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CURRENT STATUS OF VETERINARY VACCINES PRODUCTION IN VETERINARY RESEARCH INSTITUTE PESHAWAR

BY Dr. Nasir Hussain Shah Director, VRI, NWFP PESHAWAR

INSTITUTIONAL FACILITIES
Animal Vaccines are being produced in respective sections and laboratories. These are:

Media and sterilization Section Bacterial Vaccine section Viral Vaccine Section Standardization and Quality Control Section Vaccine Supply and Marketing Section. Center of Animal Biotechnology

INSTITUTIONAL FACILITIES
These laboratories are equipped with
necessary machinery and equipments which are performing up to the level of satisfaction, despite the fact that some of them are decades old.

INSTITUTIONAL FACILITIES
Various processes involved in vaccine production
and facilities available are as follows:
Media preparation and sterilization Vaccinal seed culture preparation and inoculation Incubation In process checking and testing Vaccine formulation Quality control testing Vaccine dispensing Vaccine supply and marketing

INSTITUTIONAL FACILITIES
An experimental laboratory animals colony
has been maintained for quality control tests of vaccines. Similarly cold storage facilities have been established for storage of vaccines at recommended temperature.

VACCINE BEING PRODUCED


VRI Peshawar is currently producing the
following vaccines.
1. 2. 3. 4. 5. 6. 7. 8. Haemorrhagic septicemia vaccine Black quarter disease Vaccine Enterotoxemia cum lamb dysentery vaccine Anthrax Spore Vaccine Newcastle Disease Vaccine Oil adjuvant Haemorrhagic Septicemia Vaccine Bird Flu Vaccine Foot and Mouth Disease Antiserum

TYPE OF PROTOCOL/METHODOLOGY
Almost all of the above vaccines are being
produced according to FAO /OIE protocol.

Quantity
Vaccines production is mostly demand oriented.
During the current year the following quantity of vaccines have been prepared.

HSV BQV ETV ASV NDV HSOAV Bird Flu Vaccine FMD Antiserum

= = = = = = = =

0.50 0.38 0.58 0.1 14.7 12945 26500 212

Million doses Million doses Million doses Million doses Million doses Doses Doses Doses

QUALITY CONTROL MECHANISM


Vaccines
are produced in sterilized environment adopting strict hygienic and bio safety measures. Various types of tests are routinely carried out right from manufacturing till finished product according to standard protocol of FAO / OIE.

TYPE OF ASSISTANCE REQUIRED


Assistance is required in the following areas.
Professional Trainings in new techniques in Vaccinology. Technical and financial assistance in construction of P-3 level Laboratories. Machinery and Equipment assistance. Separate building for vaccine production with well-equipped labs.

QUALITY CONTROL REQUIREMENTS

Specific trainings of technical staff in related techniques Well established Animal House

Well equipped laboratories

DNA VACCINES
Two main approaches are being used to
develop vaccines using recombinant DNA technology. The first involves deleting genes that determine the virulence of the pathogen, thus producing attenuated organisms (non-pathogen) that can be used as live vaccines.

DNA VACCINES
The second approach is to identify protein
subunits of pathogens that can stimulate immunity.

DNA VACCINES
Korean Scientists
have developed a combined vaccines against Pleuropneumonia, Pneumonic Pasteurellosis and enzootic Pneumonia in swine. In the Philippines, a vaccine has been developed that protects cattle and water buffalo against Haemorrhagic Septicaemia, which is the leading cause of death in these animals.

VACCINES AGAINST PARASITES


A novel strategy for developing vaccines against
blood sucking parasites involves using components of the gut wall of the parasite that are not normally exposed to the immune system of the host. When the parasite feeds, it ingests antibodies induced by the vaccines, which destroy the gut wall and, consequently, kill the parasite. This strategy has been used successfully to develop a vaccine against the one-host tick Boophilus microplus

THANKS