Bone Repair

Mishael V. Zoleta
 Repair of a fractured bone occurs
through several stages, but utilizes
mechanisms already in place for
bone remodeling.
 Blood vessels torn
within the fracture
release blood which
clots to produce a
large fracture
hematoma.
 This is gradually
removed by
macrophages and
replaced by a soft
fibrocartilage-like
mass of procallus
tissue rich in
collagen and
fibroblasts. If
broken, the
 This soft procallus is
invaded by regrowing
blood vessels and
osteoblasts. In the
next few weeks the
fibrocartilage is
gradually replaced by
trabeculae of primary
bone, forming a hard
callus throughout the
original area of
 The primary bone is
then remodeled as
compact and
cancellous bone in
continuity with the
adjacent uninjured
areas and fully
functional
vasculature is re-
established.