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ENDOCRINE AND METABOLIC SYSTEM

( 7 SKS )
Dr. ANNA SARI DEWI, SPOG

Sistem Endokrin dan Metabolisme


Fakultas Kedokteran UMI Makassar

What is the Endocrine System ?


1.
2.

3.

A chemical messenger or hormone produced by an


organ is released into circulation to produce an effect
on a distant target organ
An integrated network of multiple organs derived from
different embryologic origins that release hormone
ranging from small peptides to glycoprotein which
exert their effects either in neighboring or distant target
cells
Three basic component make up the core of the
endocrine system :
a. Endocrine gland
b. Hormone
c. Target organs

Definitions
Endocrinology- the study of hormone and
glandular abnormalities- diabetes, thyroid
problems, sex, adrenal etc.
Hormones- biologically active substances
secreted by glands.
Endocrine- hormones that have a biological
effect far away.
Paracrine - hormones that have a biological
effect nearby.
Autocrine - hormones that have a local effect

The endocrine organ are located throughout the body

Some of the key functions of EM System include :


Regulation of sodium and water balance and control of
blood volume and pressure
Regulation of calsium and phosfat balance to preserve
extracellular fluid concentrations required for cell membrane
integrity and intracellular signaling.
Regulation of energy balance and control of fuel
mobilization, utilization and storage to ensure that cellular
metabolic demand are met.
Coordination of the host hemodynamic and metabolic
counterregulatory responses to stress
Regulatory of reproduction, development, growth and
senescence.
Is to coordinate and integrate cellular activity within the
whole body by regulating cellular and organ function
throughout life and maintain homeostasis.

Hemodynamic and metabolic counterregulatory response


to stress

Hormones are essential for normal growth,


development, metabolism, energy,
reproduction etc.
Hormones are tightly regulated by multiple
systems
Both over and underproduction of
hormones leads to clinical disease

MODUL

1. Diabetes Mellitus :
1.1. Type 1 Diabetes
1.2. Screening and diagnosis type 2 DM
1.3. IFG/IGT
1.4. Coma : KAD and HONC, Lactic acidosis
1.5. GDM
1.6. Diabetic Foot
1.7. DM and Its Related diseases
1.8. Hypoglycemia
1.9. Micro and Macrovascular complications
1.10. Neuropathy diabetic

2. Modul Obesity and MetSyn


2.1.
2.2.
2.3.
2.4.

Obesity and metabolic diseases


PCOS
Lipidology
The ADIPOSE Tissue

3. MODUL INTEGRATED CASES


3.1. Steroids and its related to metabolic and
endocrine diseases
3.2. Osteoporosis
3.3. Cardio-Metabolic Diseases

4. THYROID
4.1. Graves Disease
4.2. Hypothyroidism ( Hashimoto, thyroiditis etc )
4.3. Periodic paralysis thyrotoxicosis ( PPT)
4.4. Hypo and hyperthyroid in pregnancy
4.5. Thyroid Storm
4.6. Thyroid Nodule
4.7. IDD
5. MODUL PARATHYROID :
5.1. Hypocalcemic Crisis
5.2. Hypercalcemia
5.3. Metabolic bone disease

6. MODUL PITUITARY
6.1. Acromegaly / Gigantism
6.2. SIADH
6.3. Hyperprolactinemia
6.4. Diabetes Insipidus
6.5. Empty Sella Syndrome
6.6. Cushing disease
7. ADRENAL :
7.1.
7.2.
7.3.
7.4.

Addison disease
Cohn Syndrome
Adrenal crisis
Pheochromocytoma

8. Modul Paediatric Endocrinology


8.1. Pediatric growth and development
8.2. Disease of pituitary in child and adolescent
8.3. Hypo and hyperthyroidism in child
8.4. Adrenal diseases in child
8.5. Sexual dysfunction in child

Acromegaly

Cushings Syndrome

Topic of CSL
1. Thyroid Examination
2. Antrhopometric
3. Insulin Injection ( demonstration )

Thyroid examination

The insulin injections

Topic of PBL
1. Weight loss :
a. Graves Diseases
b. Diabetes Mellitus
2. Polyuria :
a. Diabetes Insipidus
3. Obesity :
a. Metsyn
b. Acromegaly

EVALUATION
1. Prac. lab
2. CSL
3. Tutorial/PBL
Prasyarat
4. Theory exam/Final
Passing Grade : 56

: 25 %
: 25 %
:
: 50 %

Time Allocation (1 )
Items

Lecture

Prac.

Anatomy

Histology

Biochemystry

Physiology

Clin.Path

Pathology

Nutrition

Pharmacol

Radiology

PBL

CSL

Time Allocation (2 )
Items

Lecture

Prac.

PBL

Paediactic

10

Int.Med

22

12

Opthalmolol

Neurologyst

Obstetric

Others

TOTAL

65

12

12

CSL

12

The Dream Team


Prof. Dr. John MF Adam Dr. Djuanda M Noor
Prof.Dr. Harsinen Sanusi Dr. Syamsu Rijal
Dr. Aryanti, Mkes, SpGK Dr. Rosdiana Iqbal, PhD
Dr. Suci, SpPK
Prof.DR.dr. Nur Puji A
Dr. Robert S
DR.Dr. Satriono
Dr. Ida Royani, MKes
Dr. Husaini, SpPD Dr. Junus Baan
Dr. Truly Dasril
Dr. Habibah SM
Dr. Indah Lestari, SpPD Dr. Himawan S
Dr. Haerani Rasyid , SpPD
Dr. Fabiola MS. Adam
Dr. Anna Sari Dewi ,SpOG

Dr. Erwin Rachman,SpS