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FLAVONOID

NATURAL PRODUCTS CHEMISTRY


Introduction
Flavanoids merupakan suatu senyawa fenolik alam,
dimana ditemukan dalam dua bentuk yaitu dalam
bentuk bebas dan glykosida.
Flavonoids are widely distributed in nature and are especially
common in higher plants belonging families Leguminoseae, Rutacee,
Primulaceae, Polygonaceae, Salicaceaem Pinaceae, Rosaceae,
Asteraceae, Lamiaceae, Bignoniaceae, Moraceae, Betulaceae,
Rubiaceae, and Mytaceae.

Flavonoids are found to occur in different parts of the plants


( roots, bark, heartwood, leaves, flowers, fruits and seeds).
Sterokimia Flavonoid

Isoflavonoids
Flavonoid (3-benzopyrans)
(2-phenylbenzopyrans) neoflavonoids
(4-benzopyrans)
Flavonoid
Phenylbenzopyrans (C6-C3-C6 Backbone)
Isoflavon
Neoflavon

Minor flavon
Anthocyanins

Basically anthocyanins are 3,5,7-thihydroxy flacylium salts and


are classified based on the substitution pattern in the B ring of
the molecule. Generally 3-hydroxy and
5-hydroxy positions are glycosylated.

R4 R4
R4
R5 R3 O R5
R5
R3 O R6
+ R6
R3 O R2
R6
R1 O
R1
R9 R7
R1
R2 O
R2 - R8
Cl
Derivatives of flavones Derivatives of isoflavones
Anthocyanidin including glycosides including glycosides
R1=R2=R3=R4=R5=R6 R1=R2=R3=R4=R5=R6 R1=R2=R3=R4=R5=R6=R7=R8=R9
=H,OH or OMe or =H,OH or OMe or Alkylor =H,OH or OMe or Alkylor
glycoside/ Anthocyanin glycoside/ glycoside glycoside/ glycoside
BIOSINTESIS
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Constructed from the products of two different pathways


And catalyzed by CHALCONE SYNTHASE
Fungsi flavonoid

 Bergabung dengan senyawa lain membentuk zat


warna bunga------penyerbukan
 Allelopathy – herbivory defense, pathogen defense
 Menghambat radiasi UV yang merusak asam
nukleat
Radiasi UV-Efek Rumah Kaca- Pemanasan Global
Efek rumah kaca

GLOBAL
WARMING