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NHL VS.

HL

COMPARE & CONTRAST


CATEGORY

NHL

HL

REED-STERNBERG
CELL

ABSENT

PRESENT

ORIGIN

B/T CELL

B CELL

PATHOGNOMONIC SIGN ENLARGED LN

ANY LN OR ORGAN

AGE

>60

15-24; >60

SX

PAINLESS SWELLING

PAINLESS SWELLING

AREA

THROUGHOUT BODY

NECK, UNDERARM, CHEST

PROGRESS

ADVANCED

SLOW

NON-HODGKINS
LYMPHOMA

TYPES
B-CELL LYMPHOMA
DIFFUSE LARGE BCL
PRIMARY MEDIASTINAL
INTRAVASCULAR

FOLLICULAR L
CLL/SLL
MANTLE CELL L

MARGINAL ZONE BCL


EXTRANODAL MZBCL
NODAL MZBCL
SPLENIC MZBCL

BURKITT L
LYMPHOPLASMACYTIC L
HAIRY CELL LEUKEMIA
PRIMARY CNS L

RISK FACTORS
AGE
GENDER
RACE, ETHNICITY,
GEOGRAPHY
EXPOSURE TO
CHEMICALS
RADIATION

IMMUNODEFICIENCY
AUTOIMMUNE DSS
INFXN
OBESITY
IMPLANTS

S/SX
ENLARGED LN
SWOLLEN ABDOMEN
FEELING OF FULLNESS
CHEST PAIN
FATIGUE
ANEMIA

SOB/COUGH
LEAKAGE
FEVER
WT. LOSS
NIGHT SWEATS

DX
PE
BIOPSY
LAB TEST
FLOW CYTOMETRY
IMMUNOHISTOCHEM
CYTOGENETICS
MOLECULAR GENETIC TESTS
BLOOD TEST

IMAGING

STAGING (ANN ARBOR SS)


S1 1 LN; 1 AREA OF SINGLE ORGAN OUTSIDE LS
S2 >2 LN SAME SIDE OF DIAPHRAGM; EXTEND FROM
SINGLE GROUP INTO NEARBY ORGAN/OTHER LN ON
SAME SIDE DIAPHRAGM
S3 LN BOTH AREA; SPREAD TO ORGAN NEXT TO LN,
SPLEEN OR BOTH
S4 - METASTASIS

STAGING
BULKY DSS
A vs. B

TX (CHEMO)
Alkylating agents
Cyclophosphamide
(Cytoxan)
Chlorambucil
Bendamustine (Treanda)
Ifosfamide (Ifex)

Corticosteroids
Prednisone
Dexamethasone
(Decadron)

Platinum drugs
Cisplatin
Carboplatin
Oxaliplatin

Purine analogs
Fludarabine (Fludara)
Pentostatin (Nipent)
Cladribine (2-CdA,
Leustatin)

Anti-metabolites
Cytarabine (ara-C)
Gemcitabine (Gemzar)
Methotrexate
Pralatrexate (Folotyn)

Others
Vincristine (Oncovin)
Doxorubicin (Adriamycin)
Mitoxantrone
Etoposide (VP-16)
Bleomycin

IMMUNOTHERAPY
Antibodies that
target CD20
Rituximab (Rituxan)
Obinutuzumab (Gazyva)
Ofatumumab (Arzerra)
Ibritumomab tiuxetan
(Zevalin)

Antibodies targeting
CD52
Alemtuzumab
(Campath)

Antibodies that
target CD30
Brentuximab vedotin
(Adcetris)

Interferon
Immunomodulating
agents
Thalidomide (Thalomid)
Lenalidomide (Revlimid)

TX
RADIATION
HIGH-DOSE CHEMO
STEM CELL
SURGERY