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Seminar on Liposomes in Drug Delivery

Seminar on Liposomes in Drug Delivery

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M.Pharm (Pharmaceutics) 2010-2011 Liposomes in Drug DeliveryMaliba Pharmacy College, Tarsadi Page 1
 Seminar on
 LIPOSOMES IN DRUGDELIVERy 
Presented By: -
 
Dobariya Jayesh P.M.Pharm Sem III (Pharmaceutics)Roll no. 04,Year : 2010-2011
 
Department of Pharmaceutics,
 
Maliba Pharmacy College, Tarsadi, Bardoli.
 
 
M.Pharm (Pharmaceutics) 2010-2011 Liposomes in Drug DeliveryMaliba Pharmacy College, Tarsadi Page 2
CONTENTS
 
1.
 
Introduction2.
 
Structural components3.
 
Advantages and Disadvantages4.
 
Types of Liposomes5.
 
Preparation of Liposomes- Handling of Liposomes- Drying of liposomes- Mechanism of liposomes preparation- Methods of preparation6.
 
Characterization of Liposomes7.
 
Pharmacokinetics of Liposome encapsulated drugs8.
 
Pharmacodynamics of Liposome encapsulated drugs9.
 
Stability of Liposomes10.
 
Applications of Liposomes11.
 
Recent advances12.
 
Liposome products in Market as well as in clinical trials13.
 
Conclusion14.
 
References
 
M.Pharm (Pharmaceutics) 2010-2011 Liposomes in Drug DeliveryMaliba Pharmacy College, Tarsadi Page 3
Number of carriers was utilized to carry drug at the target organ/tissue which includeimmunoglobulins, serum proteins, synthetic polymers, lipid vesicles (liposomes),microspheres, erythrocytes, reversed micelles, niosomes, pharmacosomes, etc.Among them, liposomes show strong potential for efficient drug delivery to the site of action.Because they are - Biologically inert in nature,- Devoid of any antigenic, pyrogenic or allergenic reactions- Do not cause unfavorable side effects as wellLiposomes were first described by British haematologist
 Dr. Alec D Bangham
in 1961(published 1964), at the Babraham institute, Cambridge.The name liposome is derived from two Greek words 'Lipid' meaning fat and 'Soma' meaningbody.
 Definitions
:
 
 Bangham et al 
.,1965
: Simple microscopic vesicles in which an aqueous volume isentirely enclosed by a membrane composed of lipid molecule.
 
Weiner N. et al 
.,1989 : A
s a microstructure consisting of one or more concentricspheres of lipid bilayer separated by water or aqueous buffer compartments.The drug molecules can encapsulated in aqueous space or intercalated into the lipid bilayer.The particle size of liposomes ranges from
20 nm to 10 μm
in diameter. Pharmaceuticalresearchers use the tools of 
biophysics
in evaluating liposomal dosage forms. Liposomeshave covered predominantly
medical,
albeit some non-medical areas like bioreactors,catalysts, cosmetics and ecology.

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