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By: Bruce J. Tromberg, Albert E.

(University of California Irvine)
Brian W. Poguea and Keith D. Paulsen
(Dartmouth College)
Arjun G. Yodh (University of Pennsylvania)
David A. Boas (Harvard Medical School)

Published: 2008
• About the researchers - NTROI
• Motivation
• Theoretical background
• Reviewed systems
• Conclusions and summary
• Multi-institutional Network for Translational Research in Optical
• Funded by the national cancer institute to advance Optical
imaging for cancer detection
• The most popular detection methods for breast cancer
are Xray mammogram, and ultrasound tests.
• Adding a DOS to the detection process will have
added value at a small price.
• Can detect tumors in radio-dense breast (with low fat
• Effective even for complex breast tissue due to past surgeries.
• Quick – less then 30 min.
• Uses Near Infrared frequencies (650-1100 nm).
• Measures absorption and scattering
• Allows to detect water, fat and Hemoglobin (oxidized and non
• The commonly used wavelengths are: 660, 685, 786, 809, 822,
852, 911, 946, and 973 nm. While the lower wavelengths
were chosen to measure hemoglobin and the 973 was selected
to target water, the 911 proved to be very sensitive to lipids.
Create a pulse with near infrared wavelengths and measure the returned light.
By measuring the returned power we can find the blood ingredients concentrations
(by finding the scattering coefficient and the absorption coefficient)
• Detection is made by using contrast function:
ct𝐻𝐻𝑏⋅ct𝐻2 𝑂
• Tissue optical index =
𝑓𝑎𝑡 𝑝𝑒𝑟𝑠𝑒𝑛𝑡𝑎𝑔𝑒

• The parameters were derived by measurements of 58 women

with breast cancer
• The probe being moved in 1 cm increments, to allow
measurement of the on-tumor and off-tumor values of the tissue
optical index TOI.
• the procedure to take measurements across the tumor region
and the contralateral breast
• monitoring of neoadjuvant chemotherapy response
• The changes are specific from the first days of the treatment
• 30% of the women will not respond with the treatment and will
need to be detected.
• Low cost
• Most tumors that are treated with neoadjuvant chemotherapy
are close to skin and therefore ideal for surface scanning
• Contains a large array of sources and detectors. By sending
multiple wavelength and the large number of measurements a
3d picture can be created for the different blood materials
• Gives extra information regarding malignancy status and
determine if biopsy is needed
• Helps discover tumors with high hemoglobin signature
• Improves the Receiver operating characteristic (ROC) of the