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Polycythemia: Types
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Pathophysiology
•Dizziness
•Headache
•Thrombosis
•Hypertention (20-50%)
Blood Picture:
RBCs usually () 7-10x106
HB 17-22 gm%
Ht usually () 60-70%
Platelets usually ↑, may reach (million or more)
WBCs ↑ in the majority of cases
Polycythemia Vera: Diagnosis
• Myelosclerosis
• Myeloid leukemia
• Vascular thrombosis
• Haemorrhage
• 2ry gout
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Polycythemia Vera:Treatment
• Repeated Venesection:
→ Iron defeciency
Polycythemia Vera:Treatment
2. Radioactive phosphorus:
Long remissions
3. Chemotherapy
Busulphan (Myleran)
Chlorumbucil (leukeran)
Hydroxyurea (Hydrea)
Secondary polycythemia
Physiological:
New born
High altitude
Pathological
Obstructive lung disease
congenital cyanotic heart disease
Renal tumors
cushing syndrome
Normal WBCs - Platelets- no splenomegally
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