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DEVELOPMENT OF PUD
DANIEL GHOSSEIN
INTRODUCTION
• Less mucus and bicarbonate are produced, making the gastric epithelial cells more vulnerable
to damage by hydrochloric acid and pepsin.
SOME OF THE CYTOPROTECTIVE MECHANISMS OF
PGS INCLUDE:
• NSAIDs are weak acids and, thus, are nonionized in the acidic environment, allowing them to diffuse
readily into the gastric mucosal cells and leading to subepithelial hemorrhage and cell necrosis.