M.Pharm (Pharmaceutics) 2010-2011 Liposomes in Drug DeliveryMaliba Pharmacy College, Tarsadi Page 3
Number of carriers was utilized to carry drug at the target organ/tissue which includeimmunoglobulins, serum proteins, synthetic polymers, lipid vesicles (liposomes),microspheres, erythrocytes, reversed micelles, niosomes, pharmacosomes, etc.Among them, liposomes show strong potential for efficient drug delivery to the site of action.Because they are - Biologically inert in nature,- Devoid of any antigenic, pyrogenic or allergenic reactions- Do not cause unfavorable side effects as wellLiposomes were first described by British haematologist
Dr. Alec D Bangham
in 1961(published 1964), at the Babraham institute, Cambridge.The name liposome is derived from two Greek words 'Lipid' meaning fat and 'Soma' meaningbody.
Bangham et al
: Simple microscopic vesicles in which an aqueous volume isentirely enclosed by a membrane composed of lipid molecule.
Weiner N. et al
.,1989 : A
s a microstructure consisting of one or more concentricspheres of lipid bilayer separated by water or aqueous buffer compartments.The drug molecules can encapsulated in aqueous space or intercalated into the lipid bilayer.The particle size of liposomes ranges from
20 nm to 10 μm
in diameter. Pharmaceuticalresearchers use the tools of
in evaluating liposomal dosage forms. Liposomeshave covered predominantly
albeit some non-medical areas like bioreactors,catalysts, cosmetics and ecology.