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KELAINAN PIGMENTASI

DR. ISMIRALDA OKE PUTRANTI, SPKK
DEP/KSM IK.KULIT DAN KELAMIN FK UNSOED/RSMS
2016

lichen sclerosus)  Post inflammatory 2 .White Lesion (Leucoderma)  Causes :  Lack of melanin pigment  due tue :  Decrease number of melanocytes (vitiligo)  Defect of melanogenesis  A localized vasoconstriction  Other mechanisms :  Special keratosis in warts and molluscum contagiosum  Tension exerted on the epidermis by the wall of cyst  Deposit of white substances (skin calcification)  Cutaneous sclerosisor hyalinization of collagen bundles (morphea.

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lengan kromosom 15q  disertai freckles  OCA 3  mutase gen TYRP1  Hermansky-Pudlak Syndrome  disertai fibrosis paru  Chediak-Highasi Syndrome  defek imunologi berat .ALBINISME ALBINISME  Resesif  Lesi hipopigmentasi generalisata  Etio : disfungsi komplemen normal melanosit  parsial/total hipopigmentasi (gangguan deferensiasi melanosit)  Tipe  OCA 1  krn hilangnya fungsi tirosinase akibat mutase gen TYR  total albinisme  OCA 2  mutasi gen OCA (P).

: defek pigmentasi pada iris dan rambut. poliosis . tuli kongenital dan defek kraniofasial  Piebaldisme : bercak hipopigmentasi pada ventral/lateral tubuh dan ekstremitas. Teitz Synd.KELAINAN PIGMENTASI GENETIK LAIN  Waardenburg Syndrome.

mixed)  Universalis  Lokalisata (segmental.VITILIGO  Penyakit autoimun. fokal. mukokutan) . akrofasial. genetik  Etio pasti belum jelas  kematian melanosit  Tipe vitiligo :  Generalisata (vulgaris.

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 Terapi : .

HIPERMELANOSITOSIS .

 Freckles and lentigenes. grey)  Hyperpigmentation / hypermelanoses  high melanin deposit (black. brown. brown >>) Causes :  Genetics :  Café-au-lait macules (Albright’s syndrome. Neurofibromatosis).Dark Lesions (Black. blue.  Mongolian spots 10 .

Acquired : Pigment deposition : metals (gold.silver). antibiotic (minocycline) Nutritional : pellagra. Vit B12 def Post inflammatory Sistemic diseases : haemochromatoses. phenothiazines. porphyria Reduction of peripheral oxygen  cyanosis . Melasma Medications : chemotherapeutics. tattoo Endocrine : Addison’s disease.

 Hypermelanocytoses  melanocytes >> (Blue. grey – ceruloderma)  Nevi of Ota / Nevi of Ito 12 .

 Jaundice : Bilirubin extracellulare fluids (intradermal. lipoprotein deposits (lipoproteinomas)  Exssesive carotenoid deposits in hypodermis and startum corneum  hypercarotenemia  Granulomatous/histolytic cell infiltrates. conjunctival membrane/other mucous membrane Hyperbilirubinemia 13 .Yellowish Skin (Xanthoderma)  Altering epidermis or dermis   Stratum corneum thickening  producing Yellowish keratosis  Alteration of connective tissue  elastic fibers (pseudoxanthoma elasticum). collagen bundles (collagenic hamartomas)  Abnomal deposit  lipid deposit (xanthomas. xanthelasma).

Selesai .