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Adenocarcinoma of the

Prostate

BIO 316 Summer 2004


Jared Young

Overview:

Background

Treatments

Prognosis

Future Treatments

Prevention

Participation and Info

Background:
Prostate:

Location - between bladder and


external urinary sphincter.

Purpose - produce fluid that


accompanies ejaculate.

Statistics:

New Cases - est. 230,110 in 2004.


Deaths - est. 29,900 in 2004.
(2nd leading cause of cancer death)

70% diagnosed in men over age of 65.

5-10% familial predisposition

41% of men age 50 or older have had


PSA test within past year.

American Cancer Society 2004

Risk Factors:

Age - over 65.

Ethnicity - African American and


Jamaican

Family History - 5-10%

Geography Common - North America and Western Europe.


Rare - Asia and South America

Occupation - farmers, tire workers,


painters.
(exposure to cadmium)

Diet - high fat (animal fat), high


calcium intake

Weight - greater weight = greater risk

Treatments:

Radiation therapy
- External Beam
- Conformal
- Brachytherapy

Radical prostatectomy

Cryoablation

Hormonal therapy
- Androgen ablation

Prognosis:

Stages - Local - confined to prostate capsule


- Regional spread to pelvic lymph nodes
- Distant bone (90%), pulmonary system (10%)

86% discovered in local and regional stages

5-year relative survival rate local/regional (100%), distant (34%).

All stages 10-yr. relative survival rate (84%), 15-yr. (56%).

Impotency

No Cure

American Cancer Society 2004

Future Treatments:

Differentiation Therapy

Signal Transduction Inhibitors

Gene Therapy

Angiogenesis Inhibitors

Prevention:

No proven prevention measures

PSA/DRE screening starting at age 50.

Dietary Prevention
- soy protein
- Micronutrients Vitamins E, D and
Selenium.
- Lycopene tomatoes and beets
- low fat intake

Participation and Info:

www.cancer.gov
www.cancer.org
www.ustoo.org
http://cis.nci.nih.gov/
http://www.prostate-cancer.org/
http://www.prostate.com/
http://www.prostateinfo.com/
http://www.cdc.gov/cancer/prostate/prostat
e.htm
http://www.cancernews.com/male.htm