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LifePak

Technical Training for Medical Representative Certification


Written by:

Carsten R. Smidt, Ph.D., F.A.C.N.

The LifePak Family

The LifePak Family

Study Materials
Copy of these slides Draft, LifePak Monograph
For internal use only. Do not copy!

Nutrition 101
Present Knowledge in Nutrition
Seventh Edition E. E. Ziegler and L. J. Filer, Jr. 1996, 684 pages, $50.00 ILSI Press, 202-659-0074 x123 ilsipress@ilsi.org

Dont fall asleep!


Possible Exam Items:

What you will learn:


y y y

Why take multivitamins? Concept of optimum supplementation LifePaks 5-in-1 concept


antioxidants, free radicals & heart health B-vitamins & homocysteine bone nutrients & osteoporosis trace elements & bioavailability phytonutrients

What you will learn:


y

y y y y

LifePak & Cardiovascular Health, Glucose & Insulin Metabolism, and Immune Function Key features of other LifePak products LifePak Directions LifePak Safety LifePak Precautions

In other words...

LifePak is the best multivitamin/mineral supplement -worldwide!

Why take multivitamins?


y

To meet the RDAs, I.e., prevent nutrient deficiencies To improve general well-being, e.g., physical and mental performance To stay healthy (health insurance in pill form)

Multivitamin Usage

38 % of US population are regular multivitamin users! What shall we do with the other 62 %?

Recommended Dietary Allowances


RDA Definition: Intake level of essential nutrients judged to be adequate to meet the needs of practically all healthy persons. RDAs prevent classical deficiency diseases:
Vitamin C & Scurvy Thiamin & Beri-Beri

RDAs have a safety margin: Less than 2/3rds of RDA = nutrient deficiency

RDA, RDI, DV confusing?


RDA: Recommended Dietary Allowances, NRC Food and Nutrition Board 1989. NRC Food and Nutrition Board 1998-? RDI: Recommended Daily Intake, FDA, for labeling, based on 1978 RDAs. % DV: Daily Value, FDA, % of RDI present in a serving of a food or supplement.

Why take multivitamins?


In a survey of 21,500 people*, not a single person consumed a 100% of RDA for the 10 most important nutrients! Over 70% of people did not even meet 2/3rds of RDA for one or more nutrients.**
* USDA National Food Consumption Survey 1977-78. ** USDA National Food Consumption Survey 1987-88.

Vi ta

10

20

30

40

50

60

70

80

90

0
A E C

Vi ta Vi ta m in am R in ib of la vi n N ia Vi ci n ta m in B6 Fo Vi la ta m te in B1 Ca 2 lc M i ag um ne si um Iro n Zi n c Th i m in

m in

Percent of Adults Not Meeting RDA

Males

Females

Source: USDA 1994-96 CSFII

Eat More Fruits & Vegetables!

Eat Fruits & Vegetables!


National Cancer Institute: Eat 5-10 servings to prevent cancer! 90% of Americans eat less than 5 servings a day.* U.S. average is 3.2 servings/day.* Fruits & vegetables contain vitamins, minerals, thousands of phytonutrients, dietary fiber and potassium.
*NHANES II data

Are RDAs adequate?


RDAs do not consider optimum intakes.
Vitamin E: 100-400 IU Vitamin C: 200-500 mg Chromium: 200 mcg

Optimum RDAs are under development by the NRC Food and Nutrition Board (NRC FNB)

Optimum Supplementation
Ensures RDA levels + Considers typical dietary intakes + Optimum nutrient levels for long-term health + Non-essential, beneficial nutrients

What is LifePak?
LifePak is a comprehensive nutritional supplementation program delivering the optimal amounts of all essential vitamins, antioxidants, minerals, and trace elements, as well as beneficial phytonutrients.

LifePak 5-in-1 Concept


LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

What are Free Radicals?


Free radicals are highly reactive, short-lived compounds that can destroy the bodys fats, proteins and nucleic acids (DNA). Free radicals are involved in the etiology of:
cardiovascular disease cancer cataract, macular degeneration aging process

What are Free Radicals?


There are many types of free radicals...
HO hydroxyl radical, 10-9 seconds RO alkoxyl radical, 10-6 seconds ROO peroxyl radical, 7 seconds NO nitric oxide radical, 1-10 seconds O2- superoxide anion radical, enzymic

and reactive oxygen species (ROS):


1O2 singlet oxygen, 10-5 seconds ONOO- peroxinitrite, 0.05-1 seconds H2O2 hydrogen peroxide, enzymic

Free Radical Sources


Environmental pollution Radiation: UV light, X-ray, K-ray Smoking: 1016 free radicals/cigarette Normal oxidative metabolism of carbohydrates, fats & proteins for energy production.

Antioxidants
Capture/neutralize free radicals
(e.g., vitamin E in cell membranes, etc.)

Intrinsic Antioxidants:
albumin, uric acid, a-ox enzymes (GPX, SOD, catalase), and others.

Extrinsic (Dietary) Antioxidants:


a-ox vitamins, trace element cofactors, carotenoids, flavonoids, and others.

Antioxidant Effects
Decrease free radical damage (oxidation)
especially in people with high oxidative stress:
smokers, elderly, people in polluted urban areas

Improve cardiovascular health:


Reduce LDL-Oxidation & atherosclerosis

Slow down aging process:


Less DNA & protein damage

Help prevent cancer:


Protect DNA; promote normal cell growth

Antioxidants
Many types of antioxidants must work together (in synergy) to afford effective protection from free radical damage. Antioxidant defense system

LifePak Antioxidants
Vitamin C, 500 mg Vitamin E, 300 IU, natural Selenium, Zinc, Copper, Manganese alpha-Lipoic acid Phytonutrients:
Carotenoids Flavonoids

Objective of LifePak Studies


Does LifePak supplementation improve antioxidant status and decrease LDLoxidation in healthy non-smokers consuming typical U.S. diets?

LifePak Antioxidant Studies


Two double-blind studies (FDA-GCP):
140-subject parallel design (Houston, TX) 46-subject cross-over design (Evansville, IN) LifePak or placebo for 6 weeks Both studies evaluated antioxidant status and LDL oxidizability.

FASEB J. 13(4): A546 (cross-over study) other publications forthcoming.

LifePak Antioxidant Studies


Inclusion/Exclusion Criteria for Subjects: y healthy non-smokers y men & women, ages 18-65 y on typical U.S. Diets
< 5 servings of fruits & vegetables per day
y

no other dietary supplements or medications

Serum F-Carotene
(nmol/L)
1200 1000 800 600 400 200 0 Baseline Endpoint
331
335 716

PL MVMS

(means +/- SD) p < 0.001

299

Serum E-Carotene
(nmol/L)
1000 800 600
592

PL MVMS

(means +/- SD) p < 0.001

400 200
122

77

85

Baseline

Endpoint

Serum Vitamin C
(Qmol/L)
140 120 100 80 60 40 20 0 Baseline Endpoint
67.4 68.1 70.6 94.3

PL MVMS

p < 0.001 (means +/- SD)

Serum Vitamin E
(Qmol/L)
50 40 30 20
19.9 20 20.6 36.9

PL MVMS

(means +/- SD)

p < 0.001

10 0 Baseline Endpoint

Serum Selenium
(Qmol/L)
4 PL MVMS 3
2.3
2.5

(means +/- SD)

p < 0.01

2.2

2.1

0 Baseline Endpoint

LDL Oxidation
y

LDL are prone to oxidation by free radicals. Oxidized LDL tend to adhere to artery walls more than non-oxidized LDL. Antioxidants can improve LDLs resistance against free-radical oxidation

Blood Sample Plasma LDL isolation LDL

LDL Oxidizability

LDL

Copper Ion Solution

LDL

LDL

LDL Oxidizability

Oxidation

Rate Lag Time Time

LDL Oxidizability, lag time


(min)
60 50
50.9

PL MVMS

(means +/- SD)

p < 0.001

40 30 20 10 0

42.1

43.4

42

Baseline

Endpoint

LDL Oxidizability, Rate


(Qmol/min x g protein)
20 18 16 14 12 10 8 6 4 2 0 Baseline Endpoint
12.7
12.5

PL MVMS

(means +/- SD) p < 0.001


12.9
11.4

LP Studies: Conclusions
LifePak improved antioxidant status. LifePak increased LDLs resistance against free-radical oxidation, and thus, may have cardiovascular benefits. LifePak is safe and well-tolerated.

LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

LifePak B-Vitamins
Balanced accdg. to optimum requirements. Optimum amounts for normal homocysteine metabolism.
Homocysteine: Undesirable amino acid byproduct from methionine metabolism impairs vascular function, atherogenic independent risk factor for cardiovascular disease B12, Folate & B6 help control homocysteine.

LifePak B-Vitamins
Regular LifePak B-Vitamins:
Thiamin (vitamin B1) Riboflavin (vitamin B2) Niacin Vitamin B6 (pyridoxine) Folic Acid Vitamin B12 Pantothenic Acid Biotin 3 mg 3.4 mg 40 mg 10 mg 600 mcg 30 mcg 30 mg 300 mcg 200 % DV 200 % DV 200 % DV 500 % DV 150 % DV 500 % DV 300 % DV 100 % DV

LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

Bone Nutrition: Calcium


y

y y y

Calcium (Ca) is the major bone mineral, and it helps prevent osteoporosis. Calcium intake: 55% of men and 78% of women do not meet the RDA! Calcium RDA = RDI (DV): 1,000 mg/day 1 gl. of milk = 300 mg calcium = 30 % DV LifePak has 500 mg Ca = 50 % DV

Bone Nutrition

Calcium alone is not the answer!

LifePak Bone Nutrients


Magnesium: Like Ca, a structural component y 60 % of bodys Mg is in bone y Mg supplementation increases BMD y Mg also promotes heart rhythm, blood pressure and muscle function (ATP action). y Mg intake: 66% of men and 76% of women do not meet the RDA! y LifePak: 250 mg Mg = 62.5 % DV

LifePak Bone Nutrients


Vitamin D: Fat-soluble vitamin y helps regulate Ca, Mg, and bone metabolism y functions as a hormone y Deficiency is common y Experts recommend supplementation with 400 IU daily from multivitamins y All LifePaks have 400 IU vitamin D

LifePak Bone Nutrients


Vitamin K: Fat-soluble vitamin promotes Ca incorporation into bone Boron and Silicon: trace elements support normal bone metabolism Soy Isoflavones (Phytoestrogens): promote bone mineralization

LifePak Bone Nutrients


Calcium Magnesium Vitamin D Vitamin K Boron Silicon Soy Isoflavones 500 mg 250 mg 400 IU 40 mcg 3 mg 3 mg 10 mg 50 % DV 62.5 % DV 100 % DV 50 % DV n/a n/a n/a

LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

LifePak Trace Elements


Key Features: Highly bioavailable (utilized by the body) Excellent tolerance Complete spectrum at optimum amounts

LifePak Trace Elements


Top Quality Sources (Amino Acid Chelates, Albion Labs, etc.) Zinc AA Chelate Iron AA Chelate Copper AA Chelate Iodine (iodide) Vanadium (sulfate) Selenium (SeMet, selenite)

Chromium AA Chelate Manganese AA Chelate Molybdenum AA Chelate Silicon (metasilicate) Boron (citrate)

LifePak Trace Elements


Highlights: Chromium (200 mcg):
normal insulin and blood glucose levels 90 % of US diets may be low in chromium effective in non-insulin-dependent diabetes

Selenium (100 mcg):


essential cofactor for glutathione peroxidase, an antioxidant enzyme may prevent prostate cancer

Chelates & Bioavailability


Bioavailability = the bodys ability to utilize a nutrient = absorption + tissue uptake + metabolic functions. Amino acid chelates tend to have the highest bioavailability and solubility of all mineral forms. Amino acid chelates are often better tolerated than inorganic mineral salts.

Chelates & Bioavailability


Chelates { Amino Acid Chelates
Pseudo-chelates: mixtures of mineral salts and hydrolyzed proteins; proteinates etc. LifePak: covalently-bound, fully reacted amino acid chelates (Albion Laboratories)
H 2C O=C O H 2N CH2 NH2 O M C=O

LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula

Phytonutrients
A.k.a. phytochemicals or secondary plant metabolites. Non-essential plant compounds with health benefits. Over 12,000 phytonutrients have been isolated from foods.

LifePak Phytonutrients
LifePak provides a broad spectrum of:

Carotenoids Flavonoids (Polyphenols)

LifePak Phytonutrients
Carotenoids:
y y y y y y

over 600 carotenoids present in nature safe vitamin A sources (a- & b-carotene) fat-soluble antioxidants (1O2 quenchers) promote immune function (b-carotene) prevent prostate cancer (lycopene) prevent macular degeneration (lutein)

Phytonutrients
Beta-Carotene: Friend or Foe?
y

high-dose (20-30 mg) synthetic beta-carotene may promote existing lung tumors (ATBC study, CARET study). Population studies: beta-carotene decreases risk for most cancers, incl. lung cancer. Other carotenoids have been ignored in research. Most are more potent antioxidants.

Phytonutrients
Beta-Carotene: Friend or Foe?
Recommendations: y Eat more fruits & vegetables! y Pharmanex - IDN position: Supplementation is beneficial:
y with a broad spectrum of dietary carotenoids y at physiologic levels y reflecting carotenoids from fruits & vegetables

LifePak Phytonutrients
LifePak Carotenoids:
beta-Carotene (D.salina) 6 mg (10,000 IU) lutein (Marigold extract) 2 mg lycopene (Tomato extract) 1 mg alpha-Carotene 2 mg Zeaxanthin beta-Cryptoxanthin (extracts conform to Pharmanex 6S Process)

LifePak Phytonutrients
Flavonoids:
y O

y y y y

over 5,000 flavonoids known in nature, 600 present in our diets. water/alcohol soluble plant products powerful antioxidants many enhance microcirculation (blood flow) many appear to prevent cancer (epidemiological, animal studies)

LifePak Phytonutrients
LifePak Flavonoids (145 mg total):
y

From 5 well-researched stdzd. extracts:


y y y y y OPC from grape seed extract Hesperidin & Naringenin from citrus extract Quercetin Isoflavones (genistein, etc.) from soy extract Curcumin (polyphenols) from turmeric extract

y y

Amount } 5-10 servings of fruits & veggies All extracts conform to 6S Process

Synopsis: Health Benefits


LifePak: optimum supplementation for: y addressing common nutrient deficiencies y bone nutrition y cardiovascular health y glucose and insulin metabolism y immune function

LifePak & Cardiovascular Health


Antioxidants: lower LDL-oxidizability Calcium & Magnesium: maintain normal
blood pressure & heart rhythm

B-Vitamins: maintain normal blood homocysteine Flavonoids: promote normal platelet aggregation
and blood microcirculation

LifePak & Insulin/Glucose Metabolism


Vitamin C, 500 mg:
promotes normal sorbitol metabolism

Vitamin E, 300 IU:


promotes normal platelet aggregation keeps protein glycosylation in balance

Chromium, 200 mcg:


essential for normal insulin function

LifePak & Immune Function


Promoting normal immune function

Vitamins C & E:
promotes cell-mediated specific and non-specific immunity

beta-Carotene, carotenoids:
promotes natural killer cell activity

Vitamin A, vitamin B6 & zinc:


essential for immune function

LifePak Women

LifePak Women
Young, Pre-Menopausal Women
Key Features:
Bone Nutrition: 1,000 mg calcium & 500 mg magnesium (2x LifePak!), & extra silicon;
National Insitutes of Health: 1,000 - 1,500 mg Ca/day About 80% of young women do not meet RDA (1,000 mg) FDA Health Claim: Calcium prevents osteoporosis

Extra Iron: 10 mg, amino acid chelate


iron deficiency is more common in young women; over 70% do not meet RDA!

LifePak Women
Key Features, continued
Folate and Inositol: For women in their childbearing years;
Folate prevents neural tube defects (FDA health claim)

Extra Vitamin B6: 20 mg


65 % of women dont meet the RDA for vitamin B6

Special Phytonutrients:
25 mg soy isoflavones: same as in 25 grams soy protein gamma-linolenic acid-rich oils.

LifePak Prime

LifePak Prime
For Post-Menopausal Women & Men Over Age 40
Key Features:
Bone Nutrition: 1,000 mg calcium & 500 mg magnesium (2x LifePak!), & extra silicon
NIH: 1,000 - 1,500 mg calcium per day

Extra Zinc: 20 mg amino acid chelate


zinc promotes healthy immune function over 85% of the elderly do not meet the RDA

LifePak Prime
Key Features, continued:
Glucosamine: 200 mg
promotes joint structure & function 200 mg doubles average dietary intake

Special Antioxidants: glutathione, N-acetylcysteine, coenzyme Q10 Extra Phytonutrients: More curcumin, grape seed OPCs; added stdzd. Ginkgo extract and Milk Thistle extract.

LifePak PreNatal

LifePak PreNatal
For Pregnant & Lactating Women
Key Features:
Optimum Antioxidants: 150 IU natural vitamin E & 300 mg buffered vitamin C
may prevent pre-eclampsia (gestational hypertension) pre-eclampsia affects 5-15 % of pregnant women

Bone Nutrition: 650 mg Calcium & 350 mg Magnesium


pregnancy: fetal bone growth lactation: milk production

LifePak PreNatal
Key Features, continued:
Folate and Inositol: 800 mcg, 500 mg
prevent neural tube defects

Extra Iron: 30 mg, Amino Acid Chelate


best tolerated and most bioavailable form of iron higher demands due to fetal blood & muscle formation high risk for iron deficiency anemia

Chromium: 180 mcg, Amino Acid Chelate


promotes normal insulin and blood glucose metabolism benefits in gestational diabetes mellitus

LifePak PreNatal
Key Features, continued:
Vitamin A: 5,000 IU is safe and effective
Supplementation with more than 10,000 IU of preformed vitamin A may increase the risk for fetal damage (teratogenic effects).

Carotenoids: Natural beta-carotene (5,000 IU), alpha-carotene, lutein & lycopene.

LifePak Teen Optimum Supplementation for 9-18 year olds

TM

THE PROBLEM: Over 60% of teen boys and over 80% of girls dont meet the RDA for calcium or magnesium*
*USDA CSFII 1994-96 Survey Data

THE SOLUTION: LifePak Teen Bone Nutrients: 500 mg Calcium 200 mg Magnesium 400 IU Vitamin D 40 mcg Vitamin K 3 mg Boron 3 mg Silicon

THE PROBLEM: THE SOLUTION: Not enough antioxidant vitamins: Over 60% of teens dont get the RDA for vitamins A & E*
*USDA CSFII 1994-96 Survey Data

LifePak Teen Antioxidants 5,000 IU Vitamin A 3 mg F-carotene 100 IU Vitamin E 200 mg Vitamin C 70 mcg Selenium

THE PROBLEM: THE SOLUTION: Not enough iron: 72.5% of girls ages 1219 dont meet the RDA for iron*
*USDA CSFII 1994-96 Survey Data

LifePak Teen 9 mg iron as amino acid chelate; 50% of Daily Value

THE PROBLEM: THE SOLUTION: Not enough zinc: Over 65% of teens dont meet the RDA for zinc*
*USDA CSFII 1994-96 Survey Data

LifePak Teen 15 mg zinc as amino acid chelate; 100% of Daily Value

LifePak Safety
y

All vitamin & mineral levels are below the NOAEL (No Observed Adverse Effect Level) established by the CRN (Council for Responsible Nutrition, 1998). Phytonutrients are added at levels that are documented safe. Clinical studies showed no adverse effects to LifePak

LifePak Directions
One packet twice daily with meals
meals enhance absorption (vitamins) and improve tolerance (minerals) twice daily promotes steady nutrient delivery, e.g., plasma levels of vitamin B6:

7:30 AM

6:30 PM

LifePak Precautions
Pregnant & lactating women, diabetics, hypoglycemics, and people with known medical conditions should consult with a physician before taking supplements

LifePak Substantiation
Over 1,000 peer-reviewed scientific papers on file documenting the efficacy and safety of all nutrients in LifePak.

LifePak Substantiation
No other complete multi-nutrient supplement has ever been subjected to two well-designed double-blind clinical studies to show antioxidant effects in healthy people.

In other words...

LifePak is the best multivitamin/mineral supplement -worldwide!