Calcium Metabolism, Vitamin D, Parathyroid Hormone and Calcitonin

Shibani Hegde-080201024 Riddhi Joshi-080201027

Skeletal muscle contraction 2.Smooth muscles contraction 4.Cardiac muscle contraction 3.Transmission of nerve impulses .Calcium-Importance • Key role played by calcium in: 1.Blood clotting 5.

Intracellular – 1% • 3.1% • 2. Bones – Rest (Serve as Reservoirs) • Calcium Distribution in ECF .0. ECF .Distribution of Calcium in the Body % distribution of total body calcium • 1.

Calcium Exchange Between Different Tissue Compartments 100 0 .

some amorphous) • Exchangeable calcium – readily mobilizable salts like calcium phosphate and other amorphous salts .Bone And Its Relation to Extracellular Calcium • Bone = matrix (collagen + ground substance) + salts (mostly hydroxyapetite.

Calcium regulation .

25 dihydroxy cholecalciferol {calcitriol} (kidney) – active component • increases calcium and phosphate levels • Bone : promotes absorption .Vitamin D • Skin: dehydrecholesterol converts to cholecalciferol • 25 hydroxy cholecalciferol {calcifediol} (liver) • 1.

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PTH • Activated when calcium is low in plasma • Increases calcium levels in blood • Bone : increases resorption • Kidney : increases absorption • Also enhances activation of Vit D in the kidney .

calcitonin • Activated when calcium is high in plasma • Antagonist of PTH • Decreases calcium levels in blood • Bone : decreases bone resorption • Intestine : decreases intestinal absorption .

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