Name of Drug Mefenamic Acid

Generic Name Mefenamic Acid

Specific Action Therapeutic Actions: Antiinflammatory, analgesic, and antipyretic activities r/t inhibitionof prostaglandin synthesis. Indications: Relief of moderate pain when therapy will not exceed 1 wk. Treatment of primary dysmenorrhea

Mechanism of Action Metabolism: T1/2: 2 4 hr Distribution: Crosses placenta, enters breast milk Excretion: Feces, Urine

Complications Contraindicated with hypersensitivity to mefenamic acid, aspirin allergy, and as treatment of perioperative pain with coronary bypass grafting. Use cautiously with asthma, renal or hepatic impairment, peptic ulcer disease, GI bleeding, hypertension, heart failure, pregnancy lactation.

Adverse Reactions CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, tinnitus, ophthalmic effects Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis GU: Dysuria, renal impairment Hematologic: Bleeding, Platelet inhibition with higher doses, neutropenia, eosinophilia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia Respiratory: Dyspnea, Hemoptysis,

Nursing Responsibilities Assessment: History: Allergies, renal, hepatic, CV, GI conditions; pregnancy; lactation. Physical: Skin color and lesions; orientation, reflexes, ophthalmologic and audiometric evaluation, peripheral sensation; P, edema; R, adventitious sounds; liver evaluation; CBC, clotting times, LFTs, renal function tests; serum electrolytes, stool guaiac.

pharyngitis, bronchospasm, rhinitis Other: Peripheral edema, anaphylactoid reactions to anaphylactic shock. Cephalexin Cephalexin Therapeutic Actions: Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death Indications: Respiratory tract infections caused by Streptococcus pneumonia, group A betahemolytic streptococci Skin and skin structure infections caused by staphylococcus, streptococcus Otitis media Metabolism: T1/2: 50-80 min Distribution: Crosses the placenta, enters breast milk Excretion: Urine Contraindicated with allergy to cephalosporins or penicillins Use cautiously with renal failure, lactation, pregnancy CNS: Headache, dizziness, lethargy, paresthesias GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembrano us colitis, hepatotoxicity GU: Nephrotoxicity Hematologic: Bone marrow depression Hypersensitivity: Ranging from rash to fever to anaphylaxis; serum sickness reaction Assessment: History: Penicillin or cephalosporin allergy, pregnancy, or lactation Physical: Renal function tests, respiratory status, skin status; culture and sensitivity tests of infected area

caused by S. pneumonia, Haemophilus influenza, streptococcus, staphylococcus, Moraxella catarrhalis Bone infections caused by staphylococcus, proteus mirabilis GU infections caused by Escherichia coli, P. mirabilis, Klebsiella Ferrous Sulfate Ferrous Sulfate Therapeutic Actions: Elevates the serum iron concentration, and is then converted to Hgb or trapped in the reticuloendothelial cells for storage and eventual conversion to a usable form of iron. Indications: Metabolism: Recycled for use; T1/2: Not known Distribution: Crosses placenta, Enters breast milk Excretion: Unknown Contraindicated w/ allergy to any ingredient; sulfite allergy; hemochromatosi s, hemosiderosis, hemolytic anemias. Use cautious with normal iron balance; peptic ulcer, regional enteritis, ulcerative colitis.

Other: superinfections

CNS: CNS toxicity, acidosis, coma and death with overdose GI: GI upset, anorexia, nausea, vomiting, constipation, diarrhea, dark stools, temporary staining of teeth (liquid preparations)

Assessment: History: Allergy to any ingredient, sulfite; hemochromatos is, hemosiderosis, hemolytic anemias; normal iron balance; peptic ulcer, regional enteritis, ulcerative colitis

 Prevention and treatment of iron deficiency anemias Dietary supplement for iron Unlabeled use: Supplemental use during epoetin therapy to ensure proper hematologic response to epoetin

Physical: Skin lesions, color; gums, teeth (color); bowel sounds; CBC, Hgb, Hct, serum ferritin and iron levels.