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Herbal Antipyretic

Ayu Gayatri Sistiafi (1306447663)
Diana Christina (1306370902)
Getta Austin Mangiring (1306405364)
Nadia Tuada Afnan (1306413422)
Nadira Putri Pinasthika (1306370814)
Satria Pasthika (1306371041)

OUTLINE
Introduction
Literature References
Needs and Ideas
Product Specifications
Creating Concept
Concept Selection
Conclusion

INTRODUCTION

• Synthetic antipyretic
Background
drugs may have
• Fever is a condition
where the body
temperature rises, in
which it is controllable
at first but begins to
cause physical
discomfort when it
reaches 39.5oC.
• Antipyretic drugs work
by lowering the
temperature standards
to its normal value.

several side effects,
such as peptic ulcers,
duodenum ulcers,
kidney disorders and
liver. Furthermore,
they may be a
expensive in price
which pushes people
to use traditional
medicine instead,
which are more
simple and affordable
yet just as effective in
terms of prevention
and treatment.

wealth of natural resources. be safe for consumption. This product will also be expected to solve major problem: the symptom . the writers wish to create a new herbal medicine to reduce fever.Background • Based on Indonesia's • • Herbal treatment using medicinal plants has been empirically proven effective for treating the disease. Indonesia has a wealth of diverse biological resources and many of them contain useful drugs. and be packed in a practical and userfriendly manner. These will be antipyretic drugs which are expected to work effectively to treat fever. contain 100% herbal ingredients. Traditional medicine is the natural medicine that has been used for ages and known for its usefulness in strengthening the immune system as well as to cope with various diseases.

Problem Identification . such that it is not effective. and liver damage. impaired kidney. duodenal ulcers. Synthetic antipyretic drugs may require larger doses to achieve sustainable fever reduction. Synthetic antipyretic drugs may cause side effects such as gastric ulcers. 2.1.

Herbal antipyretics will be used to treat fever caused by fatigue and cold. Problem Boundary . 4. Herbal antipyretics will be created using 100% herbal ingredients that reduce the negative impacts to the consumers’ health condition. 3.1. The market target of this product will be adults (> 15 years old). The antipyretic created will be a product made from new ideas. 2.

LITERATURE REFERENCES .

mediators of inflammation . endothelial cells. others Endogenous pyrogens/ Pyrogenic cytokines IL1. microbial toxins.Mechanism of Fever Pyrogenic activators: infection. TNF.MIP-1 Exogenous & endogenous pyrogen will stimulate endothelium hypothalamu s to form prostaglandi n.6. immune reactions Monocytes/ macrophage s. . IFN.

Mechanism of Fever That prostagla ndin will increase thermosta t set point in hypothala mic thermoregulatory center. heat productio n FEVE R . Hypothalam us Central (mediators of fever) will assume that current temperature is lower than new temperature set point Elevated thermoregulatory set point Mechanis m to increase thermal  Heat conservati on.

Herbal AntiPyretic Ginger (Zingiber officinale) • Active compound : gingerol • Method of extracting : distillation and solvent distillation Aspirin Acetaminophen (paracetamol) Lengkuas (Alpinia galanga) • Active compound : galangoisoflavonoid • Method of extracting : filtration Ibuprofen Kencur (Kaempferia galanga L.) • • Sponging Undress a bit & remove excess clothes Set the temperature to a comfortable level Stay hydrated and eat right Active compound : ethyl-p-methoxycinnamate Method of extracting : filtration Feverfew (Tanacetum parthenium) • • Active compound : sesquiterpene lactones Method of extracting : extraction with acetonitrile/water (90:10. NonPharmaceutical Treatment.Pharmaceutical Medication. v/v) .

NEEDS AND IDEAS .

Characteristics of Respondents .

Characteristics of Respondents .

Characteristics of Respondents .

Characteristics of Respondents .

Characteristics of Respondents .

Characteristics of Respondents .

Expectation of New Product .

Expectation of New Product .

Expectation of New Product .

Needs: Grouping and ranking • Rank Indicator: Point Represent 5 Essential 4 Highly Desirable 3 Nice to Have 2 Not Impoortant 1 Undesirable Essential The needs are obliged to be present in the designed product Highly Desirable The needs are seen as expected benefits by most consumers Nice to Have The needs can be said as an “excitement” need Not Important The needs are less urgent for our goals Undesirable the needs are not really important or are not suitable with our goals .

List of Needs No. Needs  Essential 1 Herbal medicine which works fast 4 13 Herbal medicine which works effectively 15 Herbal medicine without artificial 18 sweetener 7 Herbal medicine which available in any 17 local stores 9 16 Herbal medicine which is affordable 22 Rank  5  5  5  5  5 .

List of Needs Needs No.   6 9   7 12 11   16 20 21   Rank Highly Desirable   Herbal medicine which has practical form Herbal medicine which is sweet Nice to have Herbal medicine which easy to consume Herbal medicine which reduce gastric acid Herbal medicine which is less viscous Not important Herbal medicine which is less bitter Herbal medicine’s flavor as it is Undesirable  4  4    3  3 3   2 2   .

PRODUCT SPECIFICATION .

N o Needs List of Metrics Metrics Ingredients Artificial 1 Herbal medicine has no artificial sweetener 8 sweetener concentration Product Performance Herbal medicine which works 1 quickly 4 1 Time taken to heal Herbal medicine which works 3 effectively 1 5 1 Herbal medicine which reduces Herbs Active 2 gastric acid Concentration 1 Herbal medicine which is less Viscosity 1 viscous Metrics Unit Rank mg/serving 5 Days 5 % 2 gr/s.cm 3 .

List of Metrics (con’t) Product Perception 1 Herbal medicine which is less Flavor 0 bitter 5 8 Herbal medicine which is Sweetener 1 sweet Concentration 4 1 9 2 0 Herbal medicine’s flavor as it Flavor is 2 1 Retailing 7 Herbal medicine which 1 Distribution available in any local stores 7 9 Subjective 2 mg/serving 2   Subjective 2 Unit/year 5 .

Needs Her bs Act ive Ti m S e Arti w ta F k fici e o al e e r Sw t n m to eet e h ene n r e e r al D e s i g n M as s & V ol u m e D i m e n s i o n V i s c o s it y D i s t P r r i i b c u e ti o n                     ●       F l a v o r Ingredients 18 1 4 Herbal medicine which has ● ●       no artificial sweetener Product Performance Herbal medicine which         ● works quickly Herbal medicine which .Specification of Product Concentrati on No .

Specification of Product (con’t) Packaging 6 2 3 Herbal medicine which has practical form and easy to         consume Product Perception Herbal medicine which is less 10   ● ●   bitter 5 8 Herbal medicine which is ● ● ●   14 sweet 19 20 Herbal medicine’s flavor as it ● ● ●   21 is Retailing 7 Herbal medicine which         17 available in any local stores 9 Herbal medicine which is 16         affordable 22   ●   ● ●                                                                 ●                 ●   .

Benchmark List No .cm ● ●● ●●●●● Packaging 6 Form Subjective 10 ml 15 ml 10 tablets 0 0 2 1 0 100 ●●●●● ●● 10 tablets 15 ml . Metrics Metrics Unit Tolak Paraceta Ibuprof Angin Antangi Own mol en Sidomunc n JRG Tablets Tablet ul Ingredients Artificial 18 sweetener mg/serving 0 0 0 concentration Product Performance 1 4 Time taken to Days 1.5 1 2 13 heal 15 Herbs Active 12 % 100 30 0 Concentration 11 Viscosity gr/s.

000.000 00 Rp 2.00 Rp Rp Rp 3.768.000.00 .00 Rp 2.0 400.470.00 2.000.500.00 1.Benchmark List (con’t) Product Perception 10 20 Flavor Subjective 21 5 Sweetener 8 mg/servin Concentratio g 14 n 19 7 Distribution 17 9 16 Price 22 Unit/year Rupiah ● ●● ● ● ●● 0 18900 0 0 800 (*) (*) (*) Retailing 786.

75 – 6.cm ●● - 6 Form Subjective Packaging Subjective Subjective 2 Dimension cm x cm x cm - Subjective (9-17) x (5.00. H.K.5) x 12 - .Table of Ideal Value & Marginal Value No .1. Metrics Metrics Unit Ideal Value Marginal Value Patents 800-1000 Surat Keputusan Kepala Badan POM No.05.5.4547 Ingredients 18 Artificial sweetener concentration mg/serving 2500-3000* Product Performance 1 4 13 15 Time taken to heal Days - 1-2 - % - 5670-16501 - 11 Herbs Active Concentration Viscosity gr/s.

000.00 Survey 2500-3000* Retailing 7 17 9 16 Distribution Price Unit/year Rupiah .00. H.000 - - Rp 1.4547 - 786.470.Table of Ideal Value & Marginal Value (con’t) Product Perception 10 20 Flavor 21 5 8 Sweetener 14 Concentration 19 Subjective mg/serving Subjective Subjective Subjective 800-1000 Surat Keputusan Kepala Badan POM No.000.00 – Rp 3.5.05.K.1.

cm 3 ● Form Subjective 4 Dimension cm x cm x cm Herbal medicine which reduce Herbs Active gastric acid Concentration Herbal medicine which is less 11 Viscosity viscous Packaging 12 6 2 Herbal medicine which has practical form and easy to Subjecti ve 8.Table of Product Specification No 18 1 4 13 15 Needs Metrics Metrics Unit Ingredients Artificial Herbal medicine which has no sweetener mg/serving artificial sweetener concentration Product Performance Herbal medicine which works fast Time taken to Days Herbal medicine which works heal effectively Rank Own 5 0 5 1.23 gr/s.5 % 2 4428.5 x 6 .

Product Perception Herbal medicine which is less 10 Flavor Subjective bitter 5 8 Herbal medicine which is Sweetener mg/serving 14 sweet Concentration 19 20 Herbal medicine’s flavor as it Flavor Subjective 21 is Retailing 7 Herbal medicine which Distribution Unit/year 17 available in any local stores 9 Herbal medicine which is affordable Subjectiv e Table of Product Specification (con’t) 2 0 Subjectiv e 5 400.000 Price Rupiah .

Creating Concept .

Splitting Problem

A.
Antipyretic

B. Herbal

C. As
Fatigue and
Cold
Medication

•How does the product specifications of existing Antipyretic Herbal Based
Medicine market needs today?
•How to design Antipyretic Herbal causes by fatigue and cold that have
effectiveness even better than existing Antipyretic nowadays?
•What kind of innovation replacement of Herbal Antipyretic will be accepted
by consumers?
•Could we use herbal active compound rather than chemical to make
Antipyretic Medicine?
•How to designHerbal Antipyretic that has less harm side effect than existing
Antipyretic nowadays?
•How to design Herbal Antipyretic that practice and easy to use than existing
Antipyretic nowadays?
•What is main problem in Antipyretic Herbal Based Medicine manufacture?

Existing Ideas

New Ideas

Combining Herbal Antipyretic Mindmap Concept .

Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding   prostaglandins in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in   the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes   inhibitor in the form of syrup. Anti-pyretic drug with ibuprofen as chemical active . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism   in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1   inhibitor in the form of syrup. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of impeding   prostaglandins in the form of syrup.Ideas Number Parasetamol Ibuprofen 1st idea 2nd idea 3rd idea 4th idea 5th idea Concept Predicate Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding   prostaglandins in the form of syrup.

Ideas Number 9th idea 10th idea 11th idea 12th idea 13th idea 14th idea 15th idea th Concept Predicate Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism in   the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes   inhibitor in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding   prostaglandins in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1   inhibitor in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in   the form of capsule. Anti-pyretic drug with ibuprofen as chemical active . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism in   the form of capsule. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes   inhibitor in the form of syrup.

Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1   inhibitor in the form of tablet Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in   the form of tablet. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes   inhibitor in the form of tablet. Anti-pyretic drug with ibuprofen as chemical active . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding   prostaglandins in the form of tablet.Ideas Number 19th idea 20th idea 21st idea 22nd idea 23rd idea 24th idea 25th idea Concept Predicate Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism   in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism   in the form of tablet. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes   inhibitor in the form of capsule.

Anti-pyretic drug with ethyl p-methoxycinnamate as herbal . Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes inhibitor in the form   of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding   prostaglandins in the form of candy. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of interleukin-1 inhibitor in the   form of infusing bag. Anti-pyretic drug with flavones as herbal active compound and with the mechanism of leukotrienes inhibitor in the form of   infusing bag.Ideas Number 29th idea 30th idea 31st idea 32nd idea 33rd idea 34th idea 35th idea Concept Predicate Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism in the form of   tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of anti-histamine in the form   of infusing bag. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding   prostaglandins in the form of infusing bag.

Anti-pyretic drug with hydrogel as synthetic active compound and with the mechanism of removing heat by heat transfer in   the form of patch.Ideas Number 39th idea 40th idea 41st idea 42nd idea 43rd idea 44th idea 45th idea th Concept Predicate Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding R prostaglandins in the form of effervescent. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of interleukin-1 inhibitor in R the form of effervescent. Anti-pyretic drug with flavones as herbal active compound and with the mechanism of leukotrienes inhibitor in the form R of effervescent. Anti-pyretic drug with menthol as herbal active compound and with the mechanism of removing heat by heat transfer in F the form of lotion. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding   prostaglandins in the form of syrup. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal . Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of anti-histamine in the form R of effervescent.

Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of interleukin-1 V inhibitor in the form of capsule. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of anti-histamine V in the form of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of anti-histamine V in the form of capsule. Anti-pyretic drug with flavones as herbal active and with the mechanism of leukotrienes inhibitor in the form of V tablet.Ideas Number 49th idea 50th idea 51st idea 52nd idea 53rd idea 54th idea 55th idea Concept Predicate Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of V impeding prostaglandins in the form of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active and with the mechanism of interleukin-1 V inhibitor in the form of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of V impeding prostaglandins in the form of capsule. Anti-pyretic drug with flavones as herbal active and with .

Combining & Eliminating Herbal Antipyretic Mindmap Concept .

Concept generation .

Developing Ideas • Imagination • Modification Innovation • Active Compound • Flavour • Form of the product • Effectiveness Discover the needs • Customer • Supplier • Internal researcher • Competitor Generat ed Concept s Pre-Evaluate .

Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of impeding prostaglandins in the form of syrup.Ideas Number Parasetamol Ibuprofen 1st idea 2nd idea 3rd idea 4th idea 5th idea 6th idea Concept Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding prostaglandins in the form of syrup. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of impeding prostaglandins in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1 inhibitor in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of syrup. . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding prostaglandins in the form of syrup.

Anti-pyretic drug with ibuprofen as chemical active compound and . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding prostaglandins in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1 inhibitor in the form of capsule.Ideas Number 9th idea 10th idea 11th idea 12th idea 13th idea 14th idea 15th idea 16th idea Concept Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism in the form of syrup. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of impeding prostaglandins in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism in the form of capsule. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of syrup. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in the form of capsule.

Anti-pyretic drug with ibuprofen as chemical active compound and . Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of tablet. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of impeding prostaglandins in the form of tablet. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of interleukin-1 inhibitor in the form of tablet Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of anti-histamine in the form of tablet.Ideas Number 19th idea 20th idea 21st idea 22nd idea 23rd idea 24th idea 25th idea 26th idea Concept Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism in the form of capsule. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of kinin antagonism in the form of tablet. Anti-pyretic drug with paracetamol as chemical active compound and with the mechanism of impeding prostaglandins in the form of tablet. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of capsule.

Anti-pyretic drug with flavones as herbal active compound and with the mechanism of leukotrienes inhibitor in the form of infusing bag. . Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of infusing bag. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of interleukin-1 inhibitor in the form of candy. Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of leukotrienes inhibitor in the form of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of candy. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of interleukin-1 inhibitor in the form of infusing bag.Ideas Number 29th idea 30th idea 31st idea 32nd idea 33rd idea 34th idea 35th idea 36th idea Concept Anti-pyretic drug with ibuprofen as chemical active compound and with the mechanism of kinin antagonism in the form of tablet. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of anti-histamine in the form of infusing bag.

Anti-pyretic drug with flavones as herbal active compound and with the mechanism of leukotrienes inhibitor in the form of syrup. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of anti-histamine in the form of syrup. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of syrup. .Ideas Number 39 idea th 40th idea 41st idea 42nd idea 43rd idea Concept Anti-pyretic drug with hydrogel as synthetic active compound and with the mechanism of removing heat by heat transfer in the form of patch. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of interleukin-1 inhibitor in the form of syrup.

Concept Screening and Joining .

This step is called a concept screening. This method introduced by Stuart Pugh on 1980 and called Decision Making Matrix This phase main objective is to narrow down the concepts that existed and reduce the many product concept ideas generated to a relative few that will get additional refinement and analysis .Concept Screening and Joining After we generate the concepts. we will select the most feasible object and eliminate the impossible.

Rate the concepts. . • + is given for better than reference concept.Concept Screening and Joining: Steps Prepare the selection/ screening matrix. • Selection criteria selection is done on the basis of things that distinguish each concept ideas. • Ranking the concepts is needed to be done as objectively as possible using the concept rating. • – is given for concepts that are worse than reference concept. • Idea concepts will be compared to benchmark brand as reference concept. • 0 is given for concepts that are equal than reference concept. • Concept rating of any ideas for each selection criteria then is added to the total score. Rank the concepts • Selection criteria must relate to key customer needs.

Concept Screening and Joining: Steps (con’t) Combine & improve the concepts • It is needed to find if there are any generally good concepts that are downgraded by one feature and to find if it possible for 2 concepts to be combined to preserve the “better than” features while simultaneously removing any “worse than” features. while the concept with further value above than 1 are being continued by doing refinement and the merger of certain concepts to improve the rating analysis of that concept. Reflect on the results and process • All team members need to reflect on current results to find if it is comfortable enough with the decisions that have been made. the manufacturer/ designer team members should find . Select one or • Ideas with the total score is below than 1 are more concepts for decided not to be realized. If it’s not comfortable.

Severe dizziness . Active compound that heal either inflammatory or go to Effectiveness Hypothalamus to Decrease b. Headache f. Easy to produce Product a. Dried mouth e. Easy to swallow b. Easy to carry Easy to Use c. Practical in serving d. Simple composition Manufacture b. Save to be consumed at any time Easy to a. Sore throat g. Stomach cramp c. Easy to release in the body Fever c. Drowsiness b. Containing right amount of dosage a.Concept Screening and Joining: Selection criteria a. Nausea Side Effects d.

Concept Screening and Joining: Matrix Of Concept Screening Ideas Paraseta mol Ibuprofe n 1st idea 2nd idea 3rd idea 4th idea 5th idea 6th idea 7th idea 8th idea 9th idea 10th idea th Easy to Use Product Easy to Side Scor Effectivenes Manufacture Effects e s 0 0 0 0 0 0 0 0 -1 -1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -1 -1 -1 -1 -1 0 0 0 0 0 -1 -1 -1 -1 -1 Result Reference 2nd Reference Not go Not go Not go Not go Not go Not go Not go Not go Not go Not go .

Concept Screening and Joining: Matrix Of Concept Screening Ideas Paraseta mol Ibuprofe n 14th idea 15th idea 16th idea 17th idea 18th idea 19th idea 20th idea 21st idea 22nd idea rd Easy to Use Product Easy to Side Scor Effectivenes Manufacture Effects e s Result 0 0 0 0 0 Reference 0 0 0 -1 -1 0 0 0 0 0 0 -1 -1 -1 -1 -1 -1 0 0 0 0 0 0 0 0 -1 -1 -1 -1 -1 -1 -2 -2 -2 -2 2nd Reference Not go Not go Not go Not go Not go Not go 0 -1 0 -1 -2 Not go 0 0 -1 -1 0 0 0 0 -1 -1 Not go Not go .

join Go. join Not go Not go Not go Not go .Concept Screening and Joining: Matrix Of Concept Screening Ideas Paraseta mol Ibuprofe n 27th idea 28th idea 29th idea 30th idea 31st idea 32nd idea 33rd idea 34th idea 35th idea 36th idea th Easy to Use Product Easy to Side Scor Effectivenes Manufacture Effects e s 0 0 0 0 0 0 0 0 -1 -1 0 0 0 0 -1 -1 -1 -1 1 1 -1 -1 -1 -1 1 1 1 1 -1 -1 0 0 0 0 0 0 -1 -1 -1 -1 -1 -1 -1 -1 1 1 1 1 1 1 -2 -2 -2 -2 1 1 0 0 0 0 Result Reference 2nd Reference Not go Not go Not go Not go Go.

Concept Screening and Joining: Matrix Of Concept Screening Ideas Paraseta mol Ibuprofe n 40th idea 41st idea 42nd idea 43rd idea Easy to Use Product Easy to Side Scor Effectivenes Manufacture Effects e s 0 0 0 0 0 0 0 0 -1 -1 1 1 1 1 0 0 0 0 0 0 0 0 1 1 1 1 2 2 2 2 Result Reference 2nd Reference Go. join . join Go. join Go. join Go.

Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of syrup. Anti-pyretic drug with flavones as herbal active compound and with . Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of interleukin-1 inhibitor in the form of syrup.Concept Screening and Joining: Selected concept that passed in concept screening Ideas 31st idea 32nd idea 40th idea 41st idea 42nd idea 43rd Concept Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of infusing bag. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of anti-histamine in the form of syrup. Anti-pyretic drug with ethyl p-methoxycinnamate as herbal active compound and with the mechanism of interleukin-1 inhibitor in the form of infusing bag.

Concept Scoring and Selection .

rating for all concepts from all selection criteria was summed up and became the net score The concept that has the highest score would be chosen as the best concept .Concept Scoring After the concept being screened and joined. we rate each concept.

Concept Scoring Anti-pyretic drug with herb active compound and with the mechanism of impeding prostaglandins in the form of syrup Anti-pyretic drug with herb active compound and with the mechanism of impeding leukocyt pyrogenes in the form of syrup Anti-pyretic drug with herb active compound and with the mechanism of impeding histamine in the form of syrup Anti-pyretic drug with herb active compound and with the mechanism of impeding kinin in the form of syrup Anti-pyretic drug with herb active compound and with the mechanism of impeding leukotrienes in the form of syrup .

Practically to use (20%) 1: Product can’t be consumed anytime. need certain instruments to be consumed and easy to swallow 3: Can be directly consumed. need certain instrument to be consumed and hard to swallow 4: Can be directly consumed. need certain instrument to be consumed and easy to swallow Manufacturability (15%) 1: 2: 3: 4: Hard to produce Not that hard to produce Not that easy to produce Easily produce . need certain instruments to be consumed and hard to swallow 2: Product can’t be consumed anytime.

Effectiveness to reduce fever (30%) 1: Medication that doesn’t help reduce the fever 2: External medication that doesn’t heal neither inflamatory nor hipotalamus 3: Active compound reduce inflamatory 4: Active compound can go directly to hipotalamus Side Effect (15%) 1: 2: 3: 4: Product Product Product Product has lethal side effect hasn’t lethal side effect. but complicated sickness has little side effect nearly not causing harmful side effect .

Concept Scoring SubCriteria Criteria Weights Results Anti-pyretic drug with ethyl pmethoxycinnamate as herbal active compound and with the mechanism of impeding prostaglandins in the form of infusing bag.2 4 0.6 4 1.8 3 .4 4 0. Anti-pyretic drug with ethyl pmethoxycinnamate Effectivenes Manufactura s to reduce Side Effect bility Fever Scor 20% 15% 30% 20% e Weight Weight Ratin Weighte Ratin Ratin Weighte Rating ed ed g d Score g g d Score Score Score Practicality to Use 2 0.

8 3.Concept Scoring (con’t) Effectiveness to reduce Side Effect Fever Sco Criteria Weights 20% 15% 30% 20% re Weight Weight Ratin Weighte Weighte Ratin Results Rating ed Rating ed g d Score d Score g Score Score Anti-pyretic drug with ethyl pmethoxycinnamat e as herbal active compound and 0.45 4 1.25 with the 4 mechanism of impeding prostaglandins in the form of syrup.2 4 0.8 3 0. Anti-pyretic drug with ethyl pmethoxycinnamat e as herbal active SubCriteria Practicality Manufactura to Use bility .

Anti-pyretic drug with flavones as herbal active compound and SubCriteria .Concept Scoring (con’t) Effectivenes Practicality Manufactura s to reduce Side Effect to Use bility Fever Sco Criteria Weights 20% 15% 30% 20% re Weight Weight Ratin Ratin Weighte Ratin Weighte Results ed Rating ed g g d Score g d Score Score Score Anti-pyretic drug with ethyl pmethoxycinnamate as herbal active compound and 4 0.25 with the mechanism of antihistamine in the form of syrup.8 3 0.8 3.2 4 0.45 4 1.

good to be consumed anytime and practical Easy to Effectiven Manufactur ess e Simple manufacture process. easy drug composition manufacture process Effective Side Effect Drowsines s. and as leukotrienes inhibitor in the form Easy to Use Easy to carry.Selected Concept Idea Anti-pyretic drug with with ethyl pmethoxycinnamate and flavones as herb active compound and with the mechanism of impeding prostaglandins. as interleukin-1 inhibitor. blurry vision . as antihistamine.

Concept Testing .

Concept Testing • Affirming whether the chosen concept can be accepted by customers. • Test done through surveys: – Population: 56 people (48% of them students) – Format: online questionnaires – Concept described in written form .

. • The concept indeed fits within the customers’ needs. so it can compete with other existing antipyretic products.Customers’ Responses Interest in Buying Liquid Herbal Antipyretic in Sachet with Natural Sweetener Ye s • 91% respondents showed interest in buying liquid herbal antipyretic in sachet with natural sweetener.

Perceptual Map Practicality to Use 4 2 Side Effect 0 Effectiveness Manufacturability Herbal Antipyretic Paracetamol Ibuprofen Tolak Angin Sidomuncul Antangin JRG .

Perceptual Map Herbal Paracetam Antipyret Ibuprofen ol ic Practicality to Use Manufactura bility Effectiveness Side Effect Tolak Angin Antangin JRG Sidomuncul 4 3 3 4 4 3 2 2 3 3 4 4 4 1 4 1 4 3 4 3 .

. herbal medicine will not require too much advanced machinery. while paracetamol and ibuprofen are usually packaged in bottle. Tolak Angin and Antangin will be packaged in sachet which is easy to carry and can be consumed anytime. Meanwhile. • Manufacturability: Synthetic drugs require a long process of production. which means it requires more advanced machinery for more complicated processes and requires more cost. therefore less practical to consume.Perceptual Map • Practicality to Use: In liquid form.

Tolak Angin and Antangin. synthetic drugs are shown to have more dangerous possible side effects. • Side effect: Despite their effectiveness. however. their effectiveness in lowering fever is still lower. Meanwhile. Therefore.Perceptual Map • Effectiveness: Synthetic drugs are already established as effective antipyretics which are commonly consumed. do not focus in its antipyretic properties to lower fever. but rather to prevent or cure from catching cold. herbal medicine are less likely to have such dangerous side effects because of their natural properties. .

CONCLUSION .

we select several needs that must be contained in our product. Moreover. Consuming herbal antipyretics can be an alternative in order to prevent the damages of consuming synthetic antipyretic drugs in the long term.Conclusion 1. 2. From respondents’ statements. antipyretic which is not only affordable but also available in any drug stores 4. herbal antipyretic which works quickly and effectively. 100% fresh herbal-made antipyretic. antipyretic without artificial sweetener. Herbal antipyretic drugs have less side effects be compared with synthetic antipyretic. 3. There are. respondents like herbal antipyretic which .

. it is found that the selected concept can be accepted by prospective customers. manufacturability. and side effects. After concept testing through questionnaires. The product’s concepts are evaluated based on the parameters of practicality to use. 7.Conclusion 5. 6. Based on the scoring from the aforementioned parameters. seen from 91% of them showing interest in buying the herbal antipyretic. the selected concept of the product is antipyretic drug with herb active compound and with the mechanism of impeding prostaglandins in the form of syrup. effectiveness.

Thank You .