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_ _ (ALDO INCREASES EC FLUID VOLUME) ( physioweb.edu) .med.uvm.

THE ADRENAL GLAND: CORTISOL CORTISOL .

Glukokortikoid Biosintesis kortisol • ACTH ACTH +R  mengaktifkan adenil siklase  ↑ AMP intrasel  mengaktifkan protein kinase A  fosforilasi kolestril ester hidrolase menjadi kolesterol bebas .

Glukoneogenesis .lipolisis $ Efek Permisif $ Efek antiinflamasi (Fisiologi ganong...proteolisis .Fisiologi sheerwood) .Efek Glukokortikoid • Efek fisiologik • Efek Farmakologik $ Efek Metabolik .

Glukokortikoid • Efek: – Merangsag glukoneogenesis hati  ↑ kadar glukosa darah – Menghambat penyerapan & penggunaan glukosa olh bnyk jar. kec otak – Merangsang penguraian protein – ↑ lipolisis di jar adiposa  ↑ as lemak darah – ↓jmlh eosinofil dlm darah dg ↑ sekuestrasinya di limpa & paru .

– ↓hitung limfosit dlm darah dg menghambat aktivitas mitosis limfosit • Mekanisme kerja: – Glukokortikoid + R  transkripsi DNA  translasi mRNA  sintesis enzim yg menubah fungsi sel .

med.edu .CORTISOL AND FOODSTUFF METABOLISM Physioweb.uv m.

Imun Monosit Menghambat proliferasi Skin n Connective Tissue Cardivascular Antiproliferatif for fibroblast Heart Increased Contractility (Basic n Clinical endrocrinology .Efek yang LAin Target Sistem Spesific Target Physiologic Function S.

Breakdown of Connective Tissue and Bone. 2. transaminases) Overall Unmasking of Diabetes Mellitus www. Metabolism (see below): increased incidence of Diabetes Mellitus. Carbohydrate Increased gluconeogenesis from protein Reduced glucose uptake by muscle Increased appetite Fat Peripheral mobilizatoion Central (“axial”) deposition (“Buffalo Hump”) Increased appetite: body weight/ Fat increases Protein Increased muscle protein breakdown: muscle wasting Increased synthesis of liver gluconeogenic enzymes (e. Examples: cardiovascular system cannot respond to exercise. liver cannot respond to epinephrine. 1.CORTISOL EFFECTS OF DEFICIT.g. 3. kidney cannot respond to a water load or dehydration.medicalstu dent. Excess can have mineralocorticoid effects on electrolytes (due to structural similarities between cortisol and aldosterone). EFFECTS ON FOODSTUFF METABOLISM. 1. EFFECTS OF EXCESS.com . 4. Suppression of Immune and inflammatory reactions. Any major stress to the body can lead to death. Cells/Organs/Systems cannot respond to external signals/stresses.

Anterior (ACTH) Glukosa drh As.Pengaturan sekresi Glukokortikoid Stress Irama diurnal (-) Hipotalamus (CRH) (-) H.amino drh Korteks Adrenal Kortisol As.lmk drh Fisiologi Sheerwood .

c om Physioweb.med.DAILY SECRETION: CORTISOL Pulsatile signals from pituitary Diurnal changes in the feedback SET POINT www.medicalstudent.e .uvm.

MECHANISM OF ACTION: CORTISOL .