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I||||ng Cf nard

Ge|at|n Capsu|es
5ubm|tted by ť
5|mran[|t 5|ngh
MŦÞharmŴ 2
nd
5em
5ubm|tted to ť
DrŦ 5wat| Gupta
Mater|a|s that can be f|||ed
|nto hard ge|at|n capsu|esť
Þowders/Cranules
ÞelleLs
1ableLs
as|c 5teps |nvo|ved |n the
f||||ng of hard ge|at|n capsu|esť
upplv of LmpLv Capsules upplv of LmpLv Capsules
Allanlna and 8ecLlflcaLlon Allanlna and 8ecLlflcaLlon
Cpenlna and eparaLlon Cpenlna and eparaLlon
lllllna of Þowder Cranules/ÞelleLs lllllna of Þowder Cranules/ÞelleLs
!olnlna and Closlna !olnlna and Closlna
ulscharae ulscharae
Ŧ kect|f|cat|onť
W 1he empLv capsules are orlenLed so LhaL all polnL ln Lhe same
dlrecLlonŦ lŦeŦţ bodv end downwardŦ
W A speclallv deslaned blade pushes aaalnsL Lhe capsule and
causes lL Lo roLaLe abouL lLs cap end as a fulcrumŦ
W AfLer Lwo pushes (one horlzonLallv and one verLlcallv
downward)ţ Lhe capsules wlll alwavs be allaned bodv end
downward reaardless of whlch end enLered Lhe channel flrsLŦ
W 1he empLv capsules are orlenLed so LhaL all polnL ln Lhe same
dlrecLlonŦ lŦeŦţ bodv end downwardŦ
W A speclallv deslaned blade pushes aaalnsL Lhe capsule and
causes lL Lo roLaLe abouL lLs cap end as a fulcrumŦ
W AfLer Lwo pushes (one horlzonLallv and one verLlcallv
downward)ţ Lhe capsules wlll alwavs be allaned bodv end
downward reaardless of whlch end enLered Lhe channel flrsLŦ
2Ŧ 5eparat|on of caps from bod|esť
W 1hls process depends on Lhe dlfference ln dlameLers
beLween cap and bodv porLlonsŦ
W Pereţ Lhe recLlfled capsules are dellvered bodv end flrsL
lnLo Lhe upper porLlon of spllL bushlnas or spllL fllllna
rlnasŦ
W A vacuum applled from below pulls Lhe bodles down lnLo
Lhe lower porLlon of Lhe spllL bushlnaŦ
W 1he dlameLer of Lhe caps ls Loo larae Lo allow Lhem Lo
follow Lhe bodles lnLo Lhe lower bushlna porLlonŦ
W 1he spllL bushlnas are Lhen separaLed Lo expose Lhe
bodles for fllllnaŦ
W 1hls process depends on Lhe dlfference ln dlameLers
beLween cap and bodv porLlonsŦ
W Pereţ Lhe recLlfled capsules are dellvered bodv end flrsL
lnLo Lhe upper porLlon of spllL bushlnas or spllL fllllna
rlnasŦ
W A vacuum applled from below pulls Lhe bodles down lnLo
Lhe lower porLlon of Lhe spllL bushlnaŦ
W 1he dlameLer of Lhe caps ls Loo larae Lo allow Lhem Lo
follow Lhe bodles lnLo Lhe lower bushlna porLlonŦ
W 1he spllL bushlnas are Lhen separaLed Lo expose Lhe
bodles for fllllnaŦ
Ŧ Dos|ng of I||| Mater|a|sť
Iarlous meLhods are emploved for lLŦ Iarlous meLhods are emploved for lLŦ
llaŦ Iacuum asslsLed Capsule openlna ln auLomaLed
CapsuleŴlllllna Machlne
llaŦ Iacuum asslsLed Capsule openlna ln auLomaLed
CapsuleŴlllllna Machlne
Ŧ kep|acement of caps and e[ect|on of f|||ed capsu|esť
W 1he cap and bodv bushlna porLlons are re[olnedŦ
W Þlns are used Lo push Lhe fllled bodles up lnLo Lhe caps for
closure and Lo push Lhe closed capsules ouL of Lhe
bushlnasŦ
W Compressed alr also mav be used Lo e[ecL Lhe capsulesŦ
W 1he cap and bodv bushlna porLlons are re[olnedŦ
W Þlns are used Lo push Lhe fllled bodles up lnLo Lhe caps for
closure and Lo push Lhe closed capsules ouL of Lhe
bushlnasŦ
W Compressed alr also mav be used Lo e[ecL Lhe capsulesŦ
@ypes of Mach|nes Used @ypes of Mach|nes Used
5em|Ŵautomat|c 5em|Ŵautomat|c Iu||y Ŵautomat|c
W emlŴauLomaLlc machlnes
such as Lhe 1vpe 8 machlnes
(eŦaŦ Capsuael's Cap 8
machlne) requlre an operaLor
Lo be ln aLLendance aL all
LlmesŦ
W uependlna on Lhe sklll of Lhe
operaLorţ Lhe formulaLlonţ and
Lhe slze of Lhe capsule belna
fllledţ Lhese machlnes are
capable of fllllna as manv as
120ţ000Ÿ160ţ000 capsules ln
an 8Ŵhour shlfLŦ
W emlŴauLomaLlc machlnes
such as Lhe 1vpe 8 machlnes
(eŦaŦ Capsuael's Cap 8
machlne) requlre an operaLor
Lo be ln aLLendance aL all
LlmesŦ
W uependlna on Lhe sklll of Lhe
operaLorţ Lhe formulaLlonţ and
Lhe slze of Lhe capsule belna
fllledţ Lhese machlnes are
capable of fllllna as manv as
120ţ000Ÿ160ţ000 capsules ln
an 8Ŵhour shlfLŦ
W AuLomaLlc capsule fllllna
machlnes mav be classlfled as
elLher lnLermlLLenL or
conLlnuous moLlon machlnesŦ
W nterm|ttent mach|nes exhlblL
an lnLerrupLed fllllna sequence
as lndexlna LurnLables musL
sLop aL varlous sLaLlons Lo
execuLe Lhe baslc operaLlons
descrlbed aboveŦ
W Cont|nuous mot|on mach|nes
execuLe Lhese funcLlons ln a
conLlnuous cvcleŦ
W AuLomaLlc capsule fllllna
machlnes mav be classlfled as
elLher lnLermlLLenL or
conLlnuous moLlon machlnesŦ
W nterm|ttent mach|nes exhlblL
an lnLerrupLed fllllna sequence
as lndexlna LurnLables musL
sLop aL varlous sLaLlons Lo
execuLe Lhe baslc operaLlons
descrlbed aboveŦ
W Cont|nuous mot|on mach|nes
execuLe Lhese funcLlons ln a
conLlnuous cvcleŦ
Make/Mode| Dos|ng
pr|nc|p|e
Mot|on kated capac|ty
(capsu|es/hr)
osch
GkI 5
GkI 25
GkI
uoslna dlsc
lnLermlLLenL
lnLermlLLenL
lnLermlLLenL
24ţ000
130ţ000
180ţ000
MA
2anas| 6
2anas|
Mat|c 6
Mat|c 2
uosaLor
lnLermlLLenL
lnLermlLLenL
ConLlnuous
ConLlnuous
6ţ000
40ţ000
60ţ000
120ţ000
MG2
Iutura
G6
G2
uosaLor
ConLlnuous
ConLlnuous
ConLlnuous
48ţ000
60ţ000
120ţ000
@ab|eť 5e|ected Automat|c capsu|eŴf||||ng mach|nesť @ab|eť 5e|ected Automat|c capsu|eŴf||||ng mach|nesť
Þowder I||||ngť lollowlna equlpmenL and doslna meLhods
mav be ldenLlfled for powder fllllnať
Þowder I||||ngť lollowlna equlpmenL and doslna meLhods
mav be ldenLlfled for powder fllllnať
Ŧ Auger I|||
I|gŦ Capsu|e I||||ng w|th the
Auger Method
I|gŦ Capsu|e I||||ng w|th the
Auger Method
W Capsule fllllna uslna Lhe auaer prlnclple
ls Lhe oldesL semlŴauLomaLlc fllllna
LechnlqueŦ
W 1he aeneral fllllna prlnclple ls lllusLraLed
ln llaure bv Capsuael Lvpe 8 machlnesŦ
W 1he powder or aranules are conLalned
ln a hopper slmllar ln deslan Lo massŴ
flow hoppersŦ lnslde Lhese ls a roLaLlna
auaer Lo whlch a sLlrrer ls aLLachedŦ
W Þowder ls fed conLlnuouslv ouL of Lhe
hopper ouLleL owlna Lo Lhe roLaLlon of
Lhe auaer lnLo Lhe capsule bodlesŦ
W Capsule fllllna uslna Lhe auaer prlnclple
ls Lhe oldesL semlŴauLomaLlc fllllna
LechnlqueŦ
W 1he aeneral fllllna prlnclple ls lllusLraLed
ln llaure bv Capsuael Lvpe 8 machlnesŦ
W 1he powder or aranules are conLalned
ln a hopper slmllar ln deslan Lo massŴ
flow hoppersŦ lnslde Lhese ls a roLaLlna
auaer Lo whlch a sLlrrer ls aLLachedŦ
W Þowder ls fed conLlnuouslv ouL of Lhe
hopper ouLleL owlna Lo Lhe roLaLlon of
Lhe auaer lnLo Lhe capsule bodlesŦ
llaŦ uouble crew Auaer used ln Lhe Llqlll
uper
Machlnes
W 1he empLv capsule bodles are placed lnLo Lhe bushlnas of a
roLaLlna LurnLable ( plck up rlna) and wlll pass Lhe hopper
ouLleL durlna Lhe roLaLlon processŦ
W 1he empLv capsule bodles are placed lnLo Lhe bushlnas of a
roLaLlna LurnLable ( plck up rlna) and wlll pass Lhe hopper
ouLleL durlna Lhe roLaLlon processŦ
a) andwlch of cap and bodv rlnas
poslLloned under recLlfler Lo recelve
empLv capsulesŦ Iacuum ls pulled
from beneaLh Lhe rlnas Lo separaLe
caps from bodlesŦ
b) 8odv rlna s poslLloned under
fooL of powder hopper for
fllllnaŦ
c)AfLer fllllna Lhe bodlesţ Lhe cap and
bodv rlnas are re[olned and
poslLloned ln fronL of peasŦ A sLop
plaLe ls swuna down ln back of rlnas
Lo prevenL capsule expulslon as Lhe
pneumaLlcallv drlven peas push Lhe
bodles Lo enaaae Lhe capsŦ
d) 1he plaLe ls swuna aslde and Lhe
peas are used Lo e[ecL Lhe closed
capsulesŦ
W 1he flll of Lhe capsules ls prlmarllv volumeLrlcŦ 1he amounL of powder fed
dlrecLlv lnLo Lhe capsule bodv depends on Lheť
Llme Lhe capsule bodv spends underneaLh Lhe hopper ouLleLţ
capsule slzeţ
on Lhe auaer speed and
on Lhe LwlsL anale of Lhe auaerŦ
W lower roLaLlon of Lhe LurnLable lncreases Lhe flll welahLţ because Lhe
capsule bodles remaln underneaLh Lhe hopper ouLleL for a lonaer Llme
spanŦ An lncrease ln Lhe auaer speed and a sLeeper LwlsL anale wlll also
lncrease powder flll welahLŦ
O G||dantsť such as co||o|da| s|||ca lmprove Lhe flow properLles of Lhe
powder blend from Lhe hopper and Lhev also assure a unlform flow
raLe from Lhe hopperŦ 1he presence of Ʒ ta|c reduces welahL
varlaLlon compared Lo 0Ʒ LalcŦ
W ubr|cantsť such as magnes|um stearate and stear|c ac|d faclllLaLe Lhe
passaae of Lhe fllllna rlna under Lhe fooL of Lhe powder hopper and
help prevenLlna Lhe adherence of cerLaln maLerlals Lo Lhe auaer
O G||dantsť such as co||o|da| s|||ca lmprove Lhe flow properLles of Lhe
powder blend from Lhe hopper and Lhev also assure a unlform flow
raLe from Lhe hopperŦ 1he presence of Ʒ ta|c reduces welahL
varlaLlon compared Lo 0Ʒ LalcŦ
W ubr|cantsť such as magnes|um stearate and stear|c ac|d faclllLaLe Lhe
passaae of Lhe fllllna rlna under Lhe fooL of Lhe powder hopper and
help prevenLlna Lhe adherence of cerLaln maLerlals Lo Lhe auaer
2Ŧ V|bratory f||| pr|nc|p|eť
O IlbraLlonŴasslsLed fllllna ls a meLhod lnLroduced ln 1960 bv Lhe Csaka
Companv (!apan)Ŧ
O llaure lllusLraLes Lhe lndlvldual sLeps of Lhe fllllna procedureŦ
O IlbraLlonŴasslsLed fllllna ls a meLhod lnLroduced ln 1960 bv Lhe Csaka
Companv (!apan)Ŧ
O llaure lllusLraLes Lhe lndlvldual sLeps of Lhe fllllna procedureŦ
W 1he powder ls dlrecLlv fllled lnLo Lhe capsule bodlesŦ
W 1he capsule bodles are aaaln poslLloned lnLo a roLaLlna
LurnLable and pass underneaLh Lhe powder bowlŦ
W 1he powder bowl has a mesh floor connecLed Lo a
mechanlcal vlbraLorŦ Þowder or aranules pass Lhe mesh floor
wherebv Lhe vlbraLlon asslsLs wlLh desaaalomeraLlon and
flowŦ
W 1he capsule bodles are fllled Lo Lhe maxlmum exLenL plus
more powder on Lopţ fllllna Lhe cavlLles of Lhe LurnLable
compleLelvŦ
W lurLher roLaLlon aL Lhe LurnLable poslLlons Lhe capsule bodles
so LhaL a sprlnaŴloaded plunaer can compress Lhe powder
lnslde Lhe doslna bores Lo a more or less flrm pluaŦ A flxed
counLer plaLe underneaLh Lhe LurnLable asslsLs wlLh LhlsŦ
W 1he powder ls dlrecLlv fllled lnLo Lhe capsule bodlesŦ
W 1he capsule bodles are aaaln poslLloned lnLo a roLaLlna
LurnLable and pass underneaLh Lhe powder bowlŦ
W 1he powder bowl has a mesh floor connecLed Lo a
mechanlcal vlbraLorŦ Þowder or aranules pass Lhe mesh floor
wherebv Lhe vlbraLlon asslsLs wlLh desaaalomeraLlon and
flowŦ
W 1he capsule bodles are fllled Lo Lhe maxlmum exLenL plus
more powder on Lopţ fllllna Lhe cavlLles of Lhe LurnLable
compleLelvŦ
W lurLher roLaLlon aL Lhe LurnLable poslLlons Lhe capsule bodles
so LhaL a sprlnaŴloaded plunaer can compress Lhe powder
lnslde Lhe doslna bores Lo a more or less flrm pluaŦ A flxed
counLer plaLe underneaLh Lhe LurnLable asslsLs wlLh LhlsŦ
W 1he capsule bodv now conLalns a powder plua usuallv
conslderablv lonaer Lhan Lhe slze of Lhe bodv lLselfŦ
W 1he compleLe capsule bodv ls now pushed upwards so LhaL Lhe
powder plua s parLlallv ouLslde Lhe LurnLable boresŦ
W A scraper removes Lhe powder ouLslde Lhe LurnLable bores and
Lhe capsule bodles are pushed furLher upwards Lo be [olned Lo Lhe
correspondlna cap and dosedŦ
W 1he flnal flll welahL ls hence ad[usLable vla Lhe followlna
mechanlsmsť
roLaLlon speed of Lhe LurnLable and exLenL of vlbraLlon
compresslon seLLlna of Lhe plunaer
llnal plua lenaLh deflned bv Lhe amounL of llfL and Lhe acLlon
of Lhe scraperŦ
W 1he capsule bodv now conLalns a powder plua usuallv
conslderablv lonaer Lhan Lhe slze of Lhe bodv lLselfŦ
W 1he compleLe capsule bodv ls now pushed upwards so LhaL Lhe
powder plua s parLlallv ouLslde Lhe LurnLable boresŦ
W A scraper removes Lhe powder ouLslde Lhe LurnLable bores and
Lhe capsule bodles are pushed furLher upwards Lo be [olned Lo Lhe
correspondlna cap and dosedŦ
W 1he flnal flll welahL ls hence ad[usLable vla Lhe followlna
mechanlsmsť
roLaLlon speed of Lhe LurnLable and exLenL of vlbraLlon
compresslon seLLlna of Lhe plunaer
llnal plua lenaLh deflned bv Lhe amounL of llfL and Lhe acLlon
of Lhe scraperŦ
W 1hls svsLem works well for denseţ freeŴflowlna powdersŦ
W 1he svsLem ls commerclallv avallable as Llqfll
super
40 (hlonoal Cuallcapsţ !apan)ţ
produclna up Lo 40 000 capsules per hourŦ
W All slzes beLween 00 and 3 can be fllled excepL for nonŴsLandard capsulesŦ
W 1hls svsLem works well for denseţ freeŴflowlna powdersŦ
W 1he svsLem ls commerclallv avallable as Llqfll
super
40 (hlonoal Cuallcapsţ !apan)ţ
produclna up Lo 40 000 capsules per hourŦ
W All slzes beLween 00 and 3 can be fllled excepL for nonŴsLandard capsulesŦ
ÞlsLon Lamp Þrlnclple
W 1hese are fullv auLomaLlc flllers ln whlch plsLons or Lamplna plns llahLlv
compress Lhe lndlvldual doses of powders lnLo pluas (someLlmes referred
Lo as ºsluas") and e[ecL Lhe pluas lnLo Lhe empLv capsule bodlesŦ
W 1he powder ls Lamped lnLo Lhe doslna bores bv compresslon plns
(Lamplna flnaers)
W 1he Lamplna ls repeaLed flve Llmes Lo flrm an lndlvldual powder plua and
aL Lhe slxLh Lamplna evenLţ Lhe flnal plua ls pushed lnLo Lhe capsule bodvŦ
W 1o avold Lhe powder belna pushed Lhrouah Lhe doslna boresţ Lhe doslna
dlsc roLaLes over a brass supporL rlna (Lamplna rlna)
W 1hese are fullv auLomaLlc flllers ln whlch plsLons or Lamplna plns llahLlv
compress Lhe lndlvldual doses of powders lnLo pluas (someLlmes referred
Lo as ºsluas") and e[ecL Lhe pluas lnLo Lhe empLv capsule bodlesŦ
W 1he powder ls Lamped lnLo Lhe doslna bores bv compresslon plns
(Lamplna flnaers)
W 1he Lamplna ls repeaLed flve Llmes Lo flrm an lndlvldual powder plua and
aL Lhe slxLh Lamplna evenLţ Lhe flnal plua ls pushed lnLo Lhe capsule bodvŦ
W 1o avold Lhe powder belna pushed Lhrouah Lhe doslna boresţ Lhe doslna
dlsc roLaLes over a brass supporL rlna (Lamplna rlna)
1here are Lwo Lvpes of plsLon Lamp prlnclplesť 1here are Lwo Lvpes of plsLon Lamp prlnclplesť
1Ŧ uoslna ulsc Machlnes
2Ŧ uosaLor nozzle Machlnes
1Ŧ uoslna ulsc Machlnes
2Ŧ uosaLor nozzle Machlnes
1Ŧ uoslna ulsc machlnesť
llať @ampŴI||||ng Mechan|sm of Dos|ng D|sc Mach|neť 1he flve Lamplna
sLaLlons plus Lransfer sLaLlon are poslLloned on a clrcular paLh
llaŦ lnLermlLLenL uosaLor nozzle lllllna Þrlnclple
2Ŧ uosaLor nozzzle machlnesť
W 1he powder ls fed vla a
powder hopper lnLo Lhe
doslna hopper whlch roLaLes
and a meLal plaLe poslLloned
behlnd Lhe hopper ouLleL
lnslde Lhe doslna hopper
conLrols Lhe powder bed
helahLŦ
W 1he dosaLors are llned ln
palrs for Lhelr operaLlonŦ
W A dosaLor nozzle conslsLs of
a hollow doslna Lubeţ lnslde
whlch ls a movable plsLonŦ
W 1he powder ls fed vla a
powder hopper lnLo Lhe
doslna hopper whlch roLaLes
and a meLal plaLe poslLloned
behlnd Lhe hopper ouLleL
lnslde Lhe doslna hopper
conLrols Lhe powder bed
helahLŦ
W 1he dosaLors are llned ln
palrs for Lhelr operaLlonŦ
W A dosaLor nozzle conslsLs of
a hollow doslna Lubeţ lnslde
whlch ls a movable plsLonŦ
W 1he lnlLlal poslLlon of Lhe plsLon lnslde Lhe Lube deflnes Lhe
volume and consequenLlv Lhe welahL of Lhe powder plua Lo be
formedŦ
W 1he dosaLor nozzle ls lowered lnLo Lhe powder bed and Lhe
powder enLers lnLo Lhe doslna Lube and ls compressedŦ
W 1he dosaLor nlozzle ls Lhen llfLed up from Lhe powder bowlŦ
W AL Lhe same Llmeţ Lhe powder nozzle ls poslLloned over Lhe
capsule bodv and Lhe powder plua ls pushed ouL of Lhe doslna
Lube bv Lhe plsLon belna moved down Lo Lhe end of Lhe Lube
W AfLer Lhe nozzles have been llfLedţ Lhev swap poslLlon so LhaL
Lhe newlv formed plua can be released lnLo a new capsule bodv
and aL Lhe same Llme Lhe second nozzle ls lowered lnLo Lhe
powder bedŦ
W 1he lnlLlal poslLlon of Lhe plsLon lnslde Lhe Lube deflnes Lhe
volume and consequenLlv Lhe welahL of Lhe powder plua Lo be
formedŦ
W 1he dosaLor nozzle ls lowered lnLo Lhe powder bed and Lhe
powder enLers lnLo Lhe doslna Lube and ls compressedŦ
W 1he dosaLor nlozzle ls Lhen llfLed up from Lhe powder bowlŦ
W AL Lhe same Llmeţ Lhe powder nozzle ls poslLloned over Lhe
capsule bodv and Lhe powder plua ls pushed ouL of Lhe doslna
Lube bv Lhe plsLon belna moved down Lo Lhe end of Lhe Lube
W AfLer Lhe nozzles have been llfLedţ Lhev swap poslLlon so LhaL
Lhe newlv formed plua can be released lnLo a new capsule bodv
and aL Lhe same Llme Lhe second nozzle ls lowered lnLo Lhe
powder bedŦ
llaŦ Ilew of Lhe roLarv doslna unlL of C140
ConLlnous uosaLor nozzle CapsuleŴlllllna
Machlne
llaŦ Zanasl MaLlc 90 auLomaLlc capsuleŴfllllna machlne
MC2 luLura AuLomaLlc Capsule lllllna Machlne
IacuumŴlllllna MeLhod
W 1he vacuum meLhod ls based on a conLlnuous dosaLor nozzle prlnclpleŦ
W 1he movlna plsLon has been replaced bv a plsLon flLLed wlLh a porous
plaLe aL Lhe power endŦ lLs poslLlon remaln flxed durlna Lhe compleLe
fllllna processŦ
W 1he upper end of Lhe doslna Lube ls connecLed Lo an alrflow svsLemŦ
W When Lhe nozzle ls dlpped lnLo Lhe powder bedţ powder ls sucked lnLo
Lhe cavlLv formed bv doslna Lube and plsLon plaLeŦ
W When Lhe nozzle ls poslLlon over Lhe capsule bodvţ Lhe sucLlon ls
revered lnLo a mlld alr blowţ whlch Lransfers Lhe powder lnLo Lhe
capsule bodvŦ
W Þowder fllled wlLh Lhls mechanlsm ls less denslfledţ verv small doses can
be fllled and owlna Lo Lhe facL LhaL Lhere are no movlna parLs lnslde Lhe
doslna Lubeţ Lhe need for a lubrlcanL ln Lhe formulaLlon ls llmlLed and
ofLen no lubrlcanL ls requlredŦ
W 1hls makes such a svsLem ldeal for fllllna low doses and lnhalaLlonal
producLsŦ
W 1he vacuum meLhod ls based on a conLlnuous dosaLor nozzle prlnclpleŦ
W 1he movlna plsLon has been replaced bv a plsLon flLLed wlLh a porous
plaLe aL Lhe power endŦ lLs poslLlon remaln flxed durlna Lhe compleLe
fllllna processŦ
W 1he upper end of Lhe doslna Lube ls connecLed Lo an alrflow svsLemŦ
W When Lhe nozzle ls dlpped lnLo Lhe powder bedţ powder ls sucked lnLo
Lhe cavlLv formed bv doslna Lube and plsLon plaLeŦ
W When Lhe nozzle ls poslLlon over Lhe capsule bodvţ Lhe sucLlon ls
revered lnLo a mlld alr blowţ whlch Lransfers Lhe powder lnLo Lhe
capsule bodvŦ
W Þowder fllled wlLh Lhls mechanlsm ls less denslfledţ verv small doses can
be fllled and owlna Lo Lhe facL LhaL Lhere are no movlna parLs lnslde Lhe
doslna Lubeţ Lhe need for a lubrlcanL ln Lhe formulaLlon ls llmlLed and
ofLen no lubrlcanL ls requlredŦ
W 1hls makes such a svsLem ldeal for fllllna low doses and lnhalaLlonal
producLsŦ
llaŦ ť Iacuum asslsLed fllllna of Pard aelaLln capsules llaŦ ť Iacuum asslsLed fllllna of Pard aelaLln capsules
lllllna of pelleLsť
W lllllna of pelleLs ln Lo hard capsules requlres separaLe Lechnlques
from Lhose used for powders and aranulesţ because pelleLs are
laraer ln slze and cannoL be compressed and ofLen Lhev are coaLed
wlLh a fllm Lo conLrol drua releaseŦ
W ln Lhe flrsL sLepţ pelleLs flow form Lhe pelleL maaazlne lnLo Lhe
doslna chamberŦ
W 1he slze of Lhe doslna chamber can be varled bv movlna Lhe lefL
chamber sllde closer or furLher aparL form Lhe rlahL wall of Lhe
doslna chamberŦ
W 1he doslna sllde ls Lhen moved Lo Lhe lefL wherebv lL closes Lhe
doslna chamber from Lhe pelleL maaazlneŦ
W AL Lhe same Llmeţ Lhe ouLleL moves Lo Lhe rlahLţ and opens Lhe
doslna chamber aL Lhe boLLom endţ so LhaL Lhe pelleLs can flow
Lhrouah Lhe conlcal ouLleL lnLo Lhe capsule bodvŦ
W 8everslna Lhe movlna of Lhe doslna and Lhe ouLleL sllde sLarLs a
new fllllna cvcleŦ
W lllllna of pelleLs ln Lo hard capsules requlres separaLe Lechnlques
from Lhose used for powders and aranulesţ because pelleLs are
laraer ln slze and cannoL be compressed and ofLen Lhev are coaLed
wlLh a fllm Lo conLrol drua releaseŦ
W ln Lhe flrsL sLepţ pelleLs flow form Lhe pelleL maaazlne lnLo Lhe
doslna chamberŦ
W 1he slze of Lhe doslna chamber can be varled bv movlna Lhe lefL
chamber sllde closer or furLher aparL form Lhe rlahL wall of Lhe
doslna chamberŦ
W 1he doslna sllde ls Lhen moved Lo Lhe lefL wherebv lL closes Lhe
doslna chamber from Lhe pelleL maaazlneŦ
W AL Lhe same Llmeţ Lhe ouLleL moves Lo Lhe rlahLţ and opens Lhe
doslna chamber aL Lhe boLLom endţ so LhaL Lhe pelleLs can flow
Lhrouah Lhe conlcal ouLleL lnLo Lhe capsule bodvŦ
W 8everslna Lhe movlna of Lhe doslna and Lhe ouLleL sllde sLarLs a
new fllllna cvcleŦ
llať lllllna of pelleLs wlLh double sllde mechanlsm llať lllllna of pelleLs wlLh double sllde mechanlsm
llaŦ lllllna of ÞelleLs wlLh modlfvlna doslna dlsc svsLem llaŦ lllllna of ÞelleLs wlLh modlfvlna doslna dlsc svsLem
llaŦ lllllna of pelleLs wlLh vacuum asslsLed dosaLor nozzle svsLem
8LlL8LnCLť
1 . Podczeck Fridrun and Jones E Brian , Pharmaceutical capsules 2
nd
edition ,
Pharmaceutical Press, Page no. 119-137
2. Banker Gilbert S. and Rhodes Christopher T. , Modern Pharmaceutics, 4
th
edition,
Marcel Dekker, Page no. 347-356
1 . Podczeck Fridrun and Jones E Brian , Pharmaceutical capsules 2
nd
edition ,
Pharmaceutical Press, Page no. 119-137
2. Banker Gilbert S. and Rhodes Christopher T. , Modern Pharmaceutics, 4
th
edition,
Marcel Dekker, Page no. 347-356

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