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Dormita

(Melatonin)

Melatonin and Sleep Latency


Dormita
Sleep Quality (Melatonin)

Sleep quality is defined as ones satisfaction of the sleep


experience, integrating aspects of sleep initiation, sleep
maintenance, sleep quantity, and refreshment upon
awakening.
For someone with problems initiating sleep, the sleep onset
period may be the strongest determinant of sleep quality.
Dormita
Good Sleep Quality (Melatonin)

Good sleep quality is associated with a wide range of


positive outcomes such as:
Better health
Less daytime sleepiness
Greater wellbeing
Better psychological functioning

The Subjective Meaning of Sleep Quality: A Comparison of Individuals with


and without Insomnia; SLEEP 2008;31(3):383-393.
Dormita
Sleep Latency* (Melatonin)

This is the duration of time between when the lights


are turned off as the patient attempts to sleep, until
the time patient actually falls asleep, as evidenced
by EEG and behavioral parameters changes
consistent with sleep.

*aka, sleep onset latency

The Subjective Meaning of Sleep Quality: A Comparison of Individuals with


and without Insomnia; SLEEP 2008;31(3):383-393.
Dormita
Melatonin (Melatonin)

Melatonin is the natural hormone the body secretes that


helps to maintain the wake-sleep cycle (also called biological
clock). The wake-sleep cycle is the process of sleep and
wakefulness; in humans this averages 8 hours of nighttime
sleep and 16 hours of daytime activity.
Melatonin is also made synthetically
and available without a prescription
as an over-the-counter (OTC) dietary
supplement in the U.S. and other
countries.

https://www.drugs.com/melatonin.html [Cited: 1-Jun-17]


Dormita
Melatonin Synthesis: Pineal Gland (Melatonin)

In vertebrates, the pineal


gland synthesizes melatonin in
a circadian fashion, with
nighttime darkness being a
requirement for maximal
production; because of this,
melatonin is referred to as the
chemical expression of
darkness.

Melatonin: Exceeding Expectations


Russel J. Reiter, Dun Xian Tan, Annia Galano
Physiology Published 1 September 2014 Vol. 29 no. 5, 325-
333 DOI: 10.1152/physiol.00011.2014
Dormita
Melatonin Synthesis: Pineal Gland (Melatonin)

Fig. Schematic presentation of the


stimulation (darkness) and
inhibition (light) of melatonin
secretion from pineal gland
involving the neural pathway
originating in retina and passing
through suprachiasmatic nucleus
(SCN), the main circadian
oscillator in the brain, to reach
pinealocytes via adrenergic nerves
and adrenergic receptors at the
cell membrane. The structure of
melatonin secreted by pineal
gland.

S. J. KONTUREK1, P. C. KONTUREK2, T. BRZOZOWSKI1, G. A. BUBENIK3


ROLE OF MELATONIN IN UPPER GASTROINTESTINAL TRACT
Dormita
Melatonin and Sleep (Melatonin)

Numerous laboratory studies under stringent


conditions clearly demonstrate that
administration of melatonin acutely affects
sleep in humans*.

*Melatonin also affects thermoregulation


Journal of Neuroendocrinology, 2003, Vol. 15, 432437
Dormita
Effects of Exogenous Melatonin (Melatonin)

Exogenous melatonin exerts effects on the


main characteristics of human sleep (i.e. slow
waves, sleep spindles, sleep latency and sleep
consolidation).

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Dormita
Effects of Exogenous Melatonin (Melatonin)

Exogenous melatonin elicits all the physiological effects which


occur in the evening during endogenous melatonin secretion.
Exogenous melatonin elicits time-dependent soporific effects
(sleep inducing), which have been corroborated with
electrophysiological measures of sleepiness such as
electroencephalographic theta activity during wakefulness.

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Dormita
Fig. Relationship of Plasma Melatonin & Sleep
(Melatonin)
Phase relationships between the circadian
rhythms of plasma melatonin and sleep
consolidation.

Decrease in wake episodes

The daily circadian increase in


melatonin secretion coincides
with a decrease in wake episodes
Increase in plasma melatonin
during scheduled sleep episodes.
Dormita
Melatonin: Soporific effect & thermoregulation
(Melatonin)

The soporific effect (Sleep inducing) is


paralleled by a time and dose dependent
hypothermic action, mediated by an increase
in heat loss.

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Dormita
Clinical analysis (Melatonin)

In an experiment where when blocking this natural evening


increase in heat loss, subjective sleepiness, and melatonin
secretion by light exposure, it showed that:

Melatonin replacement acutely recovered the


evening increase in heat loss, subjective sleepiness
and also theta activity in the waking EEG.

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Clinical Analysis: Dormita
Melatonin and sleep propensity (Melatonin)

This suggested a causal relationship between


melatonin and sleepiness, probably mediated by
thermoregulatory mechanisms.
The onset of melatonin secretion might contribute to
the rise in sleepiness and sleep propensity that occurs
in the evening.

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Dormita
Melatonin & EEG activity (Melatonin)

Quantitative analysis of the sleep EEG revealed that


melatonin*, given shortly before a daytime sleep
episode, suppresses low EEG components and
increases EEG activity in the sleep-spindle
frequency range.

Similar changes in the sleep EEG spectra occur in sleep during the
melatonin secretory phase (biological night) when compared with sleep
occurring outside the melatonin secretory phase (biological day).

*Melatonin 5mg dose


Journal of Neuroendocrinology, 2003, Vol. 15, 432437
Dormita
Short Sleep latency (Melatonin)

The most consistent effect found in the


studies was that sleep latency was shorter
after melatonin, even at rather low doses.

Journal of Neuroendocrinology, 2003, Vol. 15, 432437


Meta-analysis 1: Effect of exogenous melatonin Dormita
on sleep (1996-2003) (Melatonin)
17 clinical studies (284 subjects)
Aim: The effect of melatonin on sleep was demonstrated.
Outcome measures: Sleep onset latency, total sleep duration, and sleep efficiency.
Effect Size: The difference between the response on placebo and the mean response on melatonin for
each outcome was measured.
Results:
On Melatonin treatment:
All patients:
Reduced sleep onset latency by 4.0 min (95% CI 2.5, 5.4);
Increased sleep efficiency by 2.2% (95% CI 0.2, 4.2),
Increased total sleep duration by 12.8 min (95% CI 2.9, 22.8).
In people with no relevant medical condition other than
insomnia:
Reduced sleep onset latency 3.9 min (95% CI (2.5, 5.4));
sleep efficiency increased to 3.1% (95% CI (0.7, 5.5));
sleep duration increased to 13.7 min (95% CI (3.1, 24.3)).

Effects of exogenous melatonin on sleep: a meta-analysis Brzezinski, Amnon et al. Sleep


(2005)Medicine Reviews , Volume 9 , Issue 1 , 41 - 50
Meta-analysis 1: Effect of exogenous melatonin Dormita
on sleep (1996-2003) (Melatonin)

Effects of exogenous melatonin on sleep: a meta-analysis Brzezinski, Amnon et al. Sleep


(2005)Medicine Reviews , Volume 9 , Issue 1 , 41 - 50
Meta-Analysis 2: Melatonin for the Treatment of Primary Dormita
Sleep Disorders (2001-2010) (Melatonin)

Nineteen studies involving 1683 subjects


Overall sleep quality was significantly improved in subjects
taking melatonin compared to placebo.

Efficacy parameters weighted mean CI; p value


difference (WMD)
Reduction of Sleep 7.06 minutes 95%; <0.001
Latency
Increase in total 8.25 minutes 95%; 0.013
sleep time

This meta-analysis demonstrates that melatonin decreases sleep


onset latency, increases total sleep time and improves overall
sleep quality. The effects of melatonin on sleep are modest but do
not appear to dissipate with continued melatonin use.
Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-Analysis: Melatonin for the
Treatment of Primary Sleep Disorders. PLoS ONE, 8(5), e63773.
http://doi.org/10.1371/journal.pone.0063773
Meta-Analysis 2: Melatonin for the Treatment of Primary Dormita
Sleep Disorders (2001-2010) (Melatonin)
FIG. EFFICACY OF MELATONIN IN SLEEP LATENCY

Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-Analysis: Melatonin for the
Treatment of Primary Sleep Disorders. PLoS ONE, 8(5), e63773.
http://doi.org/10.1371/journal.pone.0063773
Dormita
Dormita Description (Melatonin)

Dormita is a food supplement that contains


active Melatonin

Ingredients:
Hop cone Extract 31.25mg
Lemon Balm leaf Extract 150mg
Melatonin 1mg

Prescribing information Dormita 2017


Dormita
Hop Cone Extract (Melatonin)

Hop cones have long been used for medicinal


purposes. In particular, hop preparations were
mainly recommended for the treatment of
sleeping disorders.

Platelets. 2011;22(5):345-52. doi: 10.3109/09537104.2010.549597.


Epub 2011 Feb 25.
Dormita
Lemon Balm Leaf (Melatonin)

Lemon balm (Melissa officinalis), a member of the


mint family, is considered a calming herb. It was used
as far back as the Middle Ages to reduce stress and
anxiety, promote sleep and other uses*.
Melissa officinalis L. has been shown as an anti-
stress and anxiolytic agent.

*improve appetite, and ease pain and discomfort from indigestion (including
gas and bloating, as well as colic

Cases, Julien et al. Pilot Trial of Melissa Officinalis L. Leaf Extract in the Treatment of Volunteers Suffering from Mild-to-Moderate Anxiety Disorders
and Sleep Disturbances. Mediterranean Journal of Nutrition and Metabolism 4.3 (2011): 211218. PMC. Web. 1 June 2017.
http://www.umm.edu/health/medical/altmed/herb/lemon-balm
Dormita
Use & Instructions (Melatonin)

Dormita contributes to the reduction of time


taken to fall asleep.

Adults: 1 tablet 2 hours before sleeping.


Swallow tablet with a glass of water.

Prescribing information Dormita 2017


Dormita
Contraindications (Melatonin)

Never take Dormita if you have allergy to any


of its ingredients.

Prescribing information Dormita 2017


Dormita
Warning & Precautions (Melatonin)

Do not exceed stated dose


Supplements are not substitute for balanced diet
Unsuitable for children, teenagers, pregnancy and breastfeeding women
Should not be used during pregnancy and breast feeding
If pregnancy occurs during its use, discuss with your doctor regarding
continuing treatment
Do not drive or operate machinery after use

Prescribing information Dormita 2017


Drugs.com/melatonin
Dormita
(Melatonin)
Dormita
(Melatonin)

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