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Organizarea

sistemului imun

• Celule. Alcatuire • Organe limfoide. • Molecule .

Organele sistemului imun • organe limfoide primare • organe limfoide secundare .

Organele limfoide primare • Timusul. • Maduva osoasa hematogena .

Timusul • Structura – Zona corticala –cel. – Zona medulara – corpusculi Hassal • Functie – Selectie pozitiva – in corticala – Selectie negativa – in medulara . Doica.

Selectia celulelor T Corticala – selectia pozitiva Medulara – selectia negativa .

L.P pt limf B Sediul variabil cu virsta fat copil adult . Maduva osoasa hematogena Al II-lea organ limfoid primar Functie dubla: hematopoeza O.

Organ Bursal Hieronymus Fabricus ab Aquapendende Bursa lui Fabricius (1533–1619) .

lymphnodes T lymphocyte lineage Thymus T lymphocyte . B lymphocyte Bursa of fabricus (birds) B lymphocyte lineage Bone marrow (mammals) Blood Blood.

Stadiile de dezvoltare – Limfocit B .

Organele limfoide secundare Ganglionii limfatici Splina .

Ganglionii limfatici •Aglomerari celulare •Capsula fibroasa + parenchim •Parenchim  corticala  paracorticala  medulara •RIU •RIC .

Splina • Pulpa rosie/pulpa alba • Pulpa alba – Zona marginata (Mc) – PALS intern (B) – PALS extern (T) • RIU • RIC .