Professional Documents
Culture Documents
Andree Kurniawan
Learning objectives
• SIRS
• Sepsis the presence (probable or documented) of infection
together with systemic manifestations of infection
• Severe sepsis Sepsis + sepsis-induced organ dysfunction or
tissue hypo-perfusion
• Sepsis shock Sepsis + shock
Causes
• Bacteria
– Gram negative
– Gram positive
• Fungal
• Virus
Risk
• Elderly population
• Child
• Neutropenia
• Immunocompromised (primary or secondary) patients
• Blood stream infections
• Chronic illness (diabetes, CKD, liver cirrhosis, cancer patients)
Signs and Symptoms
• Depend on
– Patient’s history,
– drug intolerances,
– recent antibiotic last 3 months,
– underlying disease, clinical syndrome,
– susceptibility patterns of pathogens,
– previous documented colonize or infection
• Virulence and growing resistant bacteria
• Empirical antifungal therapy (echinocandin, triazoles or
amphotericin B) candida score
Candida score
Supportive therapy