Writing Problem and Hypothesis

Statements for Medical Research(6)

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Setting of work proposal :
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Work problem :
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Quantitative specification of problem :

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Importance of problem :
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Project need : ,
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Work objective : ?
Methodology to achieve objective
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Anticipated results :
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Contribution to field :
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To determine the radioactivity levels in the human brain,
uptake radiopharmaceuticals can be used in brain imagery to
accurately diagnose the early stages of brain-related diseases.
However, according to clinical studies, the amount and
concentration of brain uptake radiopharmaceuticals have a low stability,
making it impossible to diagnose brain-related diseases accurately and
efficiently. (NOTE : Add 2-4 sentences that describe characteristics of
the problem or statistics that reflect its severity) More
specifically, the chemical structures of traditional radiopharmaceuticals
(ECD) have too many sulfur chemical complexes, resulting in
radioactivity in the liver. Simultaneously, the uptake of
radiopharmaceuticals in brain radioactivity becomes increasingly lower,
ultimately making it increasingly difficult to accurately diagnose brain-
related diseases for clinical purposes. Therefore, a high
lipophilicity radiopharmaceutical method must be developed that uses
two groups of radiochemistry, i.e. aminedithiolate ligand (ONS) and
monothiolate coligand (S), to increase the radiopharmaceutical high
lipophilicity level in order to maintain a radiopharmaceutical stability
and hyperactivities.
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A high lipophilicity radiopharmaceutical method can be
developed that uses two groups of radiochemistry, i.e. aminedithiolate
ligand (ONS) and monothiolate coligand (S), to increase the
radiopharmaceutical high lipophilicity level in order to maintain a
radiopharmaceutical stability and hyperactivities. To
do so, aminedithiolate and monothiolate can be used to one part of
combined 99mTcs 1 ligand 99mTcs 3 ligands. In the new
radiopharmaceutical, its radiochemical characteristics can then be
analyzed using a high performance liquid chromatographic (HPLC),
with its amount subsequently analyzed using a thin layer
chromatography (TLC). Next, the characteristics of high lipophilicity can
be analyzed using a Partition coefficient Using this radiopharmaceutical
sample, its radioactivity can be analyzed as well using an automatic
gamma counter. Radiation tracer characteristics can be analyzed using
multiple-channel pulse wave equipment. Additionally, the new
radiopharmaceutical serum can be injected into laboratory mice, with
the radiopharmaceutical uptake number of each mouse organ analyzed
as well. Following sacrifice of those mice with significant organs
extracted,the organs can be weighed and their radioactivity levels
determined as well. Finally, the biodistribution in laboratory mice can be
analyzed.
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As anticipated, the proposed high lipophilicity
radiopharmaceutical method can ensure stability in a mouses brain
with an uptake number exceeding 15% and other organs uptake
numbers lower than 30%. New radiopharmaceuticals can maintain
stability six hours after fabrication. Blood clearing ratio can then be
lower than traditional radiopharmaceuticals used in brain imagery.
Results of this study can contribute to efforts to increase the
clinical accuracy of diagnosing brain diseases as early as possible for
curative purposes, thus enhancing a physicians ability to achieve ideal
patient management, improve a patients quality of life, decrease both
the mortality rate associated with brain-related diseases and the
relapse rate and, ultimately, lower the radiation dose of patients with
brain-related diseases. (NOTE : Add 1-2 more sentences that
describe more thoroughly how the proposed method contributes to a
particular field or sector)
()
Computer tomography (CT) plays a prominent role in diagnosing medical
ailments owing to its ability to achieve precise treatment without unnecessarily high
radiation levels that would harm patients. Restated, while effective in therapeutic
treatment, CT can not be used during a routine examination. Efforts to integrate CT into
routine examinations is thus of priority concern. Although medical images are
normally taken through conventional x-ray procedures, such procedures are limited in
that while confined to capturing three-dimensional objects, many organs overlap each
other, making it impossible to distinguish between them. Conversely, CT can not only
detect diseases in their early stages, but also more effectively treat diseases.
Nevertheless, CT is not adopted in routine examinations owing to its higher radiation
dose than in normal examinations. Conventional medical imagery procedures emit a low
radiation dose owing to the limited exposure time. For instance, a
normal chest x-ray examination, a radiation dosage of only 0.5mGy poses a relatively low
risk to the human body. However, a CT examination may contain ten to twenty times
higher dosage levels than a conventional x-ray examination would owing to the longer
exposure time, possibly causing human injury. Despite the advantages
of CT images over those of conventional x-ray images, the inability to reduce its radiation
dose to a safe level makes it impossible to detect and subsequently treat cancer in its
early stages. The feasibility of accelerating the scanning time during a CT examination
must be examined, thus reducing radiation dose levels. Therefore, the
feasibility of accelerating the scanning time during a CT examination must be examined,
thus reducing radiation dose levels.
()
The feasibility of accelerating the scanning time during a CT
examination can be examined, thus reducing radiation dose levels. Whereas
the human body is not proportional with respect to thickness, the absorbed
radiation dosage is all the same. To do so, the ability to
ensure that the human body absorbs a lower radiation dose with respect to
thickness, CT can be verified as an effective physical examination procedure
for prevention purposes (NOTE: Add 2-3 more sentences to more describe the
methodology more completely). As anticipated, analysis results
can indicate that the accelerated CT scan speed can scan front and rear
positions of the body at varying thicknesses and radiation dosages,
subsequently reducing a substantial amount of nonessential dosage and
making CT highly promising as a preventive medicine procedure. Such a
procedure would significantly contribute to treatment of lung cancer patients
since MRI does not have a spoke beam. Given that the lower number of
hydrogen atoms in the lungs does not provide adequate information for the
image signal of MRI However, CT can produce an accurate image of the lungs,
making it relatively easy to detect lung cancer in its early stages.
Results of this study can demonstrate the ability of CT to reduce the radiation
dose level, makes it highly promising as a preventive measure during physical
examinations to detect lung cancer in its early stages. (NOTE : Add 2-4
sentences that describe more thoroughly how the proposed method contributes
to a particular field or sector)
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