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A Controversial

ASPARTAME Sweetener
Presentation by: Megan L
Martin and Thomas Goeke
PRODUCTION OF
ASPARTAME
Made in a lab setting by coupling together L-phenylalanine and L-
aspartic acid
Aspartame can be made both chemically and enzymatically
Most often is produced in an enzymatic process, because the end
product does not need to be purified and separated. The only
substance produced is the sweetener, alpha-aspartame.
The chemical process produces alpha-aspartame as well as the
waste product beta-aspartame. This then needs to be purified and
separated through other chemical processes.
COMMON USES OF
ASPARTAME
Most widely used as a artificial sweetener
Is used in over 6,000 products
Some examples include
Tabletop Sweeteners
Chewing Gum
Breakfast Cereal
Soft Drinks (Most often Diet, or Colorful Flavored Sodas)
Powdered Drinks

Also used in other applications
Can be found in Children’s Medicine
Used as a Flavor Enhancer and Preservative
Used in various Cosmetic Products
ABSORPTION AND CHEMICAL
BREAKDOWN
Upon Digestion, broken down into three main chemical
compounds
Aspartic Acid
Phenylalanine
Methanol

All are found and consumed from other common foods
Are absorbed through the small intestine and then enter blood
stream
No studies indicate receiving these compounds from aspartame
has different effects than other natural sources
NUTRITIONAL POSITIVES
No outright benefits
Have been found useful in treating and creating foods for various
diseases
Diabetes
Reactive Hyperglycemia

Has been a valuable alternative in fighting obesity and highly
caloric diets
Much cheaper to produce and use (in comparison to other non-
nutritive sweeteners
SCIENTIFICALLY PROVEN
HAZARDS
Many claims have been made regarding negative effects –
Including..
Carcinogen
Mood Effects
Enhanced Susceptibility to Seizures
Higher Frequency of Migraines
Decreased Cognitive Function
However SOME Caution is Advised

Not many have been definitively proven
Nothing Generated to Change FDA status of Aspartame
SCIENTIFICALLY PROVEN
HAZARDS
Proven Effects – Include…
Allergic Reaction
Increase in Irritability
Phenylalanine Poisoning in individuals with
“phenylketonuria”
CONCLUSION
Based on Scientific Research there is no significant reasons to be
found stating that Aspartame is harmful.
Some doubts still exist, however, there are practical uses of
Aspartame
It is the consumers personal choice
However still in many people’s opinion a viable low-calorie sugar
substitute
REFERENCES
Aspartame study findings published. (2015). Food &  Soffritti, M., Padovani, M., Tibaldi, E.,
Drink Technology, 14(7), 8. Falcioni, L.,
Lindseth, G. N., Coolahan, S. E., Petros, T. V., &
Manservisi, F., & Belpoggi, F. (2014). The
Lindseth, P. D. (2014). Neurobehavioral Effects of
Aspartame Consumption. Research In Nursing & carcinogenic effects of aspartame: The
Health, 37(3), 1851939p.doi:10.1002/nur.21595 urgent
National Center for Biotechnology Information. need for regulatory re-evaluation.
PubChem Compound Database; CID=134601, American
<https://pubchem.ncbi.nlm.nih.gov/compound
Journal Of Industrial Medicine, 57(4),
/134601>(accessed Oct. 22, 2015).
 Saravis, S., Schachar, R., Zlotkin, S., Leiter, L.A., &
383-397.
Anderson, G. H. (1990). Aspartame: Effects on doi:10.1002/ajim.22296
Learning, Behavior, and Mood. Pediatrics, 86(1),  Tandel, K. R. (2011). Sugar substitutes:
75. Health
controversy over perceived benefits.
Journal Of
ANY QUESTIONS?