Autoregulasi renal & pengaruh

hormon
Autoregulasi mempertahankan LGF ttp konstan pd
tek darah arteri 80-180 mmHg
Umpan balik tubuloglomerulus
 Regulation of
Glomerular
Filtration Rate

Auto- Neural Hormonal

regulation regulation Regulation
Myogenic Tubuloglomerular Angiotensin II ADH ANP
respons feedback
 Regulation of Glomerular Filtration Rate
Renal Auto-regulation
Regulation Major Mechanism Effect on GFR
Stimulus
Myogenic Stretching of Contraction of Decrease GFR
afferent smooth by constricting
arteriole walls muscles in the lumen
due to afferent
increased arteriole wall
systematic BP
Decline in Dilation of AA Increases GFR
glomerular and G.
blood pressure capillaries
Constriction of
EA
 Regulation of Glomerular Filtration Rate
Renal Auto-regulation

Regulation Major Mechanism Effect on

Stimulus GFR
Tubuloglomerular Rapid increase Decreased Decrease
feedback in Na+ and Cl- release of GFR and
In lumen at Nitric Oxide filtrate
the macula by JGA volume
densa due to causing AA
increased BP constriction
 Regulation of Glomerular Filtration Rate
Neural Regulation

Regulation Major Mechanism Effect on GFR

Stimulus

Sympathetic Acute fall in Constriction of Decrease GFR

Nerves systematic afferent and filtrate
(Autonomic) blood pressure. arterioles volume to
Release of maintain blood
norepinephrine volume
 Regulation of Glomerular Filtration Rate
Hormonal Regulation

Regulation Major Stimulus Mechanism Effect on GFR

Angiotensin II Decreased Constriction of Decreases GFR

blood volume both afferent
or decreased and efferent
blood pressure arterioles

Atrial Stretching of Relaxation of Increases GFR

natriuretic the arterial the mesangial
peptide walls due to cells increasing
increased blood filtration
volume surface
 Regulation of Glomerular Filtration Rate
Hormonal Regulation
Regulation Major Mechanism Effect on
Stimulus GFR
Antidiuretic Increased Stimulate Increases
hormone Angiotensin II insertion of blood
ADH or decreased aquaporin-2 volume to
volume of (water channels) return GFR
extracellular In apical to normal
fluid membrane or
principal cells
Aldosterone Secreted from Increases Increases
adrenal cortex reabsorption of blood
because of Na+ and water by volume to
increased principal cells of return GFR
Angiotensin II the DCT to normal
levels collecting duct
REGULATION OF WATER INTAKE AND
OUTPUT
Peran hormon
 Hormonal regulation
Angiotensin II
Stimulates arteriole
vasoconstriction
throughout body
Less so in afferent
arterioles
Stimulates aldosterone
secretion
Stimulates Na+
reabsorption
Stimulates ADH release
Renin-Angiotension-Aldosterone System
Pengaturan saraf simpatis pada GFR