Sebaceous adenoma

Deba P Sarma, MD
Omaha
F 65, right lower eyelid
 Sebaceous adenoma
Benign cutaneous adnexal neoplasm arising from
sebaceous glands.
Local recurrenc may occur due incomplete removal.

When multiple sebaceous adenomas are associated with

Muir-Torre syndrome, visceral cancers, such as
adenocarcinoma of the colon, stomach, duodenum,
hematologic maignancy, genitourinary tract or
endometrium cancer may be present.

One significant feature of Muir-Torre syndrome is the

favorable prognosis of the associated cancers.
On immunostain, a loss of nuclear staining for MLH-1 or
MSH-2 is highly suggestive of the syndrome.

Sex: M=F, Age: After 50yrs.

Microscopic:
Tumor is multilobulated with frequent connection to the epidermis,
may be ulcerated.
Sharply demarcated from the surrounding tissue.
Proliferation of sebaceous lobules consisting of central, larger, mature
sebaceous cells with clear, bubbly cytoplasm (sebocytes), peripheral,
smaller, basaloid cells and transitional cells.

Sebocytes contain pale-staining, foamy-to-bubbly cytoplasm, and

central hyperchromatic nuclei.
Smaller basaloid cells contain round vesicular nuclei and basophilic
cytoplasm.
Transitional cells show eosinophilic cytoplasm.
Nuclear hyperchromatism, prominent nucleoli and abnormal mitotic
activity are rare.

Ratio between the sebocytes and basaloid cells is about 50% in

sebaceous adenoma.
If the tumor shows >50% basaloid cells, it is called sebaceous
epithelioma.