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NEUROBLASTOMA
Introduction
Epidemiologi
Embryology,pathology and
genetics
Embryology:
Neural crest is the embryonic structure which
gives rise to the sympathetic nervous system
and also part of the facial skeleton, the
thymus,parathyroids,the
enteric
nervous
system and skin melanocytes.
Pathology:
Histologically: vary heterogenous and are
compose of two predominant cell types: thr
neuroblast/ganglion cell and the Schwann cell.
Genetics:
A genetics predisposition exists in families
Genetic studies: amplification of oncogens or
chromosomal and chromosomal losses.
Clinical presentation
Diagnostic criteria
International Neuroblastoma Staging
System (INSS) working party have been
clearly that diagnosis of neuroblastoma
by a tissue biopsy, with a histological
appearance of neuroblastoma or by the
presence of a non-haemopoietic tumor
in the bone marrow , together with
raised urinary cathecolamines. In the
bone marrow , neuroblastoma often has
the appearance of pseudorosettes.
Staging system
Stage 2a
Stage 2b
Stage 3
Stage 4
Stage 4s