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PHARMACODYNAMICS

AND
PHARMACOKINETICS
BAIHANNAH M. PANGALAO
PHARMACOLOGY INSTRUCTOR
• PK: How does the drug concentration change as it moves
through the different compartments of your body

• PD : How does the drug exert its effect on your body

Book definition:
PK : What your body does to the drug
PD : What the drug does to your body
•Pharmacokinetics
•– how does the
•human body
•act on the drugs?
Components of PK ( In vs Out )
Absorption
- The process of the substance entering the blood
circulation

Distribution
- The dispersion of a substance throughout fluids and
tissues of the body

Metabolism
- The irreversible transformation of parent compounds into
daughter compounds

Elimination
- The removal of the substances from the body