Toxic Metals and Essential Elements in Hair and Severity of Symptoms among Children with Autism

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 .  Hair.The diagnoses of metal intoxication or a mineral/trace element deficiency can be assessed by : Blood.  Urine.

 . . The EPA stated that hair is “a meaningful and representative tissue” for measuring toxic metals and selected nutrients. and research suggests its usefulness as an early predictor of toxic exposure.  the National Health and Nutrition Evaluation Study continue to use hair as one method to evaluate levels of metals such as mercury. Hair mineral analysis is easy and painless.

 .  sample digestion.  Samples were repeatedly washed in the laboratory with a metal-free detergent. certified metal free acids were used.Tack hair samples close to the scalp from the occipital area for testing.  Rinsed 3 times with ultrapure water  Dried in a special drying oven before weighing.

closed-vessel  Ultrapure water was used for final sample dilution. a reliable new method for interference reduction.  . (ICP-MS) utilizing collision/reaction cell methods coupled with ion-molecule chemistry. Digestion took place in a microwave digestion system.  The elemental analysis was performed via inductively coupled plasma mass spectrometry.

• • • • • no dental mercury amalgam No previous use of DMSA No anemia No liver or kidney disease Children are well hydrated .

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045 0.7 .15 7.9 0.Metal &essential Mean value of all Mean value of control autistic hair test hair test Calcium(Ca) 43.07 0.37 7.1 110 – 227 0.68 5.3 .70 3.72 0.7 .115 0.02 67.04 o.98 200 – 850 Copper(Cu) Iron(Fe) Iodine(I) Lithium(Li) Magnesium Manganess Zinc Zn Selenium(Se) 133.38 0.55 0.03 6.5 20 .2 .0015 12.

nickel. Nutritive elements. . including calcium. magnesium. copper. and lead are more prevalent in the hair of children with autism as compared to age and sex matched healthy controls. iron. iodine. and selenium are more deficient Among autistic children. mercury. manganese. zinc.The potentially toxic elements chromium.

• Hair analysis is of potential usefulness for the determination of toxic and essential elements in ADS children. offering an early chance for intervention and treatment. Biological damage from toxic material and increased environmental exposure at key times in development may play a causal role in the etiology of autistic disorders and potentially increases the severity of autistic symptoms. .