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It is a benign neoplasm
of the chorionic villi
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÷oung mothers (under age 20 years) have a slightly
higher prevalence of GTD, although not nearly so great
as those mothers over age 35 years.
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develop choriocarcinoma (but not hydatidiform mole);
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V hydatidiform mole is an abnormality of fertilization

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It is the result of It is the result of


fertilisation of anucleated
fertilisation of an
ovum ( has no chromosomes)
with a sperm which will
ovum by 2 sperms so
duplicate giving rise to '6 the chromosomal
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The cytotrophoblast is The intermediate


trophoblast has features
The syncytiotrophoblast,
a stem cell with high which constitutes the
mitotic activity but of the other two
components and is villous trophoblast, has low
without hormonal
synthesis. responsible for mitotic activity. The
endometrial invasion and syncytiotrophoblast is
implantation responsible for the
synthesis of the (beta-hCG)
and can be identified with
immunohistochemical
stains.
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 shows trophoblastic
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There is no vasculature in the
chorionic villi leads to early
death and absorption of the
embryo.

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?igh hCG causes:
multiple theca lutein exaggeration of the
cysts in the ovaries normal early
in about 50% of pregnancy symptoms
cases.
and signs
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auniaux E, Campbell S. lacenta and Cord. In: Dewbury K, Meire ?, Cosgrove D, eds.
Ultrasound in Obstetrics and Gynecology. London, United Kingdom. Churchill Livingstone
1993;448-9.
Freeman SB, riest ?, Macmahon WC, Fernhoff M, Elsas L. renatal ascertainment of
triploidy by maternal serum alpha-fetoprotein screening. renat Diagn 1989;9:339-47.
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dilatation and suction curettage (at which time the diagnosis is confirmed).

15% of women with complete hydatidiform mole will develop recurrent disease in the form
of invasive mole or choriocarcinoma.

all patients are followed up with successive serum beta-hCG measurements to allow early
detection of persistent gestational trophoblastic neoplasia

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IF serial testing shows progressive decrease in the serum beta-hCG level

The clinical diagnosis of complete hydatidiform mole is reached.


        
  


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