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Methyldopa
!  e? ! ympathoplegic, 
!  ? ! edation, po itive
coomb te t
e erpine
!  e? ! ympathoplegic, 
!  ? ! edation, depre ion,
na al tuffine ,
diarrhea
ydrochlorothiazide
!  e? ! iuretic, 
!  ? ! ypo-K, yperlipidemia,
hyperuricemia,
la itude, yper-|a,
yperglycemia
|lonidine
!  e? ! ympathoplegic, 
!  ? ! ry mouth, edation,
evere rebound 

uanethidine
!  e? ! ympathoplegic, 
!  ? ! rtho tatic  exerci e
hypoten ion, diarrhea,
exual dy fxn º
itroglycerin,  o orbide initrate
!  e? ! a odilatorͶangina, pulm edema,
aphrodi iac/erection enhancer º
! M ? ! elea e  from mooth mu cle:
increa ed c
M º relaxation.
ein  rterie
[ rhich doe rterie  ein ?
[   

! ecrea ed reload or !   
fterload? ! achycardia, lu hing,  ,
! oxicity hypoten ion, Monday i ea eͶ
decrea ed tolerance over eekend
º tach, dizzine and  on
reexpo ure
razo in
!  e? ! ympathoplegic, 
!  ? ! rtho tatic hypoten ion
ith  t do e, dizzine ,
headache
iazoxide
!  e? ! a odilator, 
!  ? ! yperglycemia,
decrea ed in ulin
relea e, hypoten ion
eta blocker
!  e? ! ympathoplegic, 
!  ? ! mpotence º, a thma,
cardiova cular effect
bradycardia, |, 
block), | effect Ͷ
edation and change in
leep
ydralazine
!  e? ! a odilator, evere , |
! Mechani m ! ncrea ed c
M º mooth mu cle
of ction? relaxation. rteriole  vein .
! educe !    a odilator )
preload or
afterload?
!  ? ! au ea, eadache, ÷  

  
 

 
, angina,  


!  e ith beta blocker to avoid tachycardia


and ith a diuretic to avoid alt retention
Minoxidil
!  e? ! a odilator, 
! Mechani m ! K channel opener, hyperpolarize
of ction? mooth mu cle cell
!  ? ! ° !"#$%&  
 
, reflex tachycardia, angina,
alt retention
!  e ith beta blocker to avoid
tachycardia and ith a diuretic to
avoid alt retention
|aptopril
!  e? ! | nhibitor, 
! ther xample ? ! nalapril, o inopril
!  ? ! yper-K, cough,
angioedema, ta te
change , hypoten ion,
fetal renal damage,
ra h, increa ed renin
examethonium
!  e? ! ympathoplegic, 
!  ? ! evere ortho tatic
hypoten ion, blurry
vi ion, con tipation,
exual dy fxn º
erapamil
!  e? ! |alcium |hannel locker,
, angina, arrhythmia ,
aynaud͛
! M ? ! lock oltage ependant ÷
  |a channel ,
decrea ing contractility
! More cardiac or ! |ardiac, but al o va odilator
mooth mu cle
effect ?
!  ? ! izzine , flu hing,
con tipation,  block,
au ea
! oxicity? ! |ardiac depre ion,
peripheral edema, flu hing,
dizzine , con tipation
r     M 
 
  ???
! hree drug in alphabetical order
[ #:  
! M ?
[ K channel openerͶhyperpolarize mooth mu cle
[ #2: enoldopam
! M ?
[ opamine eceptor goni t: relaxe va cular mooth mu cle
[ #3: itropru ide
! M ?
[ ncrea ed c
M via direct  relea e
!  ?
[ |  

itropru ide
!  e? ! a odilator, 
!  ? ! |yanide oi oning
elea e | )
r| r 
  
    
 |
   M ?
rhich are ok to u e in regnancy?)

   
M 
hi , on the other hand i  afe in pregnancy͙. º
iltiazem
!  e? ! |alcium |hannel locker,
, angina, arrhythmia ,
aynaud͛
! M ? ! lock oltage ependant ÷
  |a channel ,
decrea ing contractility
! More cardiac or ! omehere in the middle
mooth mu cle
effect ?
!  ? ! izzine , flu hing,
con tipation,  block,
au ea
! oxicity? ! |ardiac depre ion,
peripheral edema, flu hing,
dizzine , con tipation
o artan
!  e? ! ngioten in  eceptor
!
ood alternative to locker, 
hat? ! | nhibitor
!  ? ! etal renal toxicity,
yper-K
ifedipine
!  e? ! |alcium |hannel locker, ,
angina, aynaud͛
! M ? ! lock oltage ependant ÷ 
|a channel , decrea ing
! More |ardiac contractility
or mooth ! mooth mu cleͶva odilator
Mu cle
ffect ?
!  ? ! izzine , flu hing
! oxicity? ! |ardiac depre ion, peripheral
edema, flu hing, dizzine ,
con tipation
|   

! rhich i be t for decrea ed triglyceride ?
[ ibrate
[ xample ?
!
emfibrozil, |lofibrate, ezafibrate, enofibrate
! rhich are be t for decrea ing ?
[ tatin
[ M ?
! M
|o reducta e inhibitor Ͷinhibit chole trol precur or:
mevalonate
! rhich do patient hate taking becau e of

di turbance ?
[ ile cid e in : |hole tyramine  |ole tipol
! rhat are to other po ible drug you could u e?
[ |hole terol b orption locker  zetimibe) and iacin
nti-arrhythmic Ͷ
|
|  


|la 

|la 

|la 

|la 
nti-arrhythmic Ͷ
|
|  


|la  lock   odium channel re pon ible for pha e  depolarization


Quinidine, lecanide, rocainamide͙

|la 

|la 

|la 
nti-arrhythmic Ͷ
|
|  


|la  lock   odium channel re pon ible for pha e  depolarization


Quinidine, lecanide, rocainamide͙

|la  eta drenergic eceptor ntagoni t


ropranolol, Metoprolol͙

|la 

|la 
nti-arrhythmic Ͷ
|
|  


|la  lock   odium channel re pon ible for pha e  depolarization


Quinidine, lecanide, rocainamide͙

|la  eta drenergic eceptor ntagoni t


ropranolol, Metoprolol͙

|la  rolong action potential ith little effect on pha e 


depolarization, mo tly via blocking the K repolarizing current
miodarone, otalol, butilide͙

|la 
nti-arrhythmic Ͷ
|
|  


|la  lock   odium channel re pon ible for pha e  depolarization


Quinidine, lecanide, rocainamide͙

|la  eta drenergic eceptor ntagoni t


ropranolol, Metoprolol͙

|la  rolong action potential ith little effect on pha e 


depolarization, mo tly via blocking the K repolarizing current
miodarone, otalol, butilide͙

|la  lock lo -type |alcium |hannel


erapamil, iltiazem
|la  rug :
roken up by degree of a channel blockade and effect on  duration

|   rug
! M ?
[ Moderate blockade of a channel  rai e  thre hold and lo 
up troke. l o depre lope of pha e  depolarization.
!  e ?
[ ctopic foci and reentrant rhythm
[ trial  entricular rrhythmia
! xample ?
[ Quinidine, miodarone, rocainamide, i opyramide
! 
[ Quinidine
! |inconchi m:  , tinnitu , thrombocytopenia
! ncrea e  duration, increa ed effective refractory period, increa e Q
interval increa ed ri k of hat?)
! or ade de point
[ rocainamide
! ever ible  -like yndrome
|la  rug :
roken up by degree of a channel blockade and effect on  duration

|   rug
! M ?
[ old a channel , but unlike  ͛ horten duration of
 and refractory period
!  e ?
[ referentially act on di ea ed ti ue: i chemic or
depolarized urkinje/ventricular ti ue.
[
reat po t-M and for dig-induced arrhythmia
! xample ?
[ idocaine, Mexiletine, ocainide, henytoin?
! 
[ | depre ion/ tim and cardiova c depre ion
|la  rug :
roken up by degree of a channel blockade and effect on  duration

|  | rug
! M ?
[ Mo t potent odium channel blocker ecrea e up troke
of  and conduction velocity everyhere
[ o change in  duration
!  e ?
[ tach that progre to  and intractable 
[        |  | M 
! xample ?
[ lecanide, ncainide, ropafenone
! 
[ roarrhythmic, e p po t M: avoid in tho e ith heart
di ea eºincrea ed mortality
[ rolonged refractory period in  node.
|la  rug
! M ?
[ eta blocker : decrea ed c M and |a current . ecrea e lope
of pha e  depolarization.  node very en itive.
!  e ?
[ bnormal pacemaker , tach, , lo ventricular rate in a-fib
or a-flutter
! xample ?
[ ropranolol, molol, Metoprolol, tenolol, imolol
[ rhich one i uper hort acting?
! M
! 
[ mpotence º, a thma exacerbation, bradycardia,  block,
|, edation, leep change
[ rhy u e ith caution in diabetic ?
! Ma k effect of hypoglycemia
[ Metoprolol
! y lipidemia
|la  rug
! M ?
[ ota ium |hannel locker : increa e  duration
!  e ?
[ u ed hen other drug fail
! xample ?
[ otalol, butilide, retylium, miodarone
[ rhich i good for rolf-arkin on-rhite?
! miodarone
! 
[ otalol
! ncrea ed Q ntervalͶhy i thi bad?
[ ncrea ed ri k of tor ade de point
! xce ive beta block
[ butilide
! or ade
[ retylium
! rrhythmia , hypoten ion
[ miodarone
! ulm fibro i , corneal depo it , epatotoxicity, photodermatiti , euro  , con tipation,
bradycardia, heart block, hypothyroid, hyperthyroid
! | |K ͛ ,  , and 
|la  rug
! M ?
[ |alcium |hannel locker :  node: decrea ed
conduction.
[  e ?
! pecially good for?
[ 

! xample ?
[ erapamil and iltiazem for nti-arrhythmic
! 
[ |on tipation, flu hing, edema, | effect ,
tor ade
deno ine
! M
[ ncrea ed K efflux: hyperpolarization.
! rug of choice for hich condition ?
[  nodal arrhythmia .
! hort or long acting?
[ ery hort  econd )
! oxicity
[ lu hing, ypoten ion, |he t pain
ota ium
! M
[ ecrea e ectopic pacer in hypokalemia
! rug of choice for hich condition ?
[ ig toxicity
Magne ium
! rug of choice for hich condition ?
[ or ade and dig toxicity