WHAT IS HYPERTENTION

HYPERTENTION
 High blood pressure (HBP)or hypertension
means high pressure (tension) in the arteries .

 High blood pressure does not mean excessive

emotional tension, although emotional
tension and stress can temporarily increase
blood pressure.
RANGES OF BLOOD PRESSURE

 Normal blood pressure is below 120/80.

 Blood pressure between 120/80 and

139/89 is called pre-hypertension.

 Blood pressure of 140/90 or above is

considered High Blood Pressure.
EFFECTS OF HYPERTENTION
 Coronary artery dieases

 Left ventricular hypertrophy

 Acute myocardial infarction

 Cerebral hemorrhage
 HYPERTENTION TREATMENT

Calcium Channel Blockers

 ACE Inhibitors

 Angiotensin II Receptors Blockers (ARB)

 Beta Blockers

 Diuretics

 Direct Renin Inhibitors

 CALCIUM CHANNEL BLOCKER’S

BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

ADALAT Nifedipine Bayer 10mg 3.56

20mg 4.90

NORVASC Amlodipine Pfizer 5mg 11.92

10mg 23.33

HERBESSER Diltiazem Highnoon 30mg 3.78

60mg 6.88
SR 90mg SR 13
180mg 24
CALAN SR Verapamil SEARLE 240mg SR 7
 ACE INHIBITOR’S
BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

CAPOTEN Captopril B-MS 25mg 6.67

50mg 13

RENITEC Enalapril MSD 5mg 5

10mg 9.23
20MG 18

ZESTRIL Lisinopril ICI 5mg 5.47

10mg 10.73
20mg 21

COVERSYL Perindopril SERVIER 2mg 9.90

4mg 14.90
8mg 23.5
 BETA BLOCKER’S
BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

MEPRESOR Metoprolol Novartis 100mg 6.25

TENORMIN Atenolol ICI 25 mg 5

50mg 6
100mg
9
CONCOR Bisoprolol Merck 2.5mg 4.29
5mg 9.37
10mg 17.47

CARLOV Carvedilol Hilton 6.25mg 5.5

12.5mg 8.5
25mg 14.5
 ANGIOTENSIN II RECEPTOR
BLOCKER’S
BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

COZAAR Losartan potassium MSD 50mg 51.67

100mg 80

DIOVAN Valsartan Novartis 80mg 37.64

160mg 57

ADVANT Candesartan Getz 8mg 11

16mg 20

OMSANA Olmesartan Hilton 20mg 16

40mg 28
 DIURETICS
BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

ALDACTONE Spironolactone Searle 25mg 1.5

100mg 7.7

LASIX Frusemide Sanofi Aventis 20mg 1

40mg 1.65
Inj 5

LASORIDE Frusemide/ Amiloride Sanofi Aventis 40mg/ 5mg 3.32

SPIROMIDE Spironolactone/ SEARLE 20mg 3.7

Frusemide 40mg 5.24
 DIRECT RENIN INHIBITOR’S
BRAND NAME GENERIC NAME COMPANY AVAILBILTY PRICE

RAZILES Alkesrin Novartis 150mg 70

300mg 120
 BRITISH HYPERTENTION SOCIETY

 BHS says that for the treatment of

hypertension
 CCB,s ARB,s ACEI,s and Diuretics are first

line treatment where as BB,s are demoted

on the last option due to 28% onset of
diabetes in young hypertensive patients.
ALL CLINICAL DATA SUGGESTS
 At least II drugs are require to achieve the goal.

 Previously the combination's are used for

hypertension

 A+B C+D

 Now A+C A+D

 KYOTO HEART STUDY

Background:
 Effects of Valsartan on morbidity and mortality in
uncontrolled hypertensive patients with high
cardiovascular risks.

Objective:
 The objective was to assess the add-on effect of
Valsartan on top of conventional treatment for
high-risk hypertension in terms of the morbidity
and mortality.
Methods:

It was a multicentre, Prospective Randomised Open Blinded
Endpoint (PROBE) design study.
 3031 patients (43% female age 66) with uncontrolled
hypertension.

Treatment:
 Valsartan or non ARB for 3.27 years. Baseline blood pressure was
157/88 and at the end was 133/76.

Conclusion:
 Valsartan add-on treatment to improve blood pressure control
prevented more cardiovascular events than conventional non ARB
treatment in high risk hypertensive patients.
 EXTOR (Amlodipine / Valsartan)
 FDA has approved Extor is first line
treatment for stage II hypertensive
patients.
 80% of patients are not on goal with
monotherapy.
 Extor also improves CV out comes.
 Extor is a need of every hypertensive
which further reduce complications.