Kluver Bucy Syndrome

TEMPORAL LOBE LESION

Cerebrum
1.

Largest part of the brain Learning and Senses 2 hemispheres- Right and Left Connected by the Corpus Callosum Right side controls- left side Left side controls right side of body Four sections - LOBES 1. Frontal Lobe 2. Parietal Lobe 3. Occipital Lobe 4.Temporal Lobe

Refer back to this labeled version as needed

Klüver-Bucy syndrome is a behavioral disorder that occurs when both the right and left medial temporal lobes of the brain malfunction. The amygdala has been a particularly implicated brain region in the pathogenesis of this syndrome. 

Klüver-Bucy syndrome

A Disorder produced by bilateral temporal lobectomy, characterized by placidity, socially inappropriate sexual activity, compulsive orality, a decreased ability to recognize people, and memory deficits.

Symptoms The list of symptoms differs somewhat by source. Generally included are the following:

Docility. Characterized by exhibiting diminished fear responses or reacting with unusually low aggression. This has also been termed "placidity" or "tameness". Dietary changes. Characterized by eating inappropriate objects and/or overeating (e.g. bulimia). Hyperorality. This is described as "an oral tendency, or compulsion to examine objects by mouth".

Hypersexuality. Characterized by a heightened sex drive or a tendency to seek sexual stimulation from unusual or inappropriate objects. Visual agnosia. Characterized by an inability to recognize familiar objects or people. Hypermetamorphosis, characterized by "an irresistible impulse to notice and react to everything within sight". Lack of emotional response, diminished emotional affect. Memory loss.

It is rare for humans to manifest all of the identified symptoms of the syndrome; three or more are required for
diagnosis.Among humans, the most common symptoms include placidity, hyperorality and dietary changes. They may also present with an inability to recognize objects or inability to recognize faces or other memory disorders.

Klüver-Bucy syndrome In an attempt to reduce aggression in monkeys, Klüver &Bucy (1939) inflicted large bilateral lesions of the inferior temporal lobe of wild monkeys housed in a laboratory These lesions affected high level visual association cortical areas, amygdala, hippocampus

Klüver-Bucy syndrome
Symptoms of Klüver-Bucy syndrome PSYCHIC BLINDNESS did not appreciate the significance ofwhat they were looking at HYPERMETAMORPHOSIS compulsively approach all items they encounter ORAL TENDENCIES they put everything they found in theirmouth

CHANGE IN EMOTIONAL BEHAVIOR
became tame,emotionally bland, SHOWED LITTLE FEAR of humans or naturally fear-invoking stimuli (i.e. snakes)

CHANGES IN SEXUAL BEHAVIOR
indiscriminantly sexual

Klüver-Bucy follow-ups We now know that many of these changes are dependent upon (bilateral) amygdala lesions In subsequent work, lesions of the amygdala in particular made monkeys fearless of e.g. humans or snakes, and affectively flat, tame Also disrupted social interaction (changes in sexual behavior most probably due to damage to the pyriform cortex, not related to amygdala)

What is Klüver-Bucy Syndrome?

Klüver-Bucy syndrome is a rare behavioral impairment that is associated with damage to both of the anterior temporal lobes of the brain. It causes individuals to put objects in their mouths and engage in inappropriate sexual behavior. Other symptoms may include visual agnosia (inability to visually recognize objects), loss of normal fear and anger responses, memory loss, distractibility, seizures, and dementia. The disorder may be associated with herpes encephalitis and trauma, which can result in brain damage.

As regards his visual functions, the patient seemed unable to recognize a wide variety of common objects. He examined each object placed before him as though seeing it for the first time, explored it repetitively and seemed unaware of its significance . he seemed unable to distinguish between relevant and irrelevant objects and actions. Behavioral patterns were distinctly abnormal. He exhibited a flat affect, and, although originally restless, ultimately became remarkably placid. He appeared indifferent to people or situations On occasion he became facetious, smiling inappropriately and mimicking the gestures and actions of others.

All objects that he could find were placed in his mouth and sucked or chewed he ingested virtually everything within reach, including the plastic wrapper from bread, cleaning pastes, ink, dog food and feces. The patient s sexual behavior was a particular source of concern while in hospital. Although vigorously heterosexual prior to his illness, he was observed in hospital to make advances toward other male patients by stroking their legs and inviting fellatio by gesture; at times, he attempted to kiss them. Marlowe, Mancall, & Thomas, 1975, pp. 55-56