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Lysine: An effective adjunct treatment for Herpes Simplex Virus outbreaks

Lysine: An effective adjunct treatment for Herpes Simplex Virus outbreaks

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Published by HerpesSimplexVirus
L-Lysine : An effective adjunct treatment for Herpes Simplex Virus outbreaks

In humans, the herpes simplex virus (HSV) can cause the common cold sore, herpes simplex keratitis and genital herpes. L-lysine is simply an essential amino acid (i.e. not produced by the body) that is commonly found in foods, and all of us likely have some every day. It just so happens that the herpes viruses as a group have their replication inhibited in an environment where there is a larger concentration of l-lysine, compared to another amino acid "arginine" (which is produced by the body). Thus, we can take advantage of this situation by saturating the virus with lysine and thus suppressing the virus’ ability to replicate.
L-Lysine : An effective adjunct treatment for Herpes Simplex Virus outbreaks

In humans, the herpes simplex virus (HSV) can cause the common cold sore, herpes simplex keratitis and genital herpes. L-lysine is simply an essential amino acid (i.e. not produced by the body) that is commonly found in foods, and all of us likely have some every day. It just so happens that the herpes viruses as a group have their replication inhibited in an environment where there is a larger concentration of l-lysine, compared to another amino acid "arginine" (which is produced by the body). Thus, we can take advantage of this situation by saturating the virus with lysine and thus suppressing the virus’ ability to replicate.

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Published by: HerpesSimplexVirus on Oct 17, 2012
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L-Lysine : An effective adjunct treatment for Herpes Simplex Virus outbreaks
 In humans, the herpes simplex virus (HSV) can cause the common cold sore, herpessimplex keratitis and genital herpes.
How does L-Lysine work?
 L-lysine is simply an essential amino acid (i.e. not produced by the body) that is commonlyfound in foods, and all of us likely have some every day. It just so happens that the herpesviruses as a group have their replication inhibited in an environment where there is a larger concentration of l-lysine, compared to another amino acid "arginine" (which is produced bythe body)[1]. Thus, we can take advantage of this situation by saturating the virus with lysine
and thus suppressing the virus’ ability to replicate. Lysine is readily availa
ble in most healthfood stores (e.g. Holland and Barrett) and many chemists, as a tablet or capsule. It is alsorelatively cheap (e.g. 120x1000mg tablets £7).
Recommended as an adjunct treatment
 If you have a patient who suffers from recurrent HSK, recommend L-Lysine at the dosagebelow, at first symptoms of outbreak, and to seek medical advice as per normal. This shouldhelp reduce the severity and duration of the outbreak.(Personally, I also recommend it when they have an ordinary cold/flu, to reduce the chancesof an outbreak developing.)
Dosage:
1000mg x2 (1 tbl in morning and 1 tbl in evening, with water), each day for durationof outbreak or until symptoms stop. No longer than 7 days would generally be required.The above 2000mg l-lysine dosage is well within maximum recommended therapeuticdosage levels according to the FDA (100mg/kg/day, e.g. 3 times below for a 60kg person). Asupplement dose of 3000mg per day has been found to be safe for short-term use[2].I have a handful of recurrent HSV keratitis sufferers and I have been advising thissupplement with good results. It is important to limit such outbreaks as each recurrent attackinduces greater damage to the corneal nerves leading to reduced corneal sensitivity, cornealscarring and possible complications can include uveitis.From emedicinehealth.com
"There are about 500,000 people in the U.S. with a history of herpes simplex eye disease.Approximately 20,000 new cases of ocular herpes occur in the U.S. annually, and more than 28,000 reactivations occur in the U.S. annually. It usually affects only one eye and is one of the most frequent causes of blindness in one eye in the U.S." 
 
This can be a sight-threatening condition, thus if we know of a potentially effectiveand safe adjunct treatment option - why not try it?
 In the journal evidence below, please note that it is only the low dosage studies that wereineffective. Listed in chronological order:
 
A multicentered study of lysine therapy in Herpes simplex infection.
 
 
Griffith RS, Norins AL, Kagan C. - Dermatologica. 1978;156(5):257-67.312-1200mg (single or multiple doses) beneficial effect in accelerating recovery 
Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlledcrossover study
.Milman N, Scheibel J, Jessen O. - Acta Derm Venereol. 1980;60(1):85-71000mg longer recurrence-free rate
Subjective response to lysine in the therapy of herpes simplex
 
David E. Walsh*, Richard S. Griffith† and Ali Behforooz
- Oxford Journals Medicine Journalof Antimicrobial Chemotherapy Volume 12, Issue 5, p. 489-496 (1983)936mg 88% considered supplemental lysine effective
Failure of lysine in frequency in frequently recurrent HS infection. Treatment andprophylaxis
  Arch Dermatol. 1984 Jan;120(1):48-51. - DiGiovanna JJ, Blank H.400mg tds = total 1200mg = fail(note the low dose separated throughout the day)
Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride
.McCune MA, Perry HO, Muller SA, O'Fallon WM. - Cutis. 1984 Oct;34(4):366-731248mg effective at decreasing recurrence rate,624mg not effective
 
Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis.
 Thein DJ, Hurt WC. - Oral Surg Oral Med Oral Pathol. 1984 Dec;58(6):659-66.1000mg useful in reducing recurrence rate
Success of L-lysine therapy in frequently recurrent herpes simplex infection.Treatment and prophylaxis.
 Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A. - Dermatologica.1987;175(4):183-90.1000mg tds = total 3000mg = success in all areas: lower recurrence, significantly reducedsymptoms and healing time 
Clinical effectiveness of lysine in treating recurrent aphthous ulcers and herpeslabialis.
 Wright EF. - Gen Dent. 1994 Jan-Feb;42(1):40-2; quiz 51-2.Helps reduce recurrence rate 
Lysine for management of herpes labialis.
 Tomblin FA Jr, Lucas KH - Am J Health Syst Pharm. 2001;58(4):298-300, 304.Tomblin and Lucas report in detail on the results of half a dozen studies of varying size,design and duration. According to Tomblin and Lucas, the studies showed lysine tended tobemore effective as a preventative for HSV than as a treatment for an outbreak, and thatresults were
dose-dependent
.They noted that most of the more rigorous studies --- double-blind, placebo controlled and providing statistical analysis --- were small, and suggestedlarger, well-designed studies could provide a more definitive answer.[2]
Will taking the amino acid supplement lysine prevent or treat the herpes simplex

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