

CHOL.
+ L-ARGININE

Bger et al., Atherosclerosis 1995; 117: 273 284


Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Study B: Stopping the Progression of Plaque Build-Up


Cholesterol + L-Arginine

Design:

Cholesterol

Cholesterol

Cholesterol + Lovastatin
Control

Control

Intimal plaque area


(carotid artery) [%]

Results:

10

16

weeks

50
40
30

Dietary L-arginine completely suppressed


the aggravation of intimal plaque formation
during the second part of the study
Lovastatin treatment significantly reduced
the progression of plaque formation but did
not completely block it.

-92%

20
10
0

16

weeks

Bger et al., Circulation 1997; 96: 1282-1290


Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Study C: Reversal of Pre-Existing Plaque


Design:

Cholesterol
Cholesterol

Cholesterol + L-Arginine
Cholesterol

Intimal plaque area


(carotid artery) [%]

Results:

10

18

23

weeks

75
60

This is the first demonstration that


restoration of NO activity can induce
regression of preexisting intimal lesions
and provides evidence that L-arginine therapy
may be of potential clinical benefit

45
30
15
0

10

14

18

23

weeks

Candipan et al., Arterioscler. Thromb. Vasc. Biol. 1996; 16: 44-50


Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013

Author: Dr. Rainer Bger

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Arginine Benefits LLC, 2013