Organizing Medical

Research Papers (5)

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Radiation exposure increases the risk of cancer among the
general population, as evidenced by medical radiation or radiation-
contaminated environments such as 60Co contaminated buildings,
nuclear power plants, professional use of radiation and radioactive
substances. Given the complexity of radiation exposure in Taiwan,
more thoroughly understanding irradiation safety-related issues is of
priority concern.
Despite the use of radiation dosimetery for acute high dose
exposure as an effective means of estimating the exposure for
individuals chronically exposed to ionizing radiation over a protracted
period, dose reconstruction for individuals with previous long-term and
low dose-rate radiation exposure has seldom been examined,
especially when attempting to assess ionization radiation in order to
define low dose rate exposures.
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Exposure to high dosages of ionizing radiation may
increase the incident rate of various cancers. For instance, more than
200 buildings constructed in Taiwan since 1982 were found to contain
cobalt-60 contaminated steel. The rate at which individuals receive
long-term and low dose-rate radiation exposure ranges from 0.50 to
500.00 uSv/hour, while the background dose rates in most buildings in
Taiwan range from around 0.08 to 0.10uSv. Exposure to a low dose of
ionizing radiation over an extended period of time leads to chronic
illnesses.
While possibly damaging DNA and creating errors in
DNA transcription, ionizing radiation may also directly induce the death
of cells or cause gene mutation, subsequently increasing the incidence
rate of cancer. The lack of an effective low dose rate assessment
strategy for radiation-contaminated buildings, nuclear power plants,
professional use of radiation and radioactive substances) poses a
major health threat to the general public.

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Based on the above, we should develop a low level dose mode
method, capable of accurately predicting the radiation dosage levels in the
surrounding environment of a nuclear power plant that could potentially harm
humans.
To do so, radiation dosage distribution and adverse health
impact on neighboring residents can be estimated using the physics dose
mode method with simplified calculations of the mean and standard deviation.
Biological dose models can then be used to relate the location and biological
effects to the controlled exposure factor levels. Next, an optimal combination of
process parameters can be obtained using the estimated risk dosage method.
As anticipated, the proposed low level dose mode method can
analyze the dosage levels of radiation among neighboring residents of a nearby
nuclear power plant. Analysis results of dosage levels inform residents of the
health impact of low level radiation, hopefully leading to a lower dose rate and
occurrence of cancer.
Importantly, the low level dose mode method can enable medical
personnel to estimate the radiation dosage distribution among neighboring
residents near a nuclear power plant, providing a valuable reference for
governmental authorities in establishing legislation to protect inhabitants from
unsafe radiation levels.
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As is well known, silver nanoparticles have an affinity with a
proteins thiol and amino group. Surface plasma resonance (SPR), a
biosensor, can detect proteins because silver nanoparticles have a coating on
SPR, necessitating the ability to use SPR sensitively and accurately to detect
proteins. For instance, a protein containing amyloid B-derived diffusible
ligands (ADDLs) causes Alzheimers disease.
Although local SPR (LSPR) is more sensitive and accurate than the
conventionally adopted SPR, LSPR has many nanostructures, explaining why
sensitivity and accuracy are of priority concern. Moreover, the conventionally
adopted SPR is more expensive than LSPR.
While the sensitivity of SPR is 100pM, LSPR must have a
higher sensitivity and accuracy, hopefully below 1pM.
Developing a biosensor without a LSPR would lead to a more
expensive detector. Moreover, the inability to increase the sensitivity and
accuracy of a biosensor makes it impossible to detect the biomolecular
structure in early stages, subsequently creating greater problems such as an
increased societal burden in caring for such patients.
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Based on the above, we should design a sensitive and accurate
biosensor that can identify special proteins efficiently, as well as detect certain
diseases in their early stages. For instance, identifying the protein ADDLs early
can be used to diagnose Alzheimers disease in its early stages so that
therapeutic treatment can be administered.
To do so, nanoparticles can be developed in a glass chamber,
followed by the design of a LSPR biosensor. The biomolecular structure can
then be detected using LSPR, enabling us to identify the disease.
As anticipated, the proposed analytical method for detecting bio
molecular structures can detect solution consistency below 1pM with a high
degree of accuracy.
Moreover, the proposed LSPR biosensor can provide a highly
sensitive and accurate means of detecting the bio molecular structure. The
ability to identify the disease in its early stages can lead to earlier treatment and
recoery. For instance, Alzheimers disease can be diagnosed early because
LSPR can detect ADDLs with a high degree of sensitivity, ultimately increasing
the survival rate of patients.
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