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Published by dlneisha61

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Published by: dlneisha61 on Mar 18, 2009
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05/10/2014

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ReceptorSubtype
Alpha
1
Alpha
2
Beta
1
Beta
2
Dopamine
Location
EyeArterioles (skin, viscera, mucousmembranes)VeinsSex organs, maleBladder neck and prostatic capsulePresynaptic nerve terminalsHeartKidneyArterioles (heart, lung, andskeletal mucle)BronchiUterusLiverSkeletal muscleKidney
Response to Receptor Activation
Mydriasis—
wide eyed with fear 
ConstrictionConstrictionEjaculationContractionInhibition of transmitter release—
decreasessympathetic nervous system (SNS) out- flow to the blood vessels and heart 
Increased rate, force of contraction, and AVconduction velocityRenin release—
 RAS
DilationDilationRelaxationGlycogenolysisEnhanced contraction, glycogenolysisDilation of kidney vasculature
Drug Receptor Types
Functions of Peripheral Adrenergic Receptor Subtypes
ReceptorSubtype
Nicotinic
n
Nicotinic
m
Muscarinic
Location
All autonomic nervous systemganglia and the adrenal medullaNeuromuscular junctionAll parasympathetic target organs:EyeHeartLungBladderGI tractSweat glandsSex organsBlood vessels
Response to Receptor Activation
Stimulation of parasympathetic andsympathetic postganglionic nerves andrelease of epinephrine from the adrenalmedullaContraction of skeletal muscleMiosisDecreased rateConstriction of bronchiPromotion of secretionsVoidingSalivationIncreases gastric secretions, intestinaltone, and motilityDefecationGeneralized sweatingErectionVasodilation
Functions of Peripheral Cholinergic Receptor Subtypes
Drug Endings
Drug Endings
-zosin-olol, -lol -zepam, -zolam-pril -artan-dipine-statin-ase, -plase-parin-sone-dronate
Drug Classification
Alpha-adrenergic blockerBeta-adrenergic blockerBenzodiazepine (BZD)Angiotensin-converting enzyme (ACE) inhibitorAngiotensin-receptor blocker (ARB)Calcium channel blockerLipid-lowering drugThrombolyticAnticoagulantCorticosteroidBisphosphonate for osteoporosis
Drug Example
 pra
 zosin
metopr 
 olol 
dia
 zepam
 , alpra
 zolam
lisino
 pril 
candes
 artan
amlo
 dipine
atorva
 statin
alte
 plase
enoxa
 parin
 predni
 sone
alen
 dronate
Drug Endings—cont’d
Drug Endings
-terol -tidine-prazole-cillin-cef, -ceph-cycline-floxacin-thromycin-micin, -mycin-azole
Drug Classification
BronchodilatorHistamine
2
blocker–acid reducerProtein pump inhibitor–acid reducerPenicillin antibioticCephalosporin antibioticTetracycline antibioticFluoroquinolone antibioticMacrolide antibioticAminoglycoside antibioticAntifungal
Drug Example
albu
 terol 
cime
 tidine
ome
 prazole
amoxi
 cillin cef 
azolintetra
 cycline
levo
 floxacin
azi
 thromycin
genta
 mycin
itracon
 azole
Continued 
Copyright ©2007 by Saunders, an imprint of Elsevier Inc.
 
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Copyright ©2007 by Saunders, an imprint of Elsevier Inc.Copyright ©2007 by Saunders, an imprint of Elsevier Inc.
BETHANECHOL (URECHOLINE)Muscarinic Agonist
Activates muscarinic receptorsCauses contraction of the detrusor muscle of the bladder
Uses
Postoperative urinary retention
Adverse Effects
HypotensionBradycardia, dysrhythmiasBronchoconstrictionGI effects
BETHANECHOL (URECHOLINE)Muscarinic AgonistATROPINEMuscarinic Antagonist (Anticholinergic)
Blocks muscarinic receptorsIncreases heart rateDecreases salivary, bronchial, sweat, and acid-secreting cell secretionsRelaxes bronchial smooth musclesDecreases bladder tone and GI motilityDilates pupils (mydriasis)
Uses
Preanesthesia to prevent bradycardia, treatment of bradycardiaDilation of pupil for ocular examination or surgeryIntestinal hypertonicity and hypermotilityAntidote for muscarinic-agonist poisoning
Adverse Effects
Blurry vision, urinary retention, dry mouth, constipation, tachycardiaIncreases intraocular pressure
ATROPINEMuscarinic Antagonist (Anticholinergic)
 
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Copyright ©2007 by Saunders, an imprint of Elsevier Inc.Copyright ©2007 by Saunders, an imprint of Elsevier Inc.
NEOSTIGMINE (PROSTIGMINE)Reversible Cholinesterase Inhibitor
Prevents the degradation of acetylcholine (ACh)Enhances the effect of ACh to stimulate skeletal muscle
Uses
Myasthenia gravisReversal of neuromuscular blockade in postoperative patients
Adverse Effects
Excessive glandular secretions, increased GI motilityUrinary urgency, bradycardia, sweating, and miosisCholinergic crisis—treat with atropine
NEOSTIGMINE (PROSTIGMINE)Reversible Cholinesterase InhibitorSUCCINYLCHOLINEDepolarizing Neuromuscular Blocker
Causes paralysis of muscle by preventing repolarization
Uses
Muscle relaxation during endotracheal intubationUsed for short operative procedures
Adverse Effects
Prolonged paralysis in genetically determined individualsMalignant hyperthermia—treat with dantroleneMuscle pain, hyperkalemia
SUCCINYLCHOLINEDepolarizing Neuromuscular Blocker

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