ransfusion Reactio

In medicine, a transfusion reaction is any adverse event which occurs because of a blood transfusion.

form of an; •allergic reaction •transfusion-related infection •hemolysis related to an incompatible blood type •an alteration of the immune system related to the transfusion.

transfusion reaction must always be balanced against the anticipated benefit of a blood transfusion.

Types of Transfusion Reactions

Febrile non-hemolytic transfusion reaction. This is the most common adverse reaction to a blood transfusion. Symptoms include fever and dyspnea 1 to 6 hours after receiving the transfusion. Such reactions are clinically benign, causing no lasting side effects or problems, but are unpleasant. Risk is estimated, as of 2006, at 1 per 2 million units

Bacterial infection. Blood products can provide an excellent medium for bacterial growth, and can become contaminated after collection while they are being stored. The risk is highest with platelet transfusion, since platelets must be stored near room temperature and cannot be refrigerated.
The risk of severe bacterial infection and sepsis is estimated (2001) at about 1 in 50,000 platelet transfusions

Acute hemolytic reaction. This is a medical emergency resulting from rapid destruction (hemolysis) of the donor red blood cells by host antibodies. The most common cause is clerical error (i.e. the wrong unit of blood being given to the wrong patient). The symptoms are fever and chills, sometimes with back pain and pink or red urine (hemoglobinuria). The major complication is that

Anaphylactic reaction. An anaphylactic (or severe allergic) reaction can occur at a rate of 1 per 30,000-50,000 transfusions. These reactions are most common in people with selective IgA deficiency (although IgA deficiency is often asymptomatic, and people may not know they have it until an anaphylactic reaction occurs). An anaphylactic reaction is a

Transfusion-associated acute lung injury (TRALI). TRALI is a syndrome of acute respiratory distress, often associated with fever, noncardiogenic pulmonary edema, and hypotension. It may occur as often as 1 in 2000 transfusions. Symptoms can range from mild to lifethreatening, but most patients recover fully within 96 hours,

Volume overload. Patients with impaired cardiac function (eg congestive heart failure) can become volume-overloaded as a result of blood transfusion, leading to edema, dyspnea (shortness of breath), and orthopnea (shortness of breath while lying flat).
This is sometimes called TACO, or Transfusion Associated Circulatory

Iron overload. Each transfused unit of red blood cells contains approximately 250 mg of elemental iron. Since elimination pathways for iron are limited, a person receiving numerous red blood cell transfusions can develop iron overload, which can in turn damage the liver, heart, kidneys, and pancreas. The threshold at which iron overload becomes significant is somewhat unclear, but

Transfusion-associated graft-vs-host disease (GVHD). GVHD refers to an immune attack by transfused cells against the recipient. This is a very rare complication of blood transfusion. It occurs only in severely immunosuppressed patients, primarily those with congenital immune deficiencies or hematologic malignancies who are receiving intensive chemotherapy. When GVHD occurs in association with blood transfusion, it is almost uniformly fatal. Transfusion-associated GVHD can be


•Stop the transfusion immediately (saving the remaining blood and IV tubing for testing) and to provide supportive care to the patient. •More specific treatments depend on the nature and presumed cause of the transfusion reaction. Most hospitals and medical centers have transfusion reaction protocols, which specify testing of the blood product and patient for hemolysis, bacterial

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