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Suatu sel kanker yang memiliki sifat dan potensi yang sama
seperti stem cell / sel induk normal, namun setelah
mengalami mutasi dapat menghasilkan sel-sel kanker yang
terdiferensiasi dengan tidak terkontrol diberbagai jaringan
tubuh.
TUMORAL
SELF-RENEWAL
DIFFERENTIATION
PROLIFERATIVE ABILITY
ABERRANT REGULATION
Agen Karsinogenik
Skema dasar
molekular kanker
Subcellular Locations
Cell surface
Inner aspect of plasma
membrane
Gene
TGF- receptor
E-cadherin
NF1
Cytoskeleton
NF2
Cytosol
APC/-catenin
Nucleus
Function
Growth inhibition
Cell adhesion
Inhibition of RAS signal
transduction and of p21 cell
cycle inhibitor
Cytoskeletal stability
PTEN
Inhibition of signal
transduction
PI3 kinase signal transduction
RB1
p53
WT1
P16/INK4a
Nuclear transcription
Regulation of cell cycle by
inhibition of cyclindependent
kinases
DNA repair
KESIMPULAN
1. The stem cell, whether normal or cancer, and its niche
influence each other, which maintains their capabilities and
controls their fates.
2. Stem cell regulation and maintenance is not a simple
single-factor phenomenon and a large part of the complicated
molecular mechanism is yet to be elucidated.
3. Understanding the regulatory system could lead to
therapeutic approaches that directly target stem cells or
niches.
.
TERIMA KASIH