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Ilham Hidayat RT Maha

Definisi
Diabetes Melitus merupakan kelompok
kelainan heterogen yang ditandai oleh
kenaikan kadar glukosa dalam darah atau
hiperglikemia
ETILOGI dan Patogenesis
Genetik
Virus Hepatitis B
Penyakit Pankreas
Gaya Hidup
Kelainan Hormon
Jenis-jenis DM
DM TIPE 1 (IDDM) : autoimun, idiopatik
DM TIPE 2 (NIDDM) : resistensi insulin
GESTASIONAL
JUVENIL/SENILIS
Penurunan Sensitivitas
Insulin Resistensi insulin, penurunan
kemampuan insulin dalam
bekerja di jaringan target
secara efektif, merupakan
suatu fitur khas dari diabetes
mellitus tipe dua yang
diakibatkan oleh kombinasi
genetik dengan obesitas.
Obesitas
Obesitas yang menyebabkan diabetes
mellitus tipe 2, baik obesitas viseral maupun
obesitas sentral, diduga sebagai bagian dari
proses patogenik. Peningkatan masa adiposit
menyebabkan peningkatan asam lemak bebas
yang bersirkulasi dan produk lemak lainnya.
Sebagai contoh, adiposit melepaskan
berbagai produk biologis (asam lemak non
esterifikasi, protein terkat retinol 4, leptin,
TNF-alfa, resistin, dan adiponectin).
Patofisiologi Sistem lain
Referensi
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Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P.:Expert Committee on the
Diagnosis and Classification of Diabetes Mellitus2, the Expert Committee on the Diagnosis and Classification of
Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus.Diabetes Care2003;26: 3160 3167[
PubMed ]
3.International Expert CommitteeInternational Expert Committee report on the role of the A1C assay in the
diagnosis of diabetes.Diabetes Care2009;32: 1327 1334[PMC free article][PubMed]
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Gen Intern Med2004;19: 1175 1180[PMC free article][PubMed]
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nondiabetic women.Am J Med2007;120: 720 727[PMC free article][PubMed]
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glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study.Diabetes
Care2009;32: 644 646
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Research2007;149: 196 204=
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Walker EA, Nathan DM.:Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes
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Caces E, Tichet J, Charles MA, Eschwege E.: the DESIR Study GroupUse of HbA 1cin predicting progression to diabetes
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