Pathogenesis of Measles

By: Rey Martino (for educational use only)

Paramyxovirus
‡ spherical, nonsegmented, singlestranded RNA virus in the Morbillivirus family contains six structural proteins, three that are complexed to the RNA and three that are associated with the viral membrane envelope Two of the membrane envelope proteins are important in its pathogenesis The F (fusion) protein is responsible for fusion of virus and host cell membranes, viral penetration and hemolysis The H (hemagglutinin) protein is responsible for adsorption of the virus to cells. ‡

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‡ The virions enter the cell by binding to the human cellular receptor CD46, fusing with the membrane, and releasing the nucleocapsid into the cytoplasm. ‡ The viral replication takes approximately 24 hours, then the infectious viral particles bud off from the cell membrane

Pathogenesis of Measles (general)
Infected nfected People
Nasal/throat secretion, airborne transmission

Healthy People

inhaled

Attach to primary site : Respiratory epithelium of the nasopharynx
2-3 days later multiply, replication, invasion to regional lymph nodes

MV Replicates in lymphoid tissues (spleen, thymus, lymph nodes

Skin, viscera, kidney, bladder

Second Viremia

5-7 days after initial infection

Primary Viremia + subsequent infection of R-E system

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