Neutrophils

Members
Chin Dejkajohnwud 5961058
Warith AL Prat 5961130
Mark Chankrabee 5961081
Phuchit Bunluesak 5961038
Suparada Suwanlertlum 5961084

White blood cells are
the cells of the immune
system that are involved in
protecting the body
against both infectious
disease and foreign
invaders.

Function
Granulocytes
Neutrophil-Phagocytize bacteria
Eosinophil-Kill parasitic worms; complex role in allergy and asthma
Basophil-release histamine and other mediators of inflammation;contain
heparin, and anticoagulant
Agranulocytes
Lymphocyte-mount immune response by direct cell attack or via antibodies
Monocyte-phagocytosis; develop into macrophages in the tissue

Neutrophil
Neutrophils is a type of white blood cells,
that help that immune system.

They goes around our body, bloodstream.

for about 3-12 hours, then they will move
to different tissues.

The Neutrophils sense the bacteria by the

chemical that the bacteria release and go
to eat and digest it.

Locations

Neutrophils are form in the bone

marrow.
Neutrophils can be found on
large or small blood vessels.
They only live for 2-3 days.
Neutrophil Feature (General)
Plasma membrane
In the cytoplasm
Golgi apparatus
mitochondria
No Rough endoplasmic reticulum
ribosome
Nucleus(nuclear pore)
Was created by bone marrow
And then after they find and destroy the invader, they breakup
into small pieces that can be eaten by other cell.

Specialized Organelles
These are some specialized organelles in the Neutrophils

Lysosome Granule Cytoskeleton

Glycogen Phagosome

Lysosome
Purpose = digest the bacteria
Also digest or get rid of the nonfunctional
organelles
Break down food vacuoles that enter cell

Macromolecule Small molecule


Granule
Three types of granules are present in neutrophils:
Primary granules are azurophilic, supply enzymes for
digestive and bactericidal functions. It become violet
color.

Secondary granules (specific) are the most

numerous type and contain complement
activators and enzymes. It become pink color.

Finally tertiary granules are either

phosphatases or metalloproteinases with the
later aiding movement through connective
tissue.

Glycogen

Neutrophil contained large amount of Function:

glycogen Break down carbohydrates glucose (sugar)
Glycogen Neutrophil with energy Many connected of glucose made up Glycogen
Phagosome

Is a vacuole that was in a cytoplasm of
Neutrophils.

It was used to kill and digest bacteria,

fungi, virus, etc.

Cytoskeleton
Function: movement of the cell Have a complex structure

Make up from protein actin, actin

binding, tubulin protein and etc.
 Neutrophil development
Myeloblast stage
occurs in the bone marrow

The first stage of neutrophil development

has a large nucleus

small amount of cytoplasm

which does not contain granules

chromatin in the nucleus is not condensed.

 Neutrophil development
Promyelocyte stage
Still in bone marrow

larger than the myeloblast

nucleus is round or oval

the nuclear chromatin is not condensed

primary granules are present in cytoplasm

***The primary granules bud off the concave surface of the Golgi
complex
 Neutrophil development

Myelocyte stage
nucleus at this stage is round or oval
the chromatin is coarse
the secondary granules develop
takes place in the bone marrow

***Secondary granules arise from the convex surface of the Golgi

complex
 Neutrophil development
Metamyelocyte stage

present in the blood

cytoplasm is filled with primary,

secondary and tertiary granules

nucleus start to break up

the cytoplasm is stained pink and

contains numerous granules

The shape of the nucleus is

kidney-bean or a bent rod
 Neutrophil development

Polymorphonuclear stage

the final stage

nucleus is sausage-shaped

in the bloodstream and tissue

the color of cytoplasm become pink

because of the amount of granules
the chromatin condense even more
 Neutrophil Function

Neutrophil located in Process of Phagocytize

Sensing pathogen from the
blood vessels chemical released from the
Phagocyte cell bacteria by protein on it surface.
The first cell going to Engulf (eat) the bacteria
Trap the bacteria inside
invader phagosome
Main function: Fused with lysosome inside
Protect body the neutrophil
Killing bacteria Destroy bacteria
The neutrophil was use out
(Phagocytize)
Phagocytize
https://www.youtube.com/watch?
v=0TvTyj5FAaQ
 Shape of Neutrophil

Multilobed Flexible Shape Small Shape

make them visually easy to eat bacteria help it to quickly and
distinctive from and body protection easier to enter the
lymphocytes having tissue
easily to know where
round nucleus
the bacteria are
 Lobes or Lobular nucleic

Made of chromatin and the

DNA of certain immune cells
Can move freely and flexibility

Have 2-5 lobes because of

chromatin change during
activation steps
LOBES
How does the function of neutrophil keep the
organism alive?
Function: protect body & kill bacteria (like police)

Without neutrophil:
Lack of protection in
body
Organelles become
nonfunctional
Organism died
 Neutrophilia:
is an increase in circulating neutrophils in
the non marginal pool, which constitutes 4-
5% of total body neutrophil stores.
Cause of neutrophilia &
neutropenia :
Acute and chronic bacterial
infection, especially pyogenic
bacteria.
Some viral infections (chickenpox,
herpes simplex).
Some fungal infections.
Treatments:
Antibiotics for bacterial infections
Changing medications, in cases of
drug-induced neutropenia
Granulocytic (White blood cell
transfusion)
Stem cell transplants
Neutropenia:
is a decrease in circulating neutrophils in
the non marginal pool, which constitutes 4-
5% of total body neutrophil stores.
Cause of neutropenia :
Low-grade fever
Sore mouth
Pain and swelling
Skin abscesses
Symptoms of pneumonia
(eg. cough, dyspnea)
Perirectal pain and irritation
Treatments:
Take Antibiotics
See hematologist
Blood Test
Maintain a healthy lifestyle
References :
1. Overall

-Monocytes. (n.d.). Retrieved January 26, 2017, from

http://study.com/academy/lesson/what-are-monocytes-definition-function-blood-test.html
-Lymphocytes. (n.d.). Retrieved January 26, 2017, from
http://study.com/academy/lesson/lymphocytes-definition-functions-types.html
-Basophils. (n.d.). Retrieved January 26, 2017, from
http://study.com/academy/lesson/basophils-definition-function.html

2. Function
Rader, A. (1997). Lysosome. Retrieved January 27, 2017, from
http://www.biology4kids.com/files/cell_lysosome.html
Jl, G. (1986, May). Neutrophil granules. Retrieved January 27, 2017, from
https://www.ncbi.nlm.nih.gov/pubmed/3009589
Glycogen. (n.d.). Retrieved January 12, 2017, from
http://kidshealth.org/LAWW/en/teens/glycogen.html?WT.ac=ctg
References :
3. Neutrophils
Neutrophils. (n.d.). Retrieved January 10, 2017, from
http://study.com/academy/lesson/neutrophils-definition-function-quiz.html

4. Neutrophils function
Metzler, K. (n.d.). Neutrophils: Definition & Function. Retrieved January 26, 2017, from
http://study.com/academy/lesson/neutrophils-definition-function-quiz.html
M. (Ed.). (n.d.). Neutrophil Granulocyte. Retrieved January 26, 2017, from
http://www.medfriendly.com/neutrophil-neutropenia.html
C. (Ed.). (2012, January 23). How White Blood Cells Work. Retrieved January 26, 2017, from
https://www.youtube.com/watch?v=0TvTyj5FAaQ
ST.JOHN, D. M. (2016, December 04). Which White Blood Cells Are Phagocytes? Retrieved January
26, 2017, from http://www.livestrong.com/article/129286-white-blood-cells-phagocytes/
Phagocytosis. (2010, July). Retrieved January 27, 2017, from
https://courses.washington.edu/conj/bloodcells/phagocytosis.html
References :
5. Locations
Location of Neutrophil. (n.d.). Retrieved January 10, 2017, from
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0022058/

https://www.youtube.com/watch?v=0TvTyj5FAaQ

6. Specialized Organelles
Rader, A. (1997). Lysosome. Retrieved January 27, 2017, from
http://www.biology4kids.com/files/cell_lysosome.html
Jl, G. (1986, May). Neutrophil granules. Retrieved January 27, 2017, from
https://www.ncbi.nlm.nih.gov/pubmed/3009589
Glycogen. (n.d.). Retrieved January 12, 2017, from
http://kidshealth.org/LAWW/en/teens/glycogen.html?WT.ac=ctg
References :
7. Development

https://en.wikipedia.org/wiki/Neutrophil#cite_note-ZFneu-11
W. (2017, January 6). Neutrophil. Retrieved January 26, 2017, from
https://en.wikipedia.org/wiki/Neutrophil#cite_note-ZFneu-11
http://www.wellness.com/reference/allergies/neutrophil
W. (n.d.). Neutrophil. Retrieved January 26, 2017, from
http://www.wellness.com/reference/allergies/neutrophil
http://www.uwosh.edu/med_tech/what-is-elementary-hematology/white-blood-cells
Oshkosh, W. (2014, May 20). The Five Common White Blood Cells. Retrieved January 26,
2017, from http://www.uwosh.edu/med_tech/what-is-elementary-hematology/white-blood-cells
http://study.com/academy/lesson/neutrophils-definition-function-quiz.html
Metzler, K. (n.d.). Neutrophils: Definition & Function. Retrieved January 26, 2017, from
http://study.com/academy/lesson/neutrophils-definition-function-quiz.html
References :
8. Shape
(2011, May 18). Retrieved January 27, 2017, from
https://allaboutblood.com/2011/05/18/neutrophil-segmentation-and-projections/
9. Lobes
(2011, May 18). Retrieved January 27, 2017, from
https://allaboutblood.com/2011/05/18/neutrophil-segmentation-and-projections/

10. Treatments
A., Baluch. (2007, July 6). Causes of neutrophilia, neutropenia, and treatment.
Retrieved January 26, 2017, from http://www.gponline.com/causes-neutrophilia-
treatment/haematology/leukaemia/article/668537