Acute Pharyngitis • Pharyngitis refers to inflammation of the pharynx, including erythema, edema, exudates, or an enanthem (ulcers, vesicles) • related to environmental exposures • Acute infections of the upper respiratory tract account for a substantial number of visits to pediatricians and many feature sore throat as a symptom or evidence of pharyngitis on physical examination Infection Etiologies Infection Etiologies –Virus– • Herpes simplex virus infection; • Gingivostomatitis and ulcerating vesicles throughout the anterior pharynx and on the lips are seen in primary oral. • High fever and difficulty taking oral fluids are common. This infection can last for 14 days • Enteroviruses; • Discrete papulovesicular lesions or ulcerations in the posterior oropharynx, severe throat pain, and fever are characteristic of herpangina Infection Etiologies –Virus– • Hand-foot-mouth disease; • Vesicles or ulcers throughout the oropharynx, vesicles on the palms and soles, and sometimes on the trunk and extremities. • Coxsackie a16 is the most common agent, but enterovirus 71 and coxsackie a6 can also cause this syndrome • Adenoviruses cause pharyngitis. When there is conccurrent conjunctivitis the syndrome is called pharyngoconjunctival fever. • The pharyngitis tends to resolve within 7 days but conjunctivitis may persist for up to 14 day • Outbreaks of a unique clinical illness caused by adenovirus types 3, 7, 2, 4, 7a, 11, and1 4, called pharyngoconjunctival fever Infection Etiologies –Virus– • Measles Intense, diffuse pharyngeal erythema and Koplik spots, the pathognomonic enanthem • Epstain-Barr virus Splenomegaly or hepatomegaly • infectious mononucleosis adolescent with exudative tonsillitis • Primary infection with HIV; • acute retroviral syndrome, with non-exudative pharyngitis, fever, maculopapular rash, arthralgia, myalgia, adenopathy, and often a maculopapular rash. Infection Etiologies – Bacteria – • Group C and Group G streptococcus and A. haemolyticum pharyngitis have been diagnosed most commonly in adolescents and adults. • F. necrophorum has been suggested to be a fairly common cause of pharyngitis in older adolescents and adults (15-30 yr old) • F. necrophorum pharyngitis is associated with development of Lemierre syndrome, internal jugular vein septic thrombophlebitis. • symptoms may persist, neck pain and swelling develop, and the patient appears toxic Infection Etiologies – Bacteria – • Gonococcal pharyngeal infections are usually asymptomatic but can cause acute pharyngitis with fever and cervical lymphadenitis. • Corynebacterium diphtheria; • Physical findings are bull neck (extreme neck swelling) and a gray pharyngeal pseudomembrane that can cause respiratory obstruction. • M. Pneumoniae and C. Pneumoniae are may also have same sign and symptom like C.Diphtheria. Severe or persistent cough subsequent to pharyngitis may be the clue to infection with one of these organisms Infection Etiologies – Group A Streptococcus – • quite common among children 5-15 yr old. • incubation period of 2-5 days, pharyngeal infection rapid onset of significant sore throat and fever. • The pharynx is red, the tonsils are enlarged and often covered with a white, grayish, or yellow exudate that may be blood-tinged. • There may be petechiae or “doughnut” lesions on the soft palate and posterior pharynx and the uvula may be red and swollen • strawberry tongue / white strawberry tongue Infection Etiologies – Group A Streptococcus – • Enlarged and tender anterior cervical lymph nodes. • Ear pain is a frequent complaint but the tympanic membranes are usually normal. • Patients with gas that produce exotoxin a, b, or c may demonstrate the fine red, papula rash of scarlet fever. • Begins on the face and then becomes generalized. • Rash blanches with pressure and it may be more intense in skin creases, especially in the antecubital fossae, axillae, and inguinal creases (pastia’s lines or pastia’s sign) Clinical Manifestation • Infection begins with the typical signs and symptoms of pharyngitis such as sore throat, dysphagia, and fever, usually in an older child who often has a history of recurrent tonsillitis • Systemic symptoms such as malaise, poor appetite, and chills appear early, and mild dehydration may develop. • The child has a toxic appearance, and trismus almost always occurs. Characteristic signs are a muffl ed (hot potato) voice, trismus, and major leucocytosis. Diagnosis • Diagnosis ditegakkan berdasakan gejala klinis, pemeriksaan fisis dan pemeriksaan laboratorium • Pemeriksaan baku emas pemeriksaan kultur dari apusan tenggorok • Untuk mendeteksi Streptococcus Gorup A Rapid Antigen Detection Tests • Test Serologi baik dilakukan bila curiga terdapat infeksi EBV • WBC Count paling baik dilakukan untuk infeksi CMV (terdapat limfositosis dengan gambaran atypical lymphocyte) Criteria McIsaac • McIsaac Score ≥ 4 is associated with positive laboratory test for GAS in less than 70% of children with pharyngitis. Treatment • Symptomatic therapy; • Oral antipyretic/analgesic agent (acetaminophen or ibuprofen) fever and sore throat pain • Systemic corticosteroids evidence of upper airway compromise due to mononucleosis • Corticosteroid connot be recommended for treatment of most pediatric pharyngitis. Antibiotic Therapy Recurrent pharyngitis • Reinfection with the same M type if type-specific antibody has not developed • Poor compliance with oral antibiotic therapy • Macrolide resistance if a macrolide was used for treatment • Infection with a new M type. • Treatment with intramuscular benzathine penicillin eliminates nonadherence to therapy Complication and Prognosis • Bacterial middle ear infections and bacterial sinusitis • Complications of GAS pharyngitis include • Local suppurative complications, such as parapharyngeal abscess • Nonsuppurative illnesses; • ARF (Acute Rheumatic Fever) • APSGN (Acute Post Streptococcal Glomerulonephritis) • Poststreptococcal reactive arthritis • PANDAS (Pediatrics Autoimmune Neuropsychiatric Disorders Associated With S. Pyogenes) • CANS (childhood acute neuropsychiatric symptoms). Tonsilitis • Acute Infection • Most episodes of acute pharyngotonsillitis are caused by viruses • Group A β-hemolytic streptococcus (GABHS) is the most common cause of bacterial infection in the pharynx. • Chronic Infection chronically infected by multiple microbes; • β-lactamase– producing organisms • aerobic species H. Inffluenzae • anaerobic species Peprosteptococcus, Prevotella, Fusobacterium Clinical Manifestation – Acute Infection – • Symptoms of GABHS infection include; • Odynophagia, dry throat, malaise, fever and chills, dysphagia, referred otalgia, headache, muscular aches, and enlarged cervical nodes. • Signs include; • Dry tongue, erythematous enlarged tonsils, tonsillar or pharyngeal exudate, palatine petechiae, and enlargement and tenderness of the jugulodigastric lymph nodes Clinical Manifestation – Chronic Infection – • halitosis, chronic sore throats, foreign-body sensation, or a history of expelling foul-tasting and foul-smelling cheesy lump. • Examination reveals tonsils of a range of sizes which often they contain copious debris within the crypts. Clinical Manifestation – Airway Obstruction– • Daytime symptoms chronic mouth breathing, nasal obstruction, hyponasal speech, hyposmia, decreased appetite, poor school performance, and, rarely, symptoms of right-sided heart failure. • Nighttime symptoms loud snoring, choking, gasping, frank apnea, restless sleep, abnormal sleep positions, somnambulism, night terrors, diaphoresis, enuresis, and sleep talking Treatment – Medical Management – Tonsillectomy Acute Infectious Laryngitis • Viruses cause most cases; diphtheria is an exception but is extremely rare in industrialized countries. • onset is usually characterized by an upper respiratory tract infection during which sore throat, cough, and hoarseness. • Hoarseness and loss of voice may be out of proportion to systemic signs and symptoms. • Epinephrine (1 : 1,000 dilution in dosage of 0.01 ml/kg to a maximum of 0.5 ml/dose) administered intramuscularly. • Corticosteroids are often required (1-2 mg/ kg/24 hr of prednisone for 3-5 days) Acute Epiglottitis • Characterized by an acute rapidly progressive and potentially fulminating course of high fever, sore throat, dyspnea, and rapidly progressing respiratory obstruction. • Drooling is usually present and the neck is hyperextended in an attempt to maintain the airway. • The child may assume the tripod position, sitting upright and leaning forward with the chin up and mouth open while bracing on the arms. Infection Etiologies • H. Influenzae most common • Other S. aureus, S. pnemoniae, C. albicans, virus, trauma Acute Epiglottitis • The diagnosis requires visualization under controlled circumstances of a large, cherry red, swollen epiglottis by laryngoscopy. • Classic radiographs of a child who has epiglottitis show the thumb sign Treatment • All patients should receive oxygen route unless the mask causes excessive agitation. • Establishing an airway by endotracheal or nasotracheal intubation or, less often, by tracheostomy is indicated in patients with epiglottitis. • Cultures of blood, epiglottic surface, and, in selected cases, cerebrospinal fluid should be collected after • Cefotaxime, ceftriaxone, or meropenem should be given parenterally, pending culture and susceptibility reports, because 10-40% of H. influenzae type b cases are resistant to ampicillinr the airway is stabilized Retropharyngeal Abscess Lateral Pharyngeal (Parapharyngeal) Abscess • Occurs most commonly in children younger than 3-4 yr of age • Clinical manifestations of retropharyngeal abscess are nonspecific and include fever, irritability, decreased oral intake, and drooling. • Neck stiffness, torticollis, and refusal to move the neck may also be present. • Muffled voice, stridor, respiratory distress, or even obstructive sleep apnea. Retropharyngeal Abscess Lateral Pharyngeal (Parapharyngeal) Abscess • Physical examination can reveal bulging of the posterior pharyngeal wall, although this is present in • Cervical lymphadenopathy may also be present. • Lateral pharyngeal abscess commonly presents as fever, dysphagia, and a prominent bulge of the lateral pharyngeal wall, sometimes with medial displacement of the tonsil. Infection Etiologies • Retropharyngeal and lateral pharyngeal infections usual pathogens include; • group A streptococcus • Staphylococcus aureus • S. aureus MRSA • Other pathogens: Haemophilus influenzae, Klebsiella, and Mycobacterium avium-intracellulare Differential Diagnosis • Acute epiglottitis • Foreign body aspiration • neck mobility • meningitis Diagnosis • Incision and drainage and culture of an abscessed node provides the definitive diagnosis • CT can be useful in identifying the presence of a retropharyngeal, lateral pharyngeal, or parapharyngeal abscess Treatment • Intravenous antibiotics with or without surgical drainage. • Third-generation cephalosporin combined with ampicillin-sulbactam or clindamycin to provide anaerobic coverage is effective. • Drainage is necessary in the patient with respiratory distress or failure to improve with intravenous antibiotic treatment Complications • Significant Upper Airway Obstruction • Rupture Leading To Aspiration Pneumonia • Extension To The Mediastinum • Thrombophlebitis Of The Internal Jugular Vein • Erosion Of The Carotid Artery Sheath Croup (Laryngotracheobronchitis) • Viruses typically cause croup, the most common form of acute upper respiratory obstruction. • Most patients have an upper respiratory tract infection with some combination of rhinorrhea, pharyngitis, mild cough, and low-grade fever for 1-3 days before the signs and symptoms of upper airway obstruction become apparent. • The characteristic “barking” cough, hoarseness, and inspiratory stridor • Symptoms are characteristically worse at night and often recur with decreasing intensity for several days and resolve completely within a week Croup (Laryngotracheobronchitis) • Child may prefer to sit up in bed or be held upright • Physical examination can reveal a hoarse voice, coryza, normal to moderately inflamed pharynx, and a slightly increased respiratory rate • Nasal flaring, suprasternal, infrasternal, and intercostal retractions • Continuous stridor. • The child who is hypoxic, cyanotic, pale, or obtunded needs immediate airway management. Diphtheria • Diphtheria is an acute toxic infection caused by corynebacterium species, typically corynebacterium diphtheria. • Corynebacteria are aerobic, nonencapsulated, non–spore-forming, mostly nonmotile, pleomorphic, gram-positive bacilli. • Cystine-tellurite blood agar or tinsdale agar • Spread is primarily by airborne respiratory droplets, direct contact with respiratory secretions of symptomatic individuals, or exudate from infected skin lesions Pathogenesis • C. diphtheria exotoxin, which inhibits protein synthesis and causes local tissue necrosis. • 1st few days of respiratory tract infection (usually in the pharynx), a dense necrotic coagulum of organisms, epithelial cells, fibrin, leukocytes, and erythrocytes forms, advances, and becomes a gray- brown, leather-like adherent pseudomembrane (Diphthera is Greek for leather). • Paralysis of the palate and hypopharynx is an early local effect of diphtheritic toxin Clinical Manifestation (Respiratory Tract) • After incubation period of 2-4 days, local signs and symptoms of inflammation develop. • Infection of the anterior nares is more common among infants and causes serosanguineous, purulent, erosive rhinitis with membrane formation. • Shallow ulceration of the external nares and upper lip is characteristic • Unilateral or bilateral tonsillar membrane formation, which can extend to involve the uvula, soft palate, posterior oropharynx, hypopharynx, or glottic areas • Enlarged lymph nodes can cause a bull-neck appearance Diagnosis • History • Immunization • Sign and symptoms • Specimens for culture should be obtained from the nose and throat and any other mucocutaneous lesion Complications • Toxic Cardiomyopathy • Toxic Neuropathy Treatment • Antitoxin; • Equine antitoxin intravenous administration of antitoxin is preferred • Before intravenous administration of antitoxin, tests for sensitivity to horse serum should be performed according to instructions provided with the material Treatment – Antitoxin – • Suggested dose ranges are: • Pharyngeal or laryngeal disease of 2 days’ duration or less, 20 000 to 40 000 U • Nasopharyngeal lesions, 40 000 to 60 000 U; • Extensive disease of 3 or more days’ duration or diffuse swelling of the neck, 80 000 to 120 000 U Treatment – Antimicrobial Therapy – • Erythromycin PO for 14 days • Aqueous penicillin G administered intravenously for 14 day or, • penicillin G procaine administered intramuscularly for 14 days • Prevention Immunization Jadwal Imunisasi