Read without ads and support Scribd by becoming a Scribd Premium Reader.

Language:

Go BackAdd Note

Link

Embed

Save for later

2007

Guide to

Biotechnology

The

Guide to Biotechnology

is compiled by the Biotechnology IndustryOrganization (BIO)Debbie Strickland, BIO, Director of Marketing, Editor

Contributors

Deb Carstoiu, BIO, Director of State Media Relations and AdvocacyElinor Van Dyck, Blue House Publishing, Art DirectorBarbara Glenn, BIO, Managing Director of Animal BitoechnologyCrispin Littlehales, Writer/EditorAdrienne Massey, Ph.D., Writer/Editor

Guide to Biotechnology

Biotechnology Industry Organization

Contents

Biotechnology: A Collectionof Technologies 1

What Is Biotechnology? ......................................................1Cells and Biological Molecules ...........................................1

Biotechnology Industry Facts 2

Market Capitalization, 1994–2005 .....................................3U.S. Industry Statistics: 1994–2005 ...................................3New Biotech Drug and Vaccine Approvals/ New Indication Approvals by Year.................................4North American Biotech Companiesby State and Province ....................................................4Total Financing, 1998–2005 ...............................................5Biotech Industry Financing, 2005 .....................................5

Time Line 6

Biotechnology Policy Milestones .....................................16

The Technologiesand Their Applications 18

Bioprocessing Technology ................................................18Monoclonal Antibodies .....................................................18Cell Culture ......................................................................19Recombinant DNA Technology ........................................21Cloning .............................................................................21Protein Engineering ........................................................22Biosensors ........................................................................22Nanobiotechnology...........................................................23Microarrays .......................................................................23

Biotechnology Tools in Researchand Deelopment 25

Research Applications ......................................................25

Includes stem cell technology, cloning, microarraytechnology, antisense and RNA intererence, and gene knockouts

Putting the Pieces Together: ‘Omics’ ...............................29

Genomics, proteomics and bioinormatics

Product Development Applications .................................31

Health-Care Applications 34

Diagnostics .......................................................................34Therapeutics .....................................................................34Personalized Medicine ......................................................37Regenerative Medicine .....................................................39 Vaccines ............................................................................39Plant-Made Pharmaceuticals ............................................41

Therapeutic Deelopement Oeriew 42

Biotech Drug Development Process ................................44

Approed Biotechnology Drugs 45Agricultural Production Applications 65

Crop Biotechnology ..........................................................65

Includes production improvement, impact on develop-ing countries, environmental and economic benets, and regulations

Forest Biotechnology .......................................................69 Animal Biotechnology ......................................................70

Includes companion animals, applications or human medicine, and environmental and conservation eorts

Aquaculture ......................................................................76Global Area o Transgenic Crops,1995 to 2005: Industrial and Developing Countries ..78Global Area o Transgenic Crops in 2004 and 2005by Country ..................................................................78Global Area o Transgenic Crops in 2004 and2005 by Crop ...............................................................79Global Area o Transgenic Crops, 1996 to 2005,by Crop ........................................................................79Global Area o Transgenic Crops in 2004 and2005 by Trait ...............................................................80