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MG

MG

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Published by petradido
Neuro
Neuro

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Published by: petradido on Mar 19, 2013
Copyright:Attribution Non-commercial

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12/17/2013

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 A Aneuromuscularisneuromuscularisjunctio junctio(NMJ):(NMJ):
NMJ mediatora azacetilcholin (ACh)
NMJ:
 presinapticus
ingerület
→→→
 postsinapticus
akcióspotenciál
→→→
izomcontractio
3 része:
presinapticus membran
:
ACh szintézis, tárolás (sinaptikus vesiculumok), felszabadítás(exocitosis, Ca++dependens)
ACh-hidrolizis végtermékeinek újrafelvétele
sinapticus rés
:
200
Ă
, acetilcholinesterase (AChE) aktivitás
postsinaptikus membran
:
Red
ı
z
ı
tt, 10X hosszabb mint a presinapt.membr.
Acetilcholin receptorok (AChR) a red
ı
k csúcsán:
15.000/ 
µ
m2
Centralis ion-csatorna: megnyílik az ACh-molekula köt
ı
désének illanatában
 
A normálisneuromuscularis junctio szerkezete
Oh
     O      h

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