Professional Documents
Culture Documents
ines
Ishaque PK
PondichErry university
Introduction
B-Cells
b) T-Cells
Macrophages
d) Neutrophils
Basophils
f) Eosinophils
Endothelial cells
h) Mast cells
Overview
Properties
Cytokines
exhibit
the
attributes of:
Pleiotropy,
Redundancy,
Synergy,
Antagonism,
cascade
induction,
which permit
them
to
regulate
cellular
activity in a
coordinated,
Nomenclature
Chemokines
mediate
chemoattraction
Classification
Lymphokines
Interleukins (IL)
Monokines
Interferons (IFN)
colony stimulating factors (CSF)
Tumor Necrosis Factors-Alpha and Beta (TNF)
Other.
# Type-1 & Type-2
Type-1 cytokines are cytokines produced by Th1 T-helper
cells.
Include IL-2 (IL2), IFN-gamma (IFN-G), IL-12 (IL12) & TNFbeta (TNF-b).
Type-2 cytokines are those produced by Th2 T-helper
cells.
Include IL-4 (IL4), IL-5 (IL5), IL-6 (IL6), IL-10(IL10), and IL13 (IL13).
# Mediators of natural immunity:
TNF-, IL-1, IL-10, IL-12, type I interferons (IFN- and IFN), IFN-, and chemokines.
# Mediators of adaptive immunity:
IL-2, IL-4, IL-5, TGF-, IL-10 and IFN-.
Lymphokines
Lymphokinesinclude:
Actions of lymphokinesinclude:
Activates B cells, inhibitsmacrophagefunction :IL10.
Activationofneutrophils,eosinophils, andmonocyte
/macrophages:GM-CSF.
Bone resorption : osteoclast activating factor
Bone marrowgrowthanddifferentiationof
immune cells :IL-3
B cellgrowthanddifferentiation:IL-4.
B
celldifferentiation,activatessomemicrophages(pm
n) :IL-5
Co-stimulatorofT cells, inducesgrowthinB
cells:IL-6
Inflammation, fever,catabolismand
cachexia,activationof somemicrophages:TNF
Monokine
Amonokineis
a
type
ofcytokineproduced
primarily bymonocytesandmacrophages.
Examples
includeinterleukin
necrosis factor-alpha.
Other
monokines
include
alpha
and
betainterferon, andcolony stimulating factors.
1andtumor
Interleukeins
Interferons
Interferons play an important role in the first
line of defense against viral infections.
They are part of thenon specific immune
systemand are induced at an early stage in
viral infection before the specific immune
system has had time to respond.
Interferons are made by cells in response to
an appropriate stimulus, and are released into
the surrounding medium; they then bind to
receptors on target cells and induce
transcription ofapproximately 20-30 genes in
the target cells, and this results in an antiviral state in the target cells.
Types of interferon
Chemokines
Classification
Cytokine Receptors
References
Immunology by Kuby
http://pathmicro.med.sc.edu/mobile/m.immuno13.htm
http://www.rndsystems.com/research_topic.aspx?
r=14
http://www.ebioscience.com/resources/pathways/cyto
kine-network.htm
http://www.prospecbio.com/Cytokines
http://en.wikipedia.org/wiki/Cytokine