DRUG ACTING on motor system

Click to edit Master subtitle style Zunilda Dj. Sadikin Substracted from Lllmann H, Ziegler A., Mohr K, Bieger D (eds), Color Atlas of Pharmacology, 2nd ed., Thieme Stuttgart New York 2000

3/26/13

Direct and indirect parasympathomimetics

3/26/13

Direct and indirect parasympathomimetics

3/26/13

Mechanisms for influencing skeletal muscle tone

3/26/13

Inhibition of neuromuscular transmission and electromechanical coupling

3/26/13

Class of drugs
Indirect parasympathomimetic (anticholinesterase): physostigmine, neostigmine, pyridostigmine Convulsant toxins: tetanus toxin, strychnine, botulinum toxin Centrally acting muscle relaxants: dantrolene Nondepolarizing muscle relaxants: dtubocurarine, pancuranium, vecuranium, alcuranium 3/26/13 Depolarizing muscle relaxants:

Non-depolarizing muscle relaxants

3/26/13

Action of depolarizing m.relaxants

succinylcholine acts as agonist at endplate nicotinic cholinoceptors 3/26/13

Unlike ACh, succinylcholine is not hydrolyzed by3/26/13

The AP is due to opening of voltagegated Na-channel proteins, allowing Na+ ions to flow through the sarcolemma and to cause depolarization. After a few milliseconds, the Na channels close automatically (inactivation), the membrane potential returns to resting levels, and the AP is terminated. When membrane potential remains incompletely 3/26/13 renewed opening of Na channels, hence a new AP, is repolarized,

Antiepileptics

3/26/13

Indications for antiepileptics

3/26/13

Neuronal sites of action of antiepileptics

3/26/13

Sites of action of antiepileptics in GABAergic synapse

3/26/13